全文获取类型
收费全文 | 2338987篇 |
免费 | 183590篇 |
国内免费 | 7304篇 |
专业分类
耳鼻咽喉 | 30240篇 |
儿科学 | 76302篇 |
妇产科学 | 64593篇 |
基础医学 | 333946篇 |
口腔科学 | 64983篇 |
临床医学 | 215799篇 |
内科学 | 466836篇 |
皮肤病学 | 53702篇 |
神经病学 | 190972篇 |
特种医学 | 91276篇 |
外国民族医学 | 522篇 |
外科学 | 348785篇 |
综合类 | 52619篇 |
现状与发展 | 5篇 |
一般理论 | 930篇 |
预防医学 | 192302篇 |
眼科学 | 51477篇 |
药学 | 167751篇 |
9篇 | |
中国医学 | 3916篇 |
肿瘤学 | 122916篇 |
出版年
2018年 | 24021篇 |
2016年 | 21667篇 |
2015年 | 24478篇 |
2014年 | 34090篇 |
2013年 | 51780篇 |
2012年 | 66271篇 |
2011年 | 71142篇 |
2010年 | 43012篇 |
2009年 | 41714篇 |
2008年 | 67005篇 |
2007年 | 71612篇 |
2006年 | 72156篇 |
2005年 | 70243篇 |
2004年 | 67209篇 |
2003年 | 64994篇 |
2002年 | 62454篇 |
2001年 | 106406篇 |
2000年 | 109031篇 |
1999年 | 91701篇 |
1998年 | 27252篇 |
1997年 | 24561篇 |
1996年 | 25563篇 |
1995年 | 25152篇 |
1994年 | 23393篇 |
1993年 | 21992篇 |
1992年 | 75226篇 |
1991年 | 73586篇 |
1990年 | 71190篇 |
1989年 | 68253篇 |
1988年 | 63317篇 |
1987年 | 62291篇 |
1986年 | 58918篇 |
1985年 | 56572篇 |
1984年 | 43061篇 |
1983年 | 36992篇 |
1982年 | 22746篇 |
1981年 | 20570篇 |
1980年 | 19374篇 |
1979年 | 40061篇 |
1978年 | 29269篇 |
1977年 | 24652篇 |
1976年 | 22667篇 |
1975年 | 24151篇 |
1974年 | 28900篇 |
1973年 | 28053篇 |
1972年 | 26154篇 |
1971年 | 24301篇 |
1970年 | 22570篇 |
1969年 | 21249篇 |
1968年 | 19856篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
51.
52.
D Monnier† C Vidal‡ L Martin§ A Danzon¶ F Pelletier† E Puzenat† MP Algros†† D Blanc† R Laurent† PH Humbert† F Aubin† 《Journal of the European Academy of Dermatology and Venereology》2006,20(10):1237-1242
BACKGROUND: Dermatofibrosarcoma protuberans (DFSP) is a rare malignant tumour of the skin, with an estimated incidence of 0.8 to five cases per 1 million people per year. OBJECTIVE: To study epidemiological, immunohistochemical and clinical features, delay in diagnosis, type of treatment and outcome of DFSP from 1982 to 2002. METHODS: Using data from the population-based cancer registry, 66 patients with pathologically proved DFSP were included (fibrosarcomatous DFSP were excluded). Each patient lived in one of the four departments of Franche-Comté (overall population of 1 million people) at the time of diagnosis. The main data sources came from public and private pathology laboratories and medical records. The rules of the International Agency for Research on Cancer were applied. RESULTS: The estimated incidence of DFSP in Franche-Comté was about three new cases per 1 million people per year. Male patients were affected 1.2 times as often as female patients were. The trunk (45%) followed by the proximal extremities (38%) were the most frequent locations. DFSP occurred mainly in young adults between 20 and 39 years of age. Mean age at diagnosis was 43 years, and the mean delay in diagnosis was 10.08 years. Our 66 patients initially underwent a radical local excision. Among them, 27% experienced one or more local recurrences during 9.6 years of follow-up. There was one regional lymph node recurrence without visceral metastases. These recurrences were significantly related to the initial peripheral resection margins. We observed a local recurrence rate of 47% for margins less than 3 cm, vs. only 7% for margins ranging from 3 to 5 cm [P=0.004; OR=0.229 (95%, CI=0.103-0.510)]. The mean time to a first local recurrence was 2.65 years. Nevertheless, there was no death due to the DFSP course at the end of the follow-up, and the final outcome was favourable. CONCLUSION: Our study emphasizes the importance of wide local excision with margins of at least 3 cm in order to prevent local recurrence. However, the recent development of inhibitors of signal transduction by the PDGFB pathway should soon modify the surgical strategy, which is often too mutilating. 相似文献
53.
Parupudi V J Sriram Guduru V Rao Nageshwar D Reddy 《Indian journal of gastroenterology》2006,25(1):39-41
Endoscopic clips have been used mainly for control of gastrointestinal (GI) bleeding and occasionally for closure of GI perforations. However, closure of spontaneous esophageal perforation (Boerhaave's syndrome) by clipping has not been reported. We described successful non-surgical closure of spontaneous esophageal perforation by endoscopic clipping in a patient with bilateral pyopneumothorax and septicemia. 相似文献
54.
55.
56.
57.
S Balzer D T Schneider M B Bernbeck M J?ger O Mils J Schaper R Willers R Krauspe U G?bel R Wessalowski 《International journal of hyperthermia》2006,22(6):451-461
PURPOSE: In children with locally advanced or recurrent malignant tumours, prognosis can be improved by regional deep hyperthermia (RHT) in combination with platin-based chemotherapy. However, because of the increasing number of patients that achieve long-time remission with this therapy, it is necessary to evaluate long-term sequelae of thermochemotherapy. During the years 1993-2004 one has observed avascular osteonecrosis (AON) of the femoral head after RHT in seven children with pelvic germ cell tumours or rhabdomyosarcomas. METHODS: Although AON may develop in patients with malignancies treated with chemo- or radiotherapy alone, RHT might nevertheless contribute to the occurrence of AON. In order to determine potential risk factors for AON after RHT, this study analysed the relationship of AON to the patient's age, medical history and treatment parameters such as thermal dose equivalent and power output. RESULTS AND CONCLUSIONS: In the present study AON was associated with young age as well as intensity of hyperthermia indicated by high power levels that exceed 20 W per kg body weight and/or application of eight or more heat sessions as well as additional radiotherapy. Based on this observation, it was assumed that an optimized three dimensional thermal field modelling may be helpful to avoid hazardous temperatures in the femoral heads during RHT treatment and to reduce AON of the femoral heads. 相似文献
58.
59.
JM Martín† L Calduch† C Monteagudo‡ I Molina† D Ramón† V Alonso† E Jordᆠ《Journal of the European Academy of Dermatology and Venereology》2006,20(4):428-431
Cutaneous plasmacytosis is a rare disorder characterized by a benign proliferation of mature plasma cells that appears as multiple dark-brown to purplish skin lesions, often associated with polyclonal hypergammaglobulinaemia. We present the case of a 55-year-old Caucasian man who suffered from a cutaneous plasmacytosis associated with two different carcinomas. Cutaneous plasmacytosis seems to be a reactive process because most cases reported are not associated with any apparent underlying disease. Nevertheless, because few reported cases were associated with malignancies, screening of additional neoplasms would be justified. 相似文献
60.
S F Wong A Lee-Tannock D Amaraddio F Y Chan H D McIntyre 《Ultrasound in obstetrics & gynecology》2006,28(7):934-938
OBJECTIVE: To assess the effect of glucose control on the rate of growth of fetuses in women with pregestational diabetes mellitus (Types 1 and 2). METHODS: All pregestational diabetic women booked at Mater Mothers' Hospital, Brisbane, Australia, between 1 January 1994 and 31 December 2002, were included. Pregnancies with congenital fetal anomalies, multiple pregnancies, and pregnancies terminated prior to 20 weeks' gestation were excluded. Dating scans were performed before 14 weeks' gestation and serial scans were performed at 18, 24, 28, 32 and 36 weeks. Fetal parameters, including biparietal diameter, femur length and abdominal circumference, were recorded. The daily growth rates for biparietal diameter, femur length, and fetal abdominal area were calculated and compared with those in a low-risk (non-diabetic) population. The growth rates in fetuses of women with satisfactory diabetic control (HbA1c < 6.5%) and unsatisfactory control (HbA1c > or = 6.5%) in the three trimesters were compared. RESULTS: A total of 174 diabetic pregnancies were included and a total of 997 ultrasound scans were performed. The growth rates for fetuses of mothers with diabetes mellitus were significantly higher than for those in the low-risk population. The z-scores for biparietal diameter, femur length, and fetal abdominal area were 0.18, 0.59 and 1.44, respectively. Fetuses of diabetic mothers with high HbA1c in the first trimester had significantly greater fetal abdominal area growth rate than those with normal HbA1c (fetal abdominal area z-score of 1.7 vs. 0.75, P = 0.009). Although the fetal abdominal area z-scores in fetuses of diabetic mothers with high HbA1c in the second or third trimesters were also higher than those with normal HbA1c levels, the differences did not reach statistical significance. Maternal obesity did not influence the fetal growth rate. CONCLUSION: The rate of growth of fetuses of diabetic mothers differs from that of the normal population. Growth acceleration persists until the late third trimester. Moreover, periconceptional glucose control appears to have a significant effect on accelerated growth of the fetal abdominal area. 相似文献