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41.
Gil Miguel A. Varón Consuelo Cardona Genis Buil José A. 《International ophthalmology》2020,40(2):393-401
International Ophthalmology - The purpose of this prospective, randomized, double-masked, study was to compare the visual performance of patients after bilateral implantation of six different IOLs.... 相似文献
42.
Raffaella Greco MD Attilio Bondanza MD PhD Luca Vago MD PhD Lucia Moiola MD Paolo Rossi MD Roberto Furlan MD PhD Gianvito Martino MD Marta Radaelli MD Vittorio Martinelli MD Maria Rosaria Carbone MSc Maria Teresa Lupo Stanghellini MD Andrea Assanelli MD Massimo Bernardi MD Consuelo Corti MD Jacopo Peccatori MD Chiara Bonini MD Paolo Vezzulli MD Andrea Falini MD PhD Fabio Ciceri MD Giancarlo Comi MD 《Annals of neurology》2014,75(3):447-453
Neuromyelitis optica is a rare neurological autoimmune disorder characterized by a poor prognosis. Immunosuppression can halt disease progression, but some patients are refractory to multiple treatments, experiencing frequent relapses with accumulating disability. Here we report on durable clinical remissions after allogeneic hematopoietic stem cell transplantation in 2 patients suffering from severe forms of the disease. Immunological data evidenced disappearance of the pathogenic antibodies and regeneration of a naive immune system of donor origin. These findings correlated with evident clinical and radiological improvement in both patients, warranting extended clinical trials to investigate this promising therapeutic option. ANN NEUROL 2014;75:447–453 相似文献
43.
44.
Delli Pizzi Andrea Caposiena Daniele Mastrodicasa Domenico Trebeschi Stefano Lambregts Doenja Rosa Consuelo Cianci Roberta Seccia Barbara Sessa Barbara Di Flamminio Filippo Maria Chiacchiaretta Piero Caravatta Luciana Cinalli Sebastiano Di Sebastiano Pierluigi Caulo Massimo Genovesi Domenico Beets-Tan Regina Basilico Raffaella 《Abdominal imaging》2019,44(11):3595-3605
Abdominal Radiology - To compare tumor detectability and conspicuity of standard b = 1000 s/mm2 (b1000) versus ultrahigh b = 2000 s/mm2 (b2000)... 相似文献
45.
Michael J. Eckardt Sandra E. File Gian Luigi Gessa Kathleen A. Grant Consuelo Guerri Paula L. Hoffman Harold Kalant George F. Koob Ting-Kai Li Boris Tabakoff 《Alcoholism, clinical and experimental research》1998,22(5):998-1040
The concept of moderate consumption of ethanol (beverage alcohol) has evolved over time from considering this level of intake to be nonintoxicating and noninjurious, to encompassing levels defined as “statistically” normal in particular populations, and the public health-driven concepts that define moderate drinking as the level corresponding to the lowest overall rate of morbidity or mortality in a population. The various approaches to defining moderate consumption of ethanol provide for a range of intakes that can result in blood ethanol concentrations ranging from 5 to 6 mg/dl, to levels of over 90 mg/dl (i.e., 20 mM). This review summarizes available information regarding the effects of moderate consumption of ethanol on the adult and the developing nervous systems. The metabolism of ethanol in the human is reviewed to allow for proper appreciation of the important variables that interact to influence the level of exposure of the brain to ethanol once ethanol is orally consumed. At the neurochemical level, the moderate consumption of ethanol selectively affects the function of GABA, glutamatergic, serotonergic, dopaminergic, cholinergic, and opioid neuronal systems. Ethanol can affect these systems directly, and/or the interactions between and among these systems become important in the expression of ethanol's actions. The behavioral consequences of ethanol's actions on brain neurochemistry, and the neurochemical effects themselves, are very much dose- and time-related, and the collage of ethanol's actions can change significantly even on the rising and falling phases of the blood ethanol curve. The behavioral effects of moderate ethanol intake can encompass events that the human or other animal can perceive as reinforcing through either positive (e.g., pleasurable, activating) or negative (e.g., anxiolysis, stress reduction) reinforcement mechanisms. Genetic factors and gender play an important role in the metabolism and behavioral actions of ethanol, and doses of ethanol producing pleasurable feelings, activation, and reduction of anxiety in some humans/animals can have aversive, sedative, or no effect in others. Research on the cognitive effects of acute and chronic moderate intake of ethanol is reviewed, and although a number of studies have noted a measurable diminution in neuropsychologic parameters in habitual consumers of moderate amounts of ethanol, others have not found such changes. Recent studies have also noted some positive effects of moderate ethanol consumption on cognitive performance in the aging human. The moderate consumption of ethanol by pregnant women can have significant consequences on the developing nervous system of the fetus. Consumption of ethanol during pregnancy at levels considered to be in the moderate range can generate fetal alcohol effects (behavioral, cognitive anomalies) in the offspring. A number of factors–including gestational period, the periodicity of the mother's drinking, genetic factors, etc.–play important roles in determining the effect of ethanol on the developing central nervous system. A series of recommendations for future research endeavors, at all levels, is included with this review as part of the assessment of the effects of moderate ethanol consumption on the central nervous system 相似文献
46.
Endothelial adhesion molecules ICAM-1, VCAM-1 and E-selectin in patients with acute coronary syndrome 总被引:5,自引:0,他引:5
Macías C Villaescusa R del Valle L Boffil V Cordero G Hernández A Hernández P Ballester JM 《Revista espa?ola de cardiología》2003,56(2):137-144
INTRODUCTION AND OBJECTIVES: The acute inflammatory response is an important phenomenon in the pathogenesis of myocardial damage during acute coronary syndrome. Endothelial dysfunction has been found in unstable angina and acute myocardial infarction, although the results are controversial. The purpose of this study was to determine the levels of the soluble endothelial adhesion molecules ICAM-1, VCAM-1 and E-selectin, in patients with unstable angina and acute myocardial infarction, compare the results in both groups, and analyze their relation with the degree of myocardial injury. METHODS: Serum concentrations of ICAM-1, VCAM-1, and E-selectin were measured in 37 control subjects and 43 patients (32 with acute myocardial infarction and 11 with unstable angina). Measurements were made at the time of admission and ten days later using commercial enzyme-linked immunoabsorbent assay (ELISA) kits (R&D Systems, UK). RESULTS: There was a significant increase in E-selectin (p < 0.05) in patients with unstable angina at admission and ten days later. In contrast, patients with acute myocardial infarction showed no significant differences in E-selectin compared with the control group at admission or ten days later. A significant increase in VCAM-1 levels was demonstrated in both groups of patients and ICAM-1 levels in acute myocardial infarction, but the concentrations of VCAM-1 and ICAM-1 in both groups of patients at admission and ten days later did not differ significantly. There was no relation between soluble endothelial adhesion molecule levels and the severity of myocardial damage estimated by cardiac enzymes or electrocardiographic changes. CONCLUSION: This study indicates that serum levels of E-selectin, measured at time of admission and ten days later, could be a marker for unstable angina and might be useful in the differential diagnosis with myocardial infarction. 相似文献
47.
Incidence of human papillomavirus‐related oropharyngeal cancer and outcomes after chemoradiation in a population of heavy smokers
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48.
Sonia Pérez-Castro Yolanda Lorenzo-Mahía Amparo Iñarrea Fernández María José Lamas-González María Teresa Sarán-Díez Joaquín Rubio-Alarcón María Consuelo Reboredo-Reboredo Sonia Mosteiro-Lobato Isabel López-Miragaya Julio Torres-Piñón Santiago Melón-García 《Enfermedades infecciosas y microbiología clínica》2014
Introduction
The etiology of cervical intraepithelial neoplasia grade 2 or worse (CIN2+) can influence the efficacy of Public Health preventive strategies. This study aimed to determine the high-risk papillomavirus (HR-HPV) prevalence in CIN2+ cases in unvaccinated women in Galicia (Spain), the expected impact of bivalent vaccination, and the distribution of HPV 16 in squamous lesions.Material and methods
Ninety-four histologically confirmed cases of CIN2+ (2009–2010) were retrospectively studied: 23 CIN2, 58 CIN3− squamous carcinoma in situ (CIN3-CIS), 5 adenocarcinoma in situ (AIS), and 8 invasive squamous cervical cancer (SCC). Linear Array HPV Genotyping Test (Roche Diagnostics, Mannheim, Germany) was performed on the cervical specimens. Bivalent vaccination impact was calculated, based on regional vaccination coverage data, local HR-HPV prevalence, and reported efficacy (direct and cross-protection) of the vaccine.Results
HR-HPV prevalence was 96.8%. The most frequent genotypes were HPV 16 (48.8–58.2%) and HPV 31 (9.3%–12.1%), considering single infections or single-multiple infections, respectively (hierarchical attribution). In squamous lesions, HPV 16 prevalence in women younger than 45 years of age increased in severe lesions (CIN3-CIS/SCC, OR 4.2), and was higher than in older women (OR 5.5). The vaccine could reduce the cumulative incidence of CIN2+ by 50.6% (direct protection), or by 62.7% (direct and cross-protection).Conclusion
HPV vaccination could have a great impact in women younger than 45 years of age due to the high prevalence of HPV 16 in their lesions. 相似文献49.
Cytogenomic and phenotypic analysis in low‐level monosomy 7 mosaicism with non‐supernumerary ring chromosome 7
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Consuelo Salas‐Labadía David E. Cervantes‐Barragán Roberto Cruz‐Alcívar Robert D. Daber Laura K. Conlin Laura D. Leonard Nancy B. Spinner Carola Durán‐McKinster David J. Dávila‐Ortíz de Montellano Victoria Del Castillo‐Ruiz Patricia Pérez‐Vera 《American journal of medical genetics. Part A》2014,164(7):1765-1769
50.
The interaction effect between BDNF val66met polymorphism and obesity on executive functions and frontal structure
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![点击此处可从《American journal of medical genetics. Part B, Neuropsychiatric genetics》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Idoia Marqués‐Iturria Maite Garolera Roser Pueyo Bàrbara Segura Imma Hernan Isabel García‐García Consuelo Sánchez‐Garre María Vernet‐Vernet María José Sender‐Palacios Ana Narberhaus Mar Ariza Carme Junqué María Ángeles Jurado 《American journal of medical genetics. Part B, Neuropsychiatric genetics》2014,165(3):245-253