全文获取类型
收费全文 | 16460篇 |
免费 | 1038篇 |
国内免费 | 44篇 |
专业分类
耳鼻咽喉 | 229篇 |
儿科学 | 353篇 |
妇产科学 | 393篇 |
基础医学 | 2119篇 |
口腔科学 | 1088篇 |
临床医学 | 1235篇 |
内科学 | 3584篇 |
皮肤病学 | 362篇 |
神经病学 | 1304篇 |
特种医学 | 415篇 |
外国民族医学 | 1篇 |
外科学 | 1903篇 |
综合类 | 113篇 |
一般理论 | 6篇 |
预防医学 | 1652篇 |
眼科学 | 275篇 |
药学 | 1493篇 |
中国医学 | 119篇 |
肿瘤学 | 898篇 |
出版年
2023年 | 108篇 |
2022年 | 306篇 |
2021年 | 530篇 |
2020年 | 331篇 |
2019年 | 433篇 |
2018年 | 547篇 |
2017年 | 400篇 |
2016年 | 429篇 |
2015年 | 506篇 |
2014年 | 618篇 |
2013年 | 847篇 |
2012年 | 1105篇 |
2011年 | 1169篇 |
2010年 | 664篇 |
2009年 | 579篇 |
2008年 | 901篇 |
2007年 | 879篇 |
2006年 | 792篇 |
2005年 | 731篇 |
2004年 | 620篇 |
2003年 | 576篇 |
2002年 | 500篇 |
2001年 | 421篇 |
2000年 | 391篇 |
1999年 | 314篇 |
1998年 | 136篇 |
1997年 | 117篇 |
1996年 | 103篇 |
1995年 | 89篇 |
1994年 | 77篇 |
1993年 | 76篇 |
1992年 | 216篇 |
1991年 | 189篇 |
1990年 | 187篇 |
1989年 | 163篇 |
1988年 | 145篇 |
1987年 | 105篇 |
1986年 | 130篇 |
1985年 | 109篇 |
1984年 | 84篇 |
1983年 | 71篇 |
1982年 | 63篇 |
1981年 | 54篇 |
1980年 | 51篇 |
1979年 | 97篇 |
1978年 | 51篇 |
1977年 | 56篇 |
1976年 | 46篇 |
1975年 | 55篇 |
1974年 | 48篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
11.
12.
13.
Salvatore Sembronio Alberto Maria Albiero Massimo Robiony Fabio Costa Corrado Toro Massimo Politi 《Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics》2007,103(2):e1-e6
Septic arthritis of the temporomandibular joint (TMJ) is infrequently reported. We present a case of septic arthritis of the TMJ following the extraction of the left upper second molar that occurred 1 week before beginning of symptoms. No evident predisposing factors were detected. Arthroscopic diagnosis of septic arthritis, lysis and lavage, and capsular stretch were performed. Cultures taken from the TMJ space grew Streptococcus sp. After 1 month of antimicrobial therapy the patient was asymptomatic and mandibular function was normal. Literature related to septic arthritis of TMJ and its treatment was reviewed. Different surgical procedures are available to treat this condition. Arthroscopy should be preferred as initial treatment on account of the possibility of drainage and accurate lavage under direct visualization of joint space, at the same time allowing confirmation of diagnostic hypotheses. Improving joint mobility with lysis of adhesions and capsular stretch in an early stage of disease may be helpful in stopping the fibrosis process. 相似文献
14.
Nancy Costa 《Journal of infusion nursing》2004,27(5):302-312
More than 10 million radiologic examinations requiring intravascular injection of iodinated contrast media are performed in the United States each year. Iodinated contrast media are considered to be safe diagnostic drugs, and the incidence of adverse reaction is low. However, as with any drug, the administration of contrast media is not without risk. Nurses involved in patient care should have some understanding of the properties and potential effects of iodinated contrast media. 相似文献
15.
Dario Roccatello Marco Formica Guido Cavalli Maria C. Amprimo Maria G. Pignatelli Paolo Costa Ruggero de Paulis Giacomo Quattrocchio rea Molino Gianbeppe Giordano 《Artificial organs》1990,14(1):69-72
Neutrophil oxidative metabolism, C3d and beta 2 microglobulin levels, were assessed in nine consecutive patients undergoing cardiopulmonary bypass surgery with polypropylene hollow fiber oxygenators for open cardiac operations. Generation of oxygen free radicals by neutrophils was measured as luminol-enhanced chemiluminescence after stimulation with opsonized Zymosan and phorbol myristate acetate. A significant increase in light emission was detected by using both of the chemiluminescence stimulators. Moreover, a remarkable and significant increase in C3d levels was found already at 10 min. Conversely minimal changes in levels of beta 2 microglobulin were detected during cardiopulmonary bypass surgery. These data suggest that the impact of the patient blood with the foreign surface of cardiopulmonary bypass results in activation of phagocyte cells with increased potential in oxygen consumption. These effects could be partially complement-mediated. 相似文献
16.
C de Costa 《The Medical journal of Australia》1988,149(9):457-460
A sample of 400 Lebanese-born women who gave birth at Auburn District Hospital in 1987-1988 was compared with a sample of 400 Australian-born women who gave birth in the same time period. The Lebanese-born women were found to be older and of higher parity than were their Australian-born counterparts; and to have booked their hospital admission significantly later in pregnancy than did the Australian-born women. Lebanese-born women also had frequently made a consanguineous marriage. Certain antenatal and intrapartum complications were more common in the Lebanese-born women, and perinatal mortality and morbidity rates were higher among their infants. The particular problems of pregnancy in Lebanese-born women, and possible ways of overcoming these, are discussed. 相似文献
17.
Diazepam binding inhibitor (DBI) is a neuropeptide of 11 kDa molecular size and is unevenly distributed in human and rat brain. It appears to function as a negative allosteric modulator of GABAA receptors. In the present paper, using antibodies directed against several synthetic peptides, which correspond to selective regions of human DBI (DBI 51-70, DBI 37-50, DBI 81-101), it is shown that DBI is processed into at least 6 peptide fragments in both postmortem human brain and in cerebrospinal fluid (CSF). One of these fragments was identified as the synthetic DBI 51-70 fragment (an eikosaneuropeptide, ENP) by combined chromatographic procedures. Immunoblotting analysis of the other fragments, by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (PAGE), revealed an apparent molecular size, ranging from 3-4 kDa for four of them and a larger molecular form of 8 kDa. On the basis of the immunological properties, a tentative amino acid sequence was deduced. 相似文献
18.
Daniel B. Costa Christopher A. Fisher Kenneth B. Miller German A. Pihan David P. Steensma Richard J. Gibbons Douglas R. Higgs 《European journal of haematology》2006,76(5):432-435
Abstract: We describe a patient with acquired alpha-thalassemia myelodysplastic syndrome (ATMDS). A previously healthy 66-year-old man presented with hemoglobin of 9.3 g/dL, mean corpuscular volume 59 fL, and a bone marrow aspirate with increased erythroid precursors and hypolobulated megakaryocytes. Hemoglobin H inclusions were seen in most red cells after 1% brilliant cresyl blue supravital stain of the peripheral blood. At the molecular level, we identified of a novel mutation in the most 3' exon of the ATRX gene ( C GA→ T GA substitution in codon 2407) resulting in a premature termination codon (p.R2407X). This case provides further evidence for a link between ATRX mutations and ATMDS, and suggests a possible role for the conserved Q-box element in ATRX function. 相似文献
19.
L Bonina M Carbone P Mastroeni G B Costa P Mastroeni 《Journal of chemotherapy (Florence, Italy)》1992,4(6):353-357
This study was undertaken to investigate the efficacy of rufloxacin, a new quinolone which is interesting due to its pharmacokinetics characterized by a long plasma half-life, in the treatment of systemic salmonella infections in the mouse typhoid model. Innately susceptible BALB/c and resistant CBA mice were used to investigate the efficacy of rufloxacin in controlling systemic salmonella infections when given for brief or prolonged periods. The present study shows that rufloxacin is not only very effective on both mouse strains, but can completely eradicate the salmonellae from livers and spleens when given early in the infection of CBA resistant mice. 相似文献
20.
Geraldo F. Busatto Lyn S. Pilowsky Durval C. Costa John Mertehs Dirk Terriere Peter J. Ell Rachel Mulligan Michael J. Travis Josée E. Leysen Dominic Lui Sveto Gacinovic Wendy Waddington Anne Lingford-Hughes Robert W. Kerwin 《European journal of nuclear medicine and molecular imaging》1997,24(2):119-124
The mapping of 5-HT2 receptors in the brain using functional imaging techniques has been limited by a relative lack of selective radioligands.
Iodine-123 labelled 4-amino-N-[1-[3-(4-fluorophenoxy)propyl]-4-methyl-4-piperidinyl]-5-iodo-2-methoxybenzamide (123I-5-I-R91150 or123I-R93274) is a new ligand for single-photon emission tomography (SPET), with high affinity and selectivity for 5-HT2A receptors. This study reports on preliminary123I-5-I-R91150 SPET, wholebody and blood distribution findings in five healthy human volunteers. Maximal brain uptake was approximately
2% of total body counts at 180 min post injection (p.i.). Dynamic SPET sequences were acquired with the brain-dedicated, single-slice
multi-detector system SEM-810 over 200 min p.i. Early peak uptake (at 5 min p.i.) was seen in the cerebellum, a region free
from 5HT2A receptors. In contrast, radioligand binding in the frontal cortex increased steadily over time, up to a peak at approximately
100–120 min p.i. Frontal cortex-cerebellum activity ratios reached values of 1.4, and remained stable from approximately 100
min p.i. onwards. Multi-slice SPET sequences showed a pattern of regional variation of binding compatible with the autoradiographic
data on the distribution of 5-HT2A receptors in (cerebral cortex>striatum>cerebellum). These findings suggest that123I-5-I-R91150 may be used for the imaging of 5-HT2A receptors in the living human brain with SPET. 相似文献