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91.
Fields RC Busam KJ Chou JF Panageas KS Pulitzer MP Allen PJ Kraus DH Brady MS Coit DG 《Annals of surgery》2011,254(3):465-73; discussion 473-5
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Galea Jerome T. Ramos Karen Coit Julia Friedman Lauren E. Contreras Carmen Dueñas Milagros Hernandez Noris Muster Caroline Lecca Leonid Gelaye Bizu 《Maternal and child health journal》2020,24(7):823-828
Maternal and Child Health Journal - Sleep quality and physical activity can affect the mental and physical health of pregnant women and their babies in utero. We investigated the feasibility of... 相似文献
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This prospective study analyzes the neonatal outcome in deliveries complicated by meconium stained amniotic fluid. In a study of 1000 live born deliveries, meconium staining of amniotic fluid was seen in 50 (5%) deliveries. Out of these, 20 newborns (40%) developed classical signs of meconium aspiration syndrome and were managed according to a predetermined protocol. Multiparity, term deliveries, use of sedatives in mother, intrauterine growth retardation and prolonged labour were some of the risk factors for development of meconium aspiration syndrome in newborns. This study highlights the need for review of management protocol in newborns after meconium staining of the amniotic fluid, including the use of prophylactic antibiotics.KEY WORDS: Amniotic fluid, Delivery, Meconium aspiration, Respiratory distress syndrome 相似文献
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Hepatitis B virus e antigen specific epitopes and limitations of commercial anti-HBe immunoassays 总被引:2,自引:0,他引:2
Baumeister MA Medina-Selby A Coit D Nguyen S George-Nascimento C Gyenes A Valenzuela P Kuo G Chien DY 《Journal of medical virology》2000,60(3):256-263
Current commercial hepatitis B virus (HBV) anti-HBe immunoassays are designed so that anti-HBe is detectable only in the absence of excess HBeAg. Recently, with the use of direct anti-HBe assays, anti-HBe was detected in individuals who had been seropositive for several years for HBeAg [Maruyama et al. (1993) J. Clin. Invest. 91:2586-2595]. Although anti-HBe seroconversion does not necessarily indicate subsequent HBeAg clearance, the ability to detect earlier anti-HBe seroconversion could have clinical significance for monitoring patients undergoing HBV immunotherapy (e.g., alpha interferon therapy). Because the HBeAg and the HBcAg share 149 amino acids, an anti-HBe assay must distinguish anti-HBe from anti-HBc antibodies. Although the HBV HBeAg and HBcAg display distinct immunogenic determinants, much remains unknown regarding the complete epitope spectrum specific to each antigen. The goal of this study was 3-fold. The first objective was to identify HBeAg specific linear epitopes. The second objective was to design an anti-HBe immunoassay capable of detecting anti-HBe specific antibody in the presence of excess HBeAg. The third objective was to characterize early anti-HBe seroconversion antibodies. The major linear epitope residing in the HBeAg amino acid sequence was mapped and 2 novel minor epitopes (delta, gamma) which appear to be HBeAg specific have been identified. An anti-HBe immunoassay capable of detecting anti-HBe specific antibody in the presence of excess HBeAg was designed. Finally, it was found that early anti-HBe seroconversion antibodies appear to be conformational, whereas later seroconversion, more typically associated with the clearance of HBeAg, is characterized by the presence of antibodies to the linear HBeAg epitopes. 相似文献
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Fas分子与肝细胞凋亡 总被引:7,自引:4,他引:3
近年来细胞分子生物学领域中的两个重要进展,即细胞凋亡概念的提出和Fas分子的分离与鉴定对肝病的研究有重要影响,加深了人们对肝细胞损伤与死亡的认识.1993年Ogasawaraetal[1]进行的Fas单抗毒性实验证实了Fas分子系统在肝细胞凋亡或损伤... 相似文献
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T. Peter Kingham Katherine S. Panageas Charlotte E. Ariyan Klaus J. Busam Mary Sue Brady Daniel G. Coit 《Annals of surgical oncology》2010,17(2):514-520