全文获取类型
收费全文 | 10082篇 |
免费 | 600篇 |
国内免费 | 81篇 |
专业分类
耳鼻咽喉 | 69篇 |
儿科学 | 254篇 |
妇产科学 | 280篇 |
基础医学 | 1404篇 |
口腔科学 | 143篇 |
临床医学 | 773篇 |
内科学 | 2607篇 |
皮肤病学 | 126篇 |
神经病学 | 1469篇 |
特种医学 | 389篇 |
外科学 | 879篇 |
综合类 | 16篇 |
一般理论 | 3篇 |
预防医学 | 457篇 |
眼科学 | 130篇 |
药学 | 770篇 |
中国医学 | 10篇 |
肿瘤学 | 984篇 |
出版年
2024年 | 26篇 |
2023年 | 169篇 |
2022年 | 287篇 |
2021年 | 496篇 |
2020年 | 266篇 |
2019年 | 381篇 |
2018年 | 415篇 |
2017年 | 309篇 |
2016年 | 371篇 |
2015年 | 384篇 |
2014年 | 552篇 |
2013年 | 629篇 |
2012年 | 831篇 |
2011年 | 874篇 |
2010年 | 495篇 |
2009年 | 446篇 |
2008年 | 633篇 |
2007年 | 580篇 |
2006年 | 571篇 |
2005年 | 501篇 |
2004年 | 366篇 |
2003年 | 312篇 |
2002年 | 274篇 |
2001年 | 50篇 |
2000年 | 43篇 |
1999年 | 63篇 |
1998年 | 47篇 |
1997年 | 38篇 |
1996年 | 38篇 |
1995年 | 27篇 |
1994年 | 25篇 |
1993年 | 18篇 |
1992年 | 20篇 |
1991年 | 27篇 |
1990年 | 24篇 |
1989年 | 29篇 |
1988年 | 31篇 |
1987年 | 17篇 |
1986年 | 16篇 |
1985年 | 9篇 |
1984年 | 7篇 |
1983年 | 13篇 |
1982年 | 4篇 |
1981年 | 9篇 |
1980年 | 4篇 |
1979年 | 8篇 |
1978年 | 7篇 |
1977年 | 3篇 |
1974年 | 6篇 |
1966年 | 3篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
112.
Katia Falasca Jacopo Vecchiet Claudio Ucciferri Marta Di Nicola Chiara D’Angelo Marcella Reale 《Nutrients》2015,7(10):8335-8347
Inflammation persists in patients infected with HIV. Reduction of inflammatory cytokines and microbial translocation might be one way that this could be managed. Purpose: The anti-inflammatory properties of certain probiotic strains prompted us to investigate whether a probiotic could reduce the inflammatory index of HIV-infected patients. Methods: The study involved 30 HIV+ males on antiretroviral therapy, who were given one bottle of fermented milk Yakult Light® containing Lactobacillus casei Shirota (LcS) twice a day for four weeks. Results: The probiotic LcS was associated with an increase of T lymphocytes and a significant increase of CD56+ cells (p = 0.04). There was also a significant decrease of mRNA levels of TGFβ, IL-10 and IL-12 (p < 0.001) and IL-1β expression (p < 0.001) and an increase of serum IL-23 (p = 0.03). In addition, decreased inflammation and cardiovascular risk were observed, as shown by a reduction of cystatin C (p < 0.001). Conclusions: These data provide preliminary evidence that probiotic supplementation may modulate certain immunological parameters and some of the cytokines that were analyzed. Thus, we propose that LcS may be an inexpensive and practical strategy to support the immune function of HIV+ patients. 相似文献
113.
114.
Silvio Tocco Paolo Boccolari Antonio Landi Chiara Leonelli Catia Mercanti Francesco Pogliacomi Silvana Sartini Lucia Zingarello Bernadette Nedelec 《Journal of hand therapy》2013,26(3):191-201
Study designRandomized clinical trial.IntroductionAlthough orthotic immobilization has become the preferable treatment choice for closed mallet injuries, it is unclear whether orthosis self-removal has an impact on the final outcome.PurposeTo evaluate the treatment efficacy of cast immobilization of closed mallet fingers using Quickcast® (QC) compared to a removable, lever-type thermoplastic orthosis (LTTP).Methods57 subjects were randomized in 2 groups. DIPj extensor lag and the Gaberman success scale were used as primary outcomes.ResultsLTTP subjects resulted in greater extensor lag than QC subjects (x = 5°; p = 0.05) at 12 weeks from baseline, and high edema and older age negatively affected DIPj extensor lag. No other differences were found between groups.ConclusionCast immobilization seems to be slightly more effective than the traditional approach probably for its greater capacity to reduce edema.Level of evidence1B. 相似文献
115.
Massimo Fusconi Michela Conte Martina Pagliarella Chiara De Vincentiis Armando De Virgilio Anna Teresa Benincasa Simone Alessi Andrea Gallo 《Skull base》2013,74(6):364-368
Objective Fibrous dysplasia (FD) is a benign bone disorder in facial bones. This study evaluates the possibility of diagnosing fibrous dysplasia on imaging alone, without biopsy of the lesion, which is often burdensome for the patient.
Materials and Methods The authors bring their experience of four cases of bone lesions of the maxillofacial region and present a review of published studies. The imaging techniques evaluated are computed tomography (CT) and magnetic resonance imaging (MRI) with and without contrast.
Results The literature review demonstrates that it is impossible to make diagnosis of fibrous dysplasia exclusively by imaging. Radiographic images often show a ground-glass appearance, which is characteristic but not pathognomonic of fibrous dysplasia.
Conclusion Although CT and MRI images may in many cases suggest a diagnosis of fibrous dysplasia, histological examination or follow-up imaging should follow. 相似文献
116.
G. Peluso P. Incollingo N. Carlomagno V. DAlessandro V. Tammaro M. Caggiano M.L. Sandoval Sotelo N. Rupealta M. Candida G. Mazzoni S. Campanile G. Chiacchio A. Scotti M.L. Santangelo 《Transplantation proceedings》2019,51(1):160-163
Background
Patients on peritoneal dialysis treatment represent 15% of the global dialysis population. The major complication of peritoneal dialysis is catheter and peritoneal infection. Peritoneal dialysis patients who receive kidney transplants are at increased risk of infection because of immunosuppressive therapy.Aim
The purpose of this study is to show our ideal timing to remove peritoneal catheter after kidney transplant, which gives adequate security on renal function recovery and reduction of septic risk.Method of Study
We analyzed the outcomes of 65 patients on peritoneal dialysis who underwent kidney transplant between 2000 and 2016.Results
In 61 cases there was an immediate graft functional recovery. In 4 cases there was a delayed graft function (DGF), and we performed a hemodialysis with temporary placement of a venous catheter. In all patients we removed peritoneal dialysis catheter 30 to 45 days after transplant. There has been 1 case of catheter infection, which was treated with antibiotic therapy.Discussion
Our average time to remove the peritoneal dialysis catheter was shorter than times in previous studies, between the 30th and 45th postoperative day. In the 4 cases in which there has been a DGF, we performed hemodialysis treatment to avoid, in the immediate postoperative period, direct insults to the peritoneum by local dialysis procedures.Conclusion
Our experience show that the 30th to 45th postoperative day is a good time frame, better yet a good watershed between the safe removal of peritoneal catheter when patients have a stabilized renal function and the possibility of leaving it in situ, to resume peritoneal dialysis in case of persistent DGF. 相似文献117.
Chiara Grimaldi Arianna Bertocchini Alessandro Crocoli Jean de Ville de Goyet Aurora Castellano Analisa Serra Marco Spada Alessandro Inserra 《Journal of pediatric surgery》2019,54(3):557-561
Background
Complete encasement of the inferior vena cava by retroperitoneal tumors is rare. Although replacement of the vena cava has been considered for various conditions in adults, it is rarely used in children except for challenging resections and as a last chance approach – often aiming more at debulking than cure.Materials and methods
From January 2009 to February 2017, 4 patients (2 adrenal neuroblastomas, 1 renal cell carcinoma, 1 infantile fibrosarcoma) underwent elective en-bloc resection of tumor and of the infrahepatic portion of the inferior vena cava (IVC), with planned IVC prosthetic replacement. In three cases a portion of the left renal vein had to be resected as well, with the vein reanastomosed onto the prosthesis, and a concomitant auto-transplantation of the right kidney was associated in one neuroblastoma patient.Results
All patients had an uncomplicated postoperative course. In one patient, the prosthetic conduit is patent at long-term (43?months), while the middle portion of the prosthesis did eventually thrombose at mid-term after surgery in the three others – with no related symptoms. Interestingly, all renal venous reconstructions remain patent. Three patients (2 neuroblastomas and 1 infantile fibrosarcoma) are alive and disease-free at 43, 74 and 108?months after surgery, respectively. One patient with renal cell carcinoma died of recurrence of the disease 21?months after surgery.Conclusion
Resection and reconstruction of the vena cava, including the renal vein portion, can be considered and planned electively in case of tumoral encasement. This strategy is associated with good tolerance of the operation, low morbidity and satisfactory long-term function, even in cases with progressive and/or secondary partial thrombosis.Level of Evidence
IV 相似文献118.
Lukas Frase Peter Selhausen Lukas Krone Sulamith Tsodor Friederike Jahn Bernd Feige Jonathan G. Maier Florian Mainberger Hannah Piosczyk Marion Kuhn Stefan Klöppel Annette Sterr Chiara Baglioni Kai Spiegelhalder Dieter Riemann Michael A. Nitsche Christoph Nissen 《Brain stimulation》2019,12(3):674-683
Background
Arousal and sleep represent basic domains of behavior, and alterations are of high clinical importance.Objective/hypothesis
The aim of this study was to further elucidate the neurobiology of insomnia disorder (ID) and the potential for new treatment developments, based on the modulation of cortical activity through the non-invasive brain stimulation technique transcranial direct current stimulation (tDCS). Specifically, we tested the hypotheses that bi-frontal anodal tDCS shortens and cathodal tDCS prolongs total sleep time in patients with ID, compared to sham stimulation. Furthermore, we tested for differences in indices of arousal between ID patients and healthy controls and explored their potential impact on tDCS effects.Methods
Nineteen ID patients underwent a within-subject repeated-measures sleep laboratory study with adaptation, baseline and three experimental nights. Bifrontal anodal, cathodal and sham tDCS was delivered in a counterbalanced order immediately prior to sleep. Wake EEG was recorded prior to and after tDCS as well as on the following morning. Subsequently, we compared patients with ID to a healthy control group from an earlier dataset.Results
Against our hypothesis, we did not observe any tDCS effects on sleep continuity or sleep architecture in patients with ID. Further analyses of nights without stimulation demonstrated significantly increased levels of arousal in ID patients compared to healthy controls, as indexed by subjective reports, reduced total sleep time, increased wake after sleep onset and increased high frequency EEG power during wakefulness and NREM sleep. Of note, indices of increased arousal predicted the lack of effect of tDCS in ID patients.Conclusions
Our study characterizes for the first time differential effects of tDCS on sleep in patients with ID and healthy controls, presumably related to persistent hyperarousal in ID. These findings suggest that adapted tDCS protocols need to be developed to modulate arousal and sleep dependent on baseline arousal levels. 相似文献119.