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排序方式: 共有424条查询结果,搜索用时 31 毫秒
31.
Antonio Macciò Clelia Madeddu Giulia Gramignano Carlo Mulas Eleonora Sanna Giovanni Mantovani 《The oncologist》2010,15(8):894-902
Advanced‐stage cancer patients often suffer from anemia that closely resembles the anemia of chronic inflammatory diseases characterized by specific changes in iron homeostasis and absorption. i.v. iron improves the efficacy of recombinant human erythropoietin (rHuEPO) in anemic cancer patients undergoing chemotherapy. We report the results of an open‐label, randomized, prospective trial aimed at testing the efficacy and safety of treatment with oral lactoferrin versus i.v. iron, both combined with rHuEPO, for the treatment of anemia in a population of 148 advanced cancer patients undergoing chemotherapy. All patients received s.c. rHuEPO‐β, 30,000 UI once weekly for 12 weeks, and were randomly assigned to ferric gluconate (125 mg i.v. weekly) or lactoferrin (200 mg/day). Both arms showed a significant hemoglobin increase. No difference in the mean hemoglobin increase or the hematopoietic response, time to hematopoietic response, or mean change in serum iron, C‐reactive protein, or erythrocyte sedimentation rate were observed between arms. In contrast, ferritin decreased in the lactoferrin arm whereas it increased in the i.v. iron arm. In conclusion, these results show similar efficacy for oral lactoferrin and for i.v. iron, combined with rHuEPO, for the treatment of anemia in advanced cancer patients undergoing chemotherapy. 相似文献
32.
Stefano Soriani MD ; Caterina Borgna-Pignatti MD ; Elisabetta Trabetti ; Alessandro Casartelli ; Pasquale Montagna MD ; Pier Franco Pignatti MD 《Headache》1999,39(10):779-781
Patients with migraine are known to be at risk for stroke. It has been reported that in a group of patients with cerebral ischemia and the Leiden mutation of factor V, 67% had classical migraine. We have studied the frequency of this mutation in a group of Italian children and adolescents affected by migraine with aura.
The Leiden mutation was detected in 2 (3.5%) of 57 patients and in 8 (3.7%) of 219 controls. The 2 patients carrying the mutation had no peculiar characteristics as compared with the rest of the migrainous population. In our study, the frequency of the Leiden mutation in patients was not different from that of controls. These data contrast with those collected in the Finnish population and in a group of northwestern Italian adult patients, but agree with results previously reported from The Netherlands. 相似文献
The Leiden mutation was detected in 2 (3.5%) of 57 patients and in 8 (3.7%) of 219 controls. The 2 patients carrying the mutation had no peculiar characteristics as compared with the rest of the migrainous population. In our study, the frequency of the Leiden mutation in patients was not different from that of controls. These data contrast with those collected in the Finnish population and in a group of northwestern Italian adult patients, but agree with results previously reported from The Netherlands. 相似文献
33.
34.
Roberta Minelli Vittorio Coiro Maria Antonietta Valli Lorenzo Finardi Clelia Di Seclì Roberto Bertoni Daniele La Gioia Angela Luciana Barilli Carlo Ferrari Gloria Saccani Jotti Roberto Delsignore 《Journal of investigative medicine》2005,53(1):26-30
An association between Graves' disease (GD) and chronic hepatitis C (C-HC) has been observed both in the presence and the absence of recombinant interferon-alpha (rIFN-alpha) treatment. rIFN-alpha-induced GD is characterized by suppressed thyroid-stimulating hormone levels; normal or elevated free triiodothyronine (FT3) and free thyroxine (FT4) values; the presence of thyroid peroxidase antibodies, antithyroglobulin antibodies, and thyroid receptor antibodies; and high iodine thyroid uptake. In contrast, GD developed during C-HC without rIFN-alpha is less clearly defined. In this study, we examined two groups of patients: group A, 28 patients with C-HC treated with rIFN-alpha who developed GD after 1 to 9 months, and group B, 10 patients with C-HC who developed GD without a previous rIFN-alpha treatment. At the time of GD, both groups started methimazole therapy; thyroid function was reevaluated after 3, 6, 9, and 12 months. Group A patients continued IFN. After 12 months, all patients of group A were euthyroid, and 21 of them (75%) had already stopped methimazole treatment, whereas all patients of group B were euthyroid and only 2 (20%) had stopped methimazole. In conclusion, the data show a better course of GD, with a more precocious and significantly higher number of recoveries in patients with rIFN-alpha-induced GD than in rIFN-alpha-unrelated disease. Further studies are needed to establish whether the two types of GD differ not only from a clinical point of view but also because of different underlying pathogenetic mechanisms. 相似文献
35.
María Clelia Mosto Mariana Beatriz Julieta Picasso Martín Miguel Montes Alejandro Martín Tudisca Oliver Krone 《Anatomical record (Hoboken, N.J. : 2007)》2022,305(5):1287-1293
The family Falconidae has contrasting behaviors on its flight within the subfamilies. Falcons are primarily aerial predators requiring accuracy, high speed, and controlled movements during flight. Caracaras are generalists that seek food while walking and their flight is characterized as slow and erratic. We aimed to explore the muscle mass of the primary wing muscles in several species of Falconinae and to identify possible differences related to the role that these muscles perform during flight. We studied 34 wing muscles in 11 specimens of five species of falcons. The percentage of each muscle with respect to body mass was calculated as well as the total wing muscle mass. The search for differences between muscles of falcons and caracaras was analyzed using Bayesian statistical inference. Published data from Polyborinae were used for comparison. Five muscles were significantly different between both subfamilies mm. latissimus dorsi pars caudalis, biceps brachii, extensor carpi radialis, flexor digitorum superficialis, and extensor digitorum communis. The first two muscles were larger in Polyborinae, which could be useful to achieve more strength and stabilization. In falcons the last three muscles listed were larger, which might be associated with their fast and acrobatic flight. Variations in certain muscles generate, in turn, differences in function, which is reflected in their type of flight and its use. These findings reinforce the modular character of the locomotor system of birds whereby the regions involved in locomotion can have morphological peculiarities according to their lifestyle. 相似文献
36.
D’Antongiovanni Vanessa Pellegrini Carolina Benvenuti Laura Fornai Matteo Di Salvo Clelia Natale Gianfranco Ryskalin Larisa Bertani Lorenzo Lucarini Elena Di Cesare Mannelli Lorenzo Ghelardini Carla Nemeth Zoltan H. Haskó György Antonioli Luca 《Inflammation》2022,45(4):1829-1847
Inflammation - The pharmacological blockade of P2X4 receptors has shown potential benefits in the management of several immune/inflammatory diseases. However, data regarding the involvement of P2X4... 相似文献
37.
Gardini A Nardi V Di Stanislao F Brizioli E Mannucci F Melagrani S Cipriani S Giunta S Perfetti C Quagliarini L Rinaldi G Pauri P Scartozzi P Staffolani P Verlicchi G 《Clinica chimica acta; international journal of clinical chemistry》2002,319(2):107-110
The government of the Marche Region has approved an Act called the "Regional Health Plan" establishing rules for the organization and development of healthcare. The main aim of the general plan is to rationalize the activities of medical laboratories first by making up an inventory of existing facilities and tests performed, and by classifying laboratories on the basis of their specialization and the complexity of tests that they perform.Moreover, the possible role of point-of-care testing and the need for clinical advice by laboratory professionals has also been debated. 相似文献
38.
Luca Cantarini Francesca Fanti Mauro Galeazzi Silvana Martino Clelia Miracco Maurizio Biagioli Norberto Dal Canto Rolando Cimaz 《Rheumatology international》2010,30(6):797-799
Weber-Christian Disease (WCD), also known as relapsing febrile lobular non-suppurative panniculitis, is a rare condition characterized
by recurrent subcutaneous inflammatory nodules in the adipose tissue in addition to fever, malaise and other systemic manifestations
such as polyarthralgia and polymyalgia. The association with small vessel vasculitis has been rarely reported. We report here
an unusual case of WCD associated with small vessels vasculitis also describing the efficacy of Cyclosporin A treatment. 相似文献
39.
Santi R Cetica V Franchi A Pepi M Cesinaro AM Miracco C Paglierani M De Giorgi V Delfino C Difonzo EM Pimpinelli N Bianchi S Sardi I Santucci M Massi D 《Histopathology》2011,58(3):455-466
Santi R, Cetica V, Franchi A, Pepi M, Cesinaro A M, Miracco C, Paglierani M, De Giorgi V, Delfino C, Difonzo E M, Pimpinelli N, Bianchi S, Sardi I, Santucci M & Massi D(2011) Histopathology 58 , 455–466 Tumour suppressor gene TP53 mutations in atypical vascular lesions of breast skin following radiotherapy Aims: Atypical vascular lesions (AVL) occurring at the site of radiotherapy represent an uncommon but well‐documented complication in the setting of breast‐conserving therapy for breast carcinoma. Although the biological behaviour of AVL has been regarded as benign, it has been suggested that AVL may represent a precursor of angiosarcoma. A better understanding of the biology of AVL is essential in order to assess appropriate patient management. The aim of the present study was to investigate alterations of tumour suppressor gene TP53 in a series of radiation‐induced AVL and angiosarcomas (AS). Methods and results: Direct sequencing analysis of the TP53 gene showed the presence of at least one variation in 10 of 12 (83.3%) AVL and in seven of eight (87.5%) AS. The most common alteration in both categories was the P72R polymorphism in exon 4. One angiosarcoma sample carried a pathogenetically relevant disruptive mutation c.592delG, a frameshift deletion in exon 6, causing a premature stop codon. Conclusions: The presence of TP53 alterations suggests that its mutational inactivation may be implicated in the pathogenesis of radiation‐associated vascular proliferations. The common mutational pathway suggested by our data supports the hypothesis that AVL and AS are biologically related entities, most probably representing the extremes of a morphological continuum. 相似文献
40.