全文获取类型
收费全文 | 915195篇 |
免费 | 76912篇 |
国内免费 | 5284篇 |
专业分类
耳鼻咽喉 | 13290篇 |
儿科学 | 25430篇 |
妇产科学 | 25857篇 |
基础医学 | 129417篇 |
口腔科学 | 26483篇 |
临床医学 | 81464篇 |
内科学 | 171949篇 |
皮肤病学 | 17567篇 |
神经病学 | 72851篇 |
特种医学 | 37332篇 |
外国民族医学 | 185篇 |
外科学 | 142364篇 |
综合类 | 35226篇 |
现状与发展 | 14篇 |
一般理论 | 266篇 |
预防医学 | 71018篇 |
眼科学 | 21598篇 |
药学 | 70383篇 |
48篇 | |
中国医学 | 5348篇 |
肿瘤学 | 49301篇 |
出版年
2018年 | 8886篇 |
2016年 | 8044篇 |
2015年 | 9928篇 |
2014年 | 13874篇 |
2013年 | 19873篇 |
2012年 | 27054篇 |
2011年 | 28702篇 |
2010年 | 17599篇 |
2009年 | 16348篇 |
2008年 | 26293篇 |
2007年 | 28189篇 |
2006年 | 27869篇 |
2005年 | 27028篇 |
2004年 | 26200篇 |
2003年 | 25232篇 |
2002年 | 24063篇 |
2001年 | 37337篇 |
2000年 | 37598篇 |
1999年 | 31669篇 |
1998年 | 9672篇 |
1997年 | 8971篇 |
1996年 | 8809篇 |
1995年 | 8294篇 |
1994年 | 7977篇 |
1992年 | 26836篇 |
1991年 | 26311篇 |
1990年 | 25765篇 |
1989年 | 24794篇 |
1988年 | 23325篇 |
1987年 | 22968篇 |
1986年 | 21811篇 |
1985年 | 21166篇 |
1984年 | 16433篇 |
1983年 | 14035篇 |
1982年 | 8871篇 |
1981年 | 8221篇 |
1980年 | 7695篇 |
1979年 | 16764篇 |
1978年 | 12145篇 |
1977年 | 10206篇 |
1976年 | 9355篇 |
1975年 | 10167篇 |
1974年 | 12672篇 |
1973年 | 12150篇 |
1972年 | 11550篇 |
1971年 | 10700篇 |
1970年 | 10231篇 |
1969年 | 9925篇 |
1968年 | 8921篇 |
1967年 | 8247篇 |
排序方式: 共有10000条查询结果,搜索用时 468 毫秒
31.
32.
33.
Emma J. Kilford Iroise Dumontheil Nicholas W. Wood Sarah-Jayne Blakemore 《Social cognitive and affective neuroscience》2015,10(6):777-782
The catechol-O-methyltransferase (COMT) enzyme is a major determinant of prefrontal dopamine levels. The Val158Met polymorphism affects COMT enzymatic activity and has been associated with variation in executive function and affective processing. This study investigated the effect of COMT genotype on the flexible modulation of the balance between processing self-generated and processing stimulus-oriented information, in the presence or absence of affective distractors. Analyses included 124 healthy adult participants, who were also assessed on standard working memory (WM) tasks. Relative to Val carriers, Met homozygotes made fewer errors when selecting and manipulating self-generated thoughts. This effect was partly accounted for by an association between COMT genotype and visuospatial WM performance. We also observed a complex interaction between the influence of affective distractors, COMT genotype and sex on task accuracy: male, but not female, participants showed a sensitivity to the affective distractors that was dependent on COMT genotype. This was not accounted for by WM performance. This study provides novel evidence of the role of dopaminergic genetic variation on the ability to select and manipulate self-generated thoughts. The results also suggest sexually dimorphic effects of COMT genotype on the influence of affective distractors on executive function. 相似文献
34.
35.
Sophocarpine attenuates toll‐like receptor 4 in steatotic hepatocytes to suppress pro‐inflammatory cytokines synthesis
下载免费PDF全文
![点击此处可从《Journal of gastroenterology and hepatology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
36.
Simeprevir added to peginterferon and ribavirin lessens time with fatigue,depressive symptoms and functional limitations in patients with chronic hepatitis C compared with peginterferon and ribavirin: results from 1161 patients in the QUEST‐1, QUEST‐2 and PROMISE studies
下载免费PDF全文
![点击此处可从《Journal of viral hepatitis》网站下载免费的PDF全文](/ch/ext_images/free.gif)
J. Scott L. Gilles M. Fu E. Brohan C. Panter R. Arbuckle W. Jessner M. Beumont 《Journal of viral hepatitis》2015,22(8):639-650
The value of adding simeprevir (SMV) vs placebo (PBO) to peginterferon and ribavirin (PR) for treatment of chronic hepatitis C virus infection was examined using patient‐reported outcomes (PROs); further, concordance of PROs with virology endpoints and adverse events (AEs) was explored. Patients (n = 768 SMV/PR, n = 393 PBO/PR) rated fatigue (FSS), depressive symptoms (CES‐D) and functional impairment (WPAI: Hepatitis C Productivity, Daily Activity and Absenteeism) at baseline and throughout treatment in three randomised, double‐blind trials comparing the addition of SMV or PBO during initial 12 weeks of PR. PR was administered for 48 weeks (PBO group) and 24/48 weeks (SMV group) using a response‐guided therapy (RGT) approach. Mean PRO scores (except Absenteeism) worsened from baseline to Week 4 to the same extent in both groups but reverted after Week 24 for SMV/PR and only after Week 48 for PBO/PR. Accordingly, there was a significantly lower area under the curve (baseline–Week 60, AUC60) and fewer weeks with clinically important worsening of scores in the SMV/PR group at any time point. Incidences of patients with fatigue and anaemia AEs were similar in both groups, but FSS scores showed that clinically important increases in fatigue lasted a mean of 6.9 weeks longer with PBO/PR (P < 0.001). PRO score subgroup analysis indicated better outcomes for patients who met the criteria for RGT or achieved sustained virological response 12 weeks post‐treatment (SVR12); differences in mean PRO scores associated with fibrosis level were only observed with PBO/PR. Greater efficacy of SMV/PR enabled reduced treatment duration and reduced time with PR‐related AEs without adding to AE severity. 相似文献
37.
38.
目的:探讨改良三点式重睑术的临床应用疗效。方法:2012年6月-2019年6月,共165例单睑患者采用了改良三点式重睑术,沿术前标记线将三点处皮肤切开,剪刀将切口下唇的眼轮匝肌适当去除,同时将切口与切口在皮下层打通,剪除切口与切口之间的眼轮匝肌,6-0可吸收线挂睑板前筋膜或提上睑肌腱膜及切口下唇皮下组织缝合,三点切口各缝1针。再用6-0单丝尼龙线按照常规重睑线缝合方法挂切口下唇皮肤、睑板前筋膜或提上睑肌腱膜及切口上唇皮肤缝合打结,三点切口各缝1针。伴内眦赘皮者同时行内眦赘皮矫正术。结果:152例患者获得随访,随访患者大部分获得了比较满意的重睑,睁眼重睑流畅、自然,闭眼刀口痕迹不明显。2例患者出现内侧重睑线变浅,1例患者出现外侧重睑线变浅,所有患者均未出现重睑消失。5例患者双侧重睑线有轻度不对称。患者总体满意率为94.7%(144/152)。结论:改良三点式重睑术具有创伤小、并发症少、效果逼真、不易脱落、手术痕迹不明显等优点,值得推广应用。 相似文献
39.
Ahmed M. Abu El-Asrar Ajmal Ahmad Eef Allegaert Mohammad Mairaj Siddiquei Priscilla W. Gikandi Gert De Hertogh 《Ocular immunology and inflammation》2020,28(4):575-588
ABSTRACT
Purpose
To investigate the expression of IL-11 and its receptor IL-11Rα and to quantify density of CD163+ M2 macrophages in proliferative diabetic retinopathy (PDR). 相似文献40.