全文获取类型
收费全文 | 2577篇 |
免费 | 555篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 38篇 |
儿科学 | 50篇 |
妇产科学 | 79篇 |
基础医学 | 326篇 |
口腔科学 | 72篇 |
临床医学 | 259篇 |
内科学 | 617篇 |
皮肤病学 | 66篇 |
神经病学 | 189篇 |
特种医学 | 82篇 |
外科学 | 417篇 |
综合类 | 116篇 |
一般理论 | 2篇 |
预防医学 | 187篇 |
眼科学 | 73篇 |
药学 | 173篇 |
中国医学 | 30篇 |
肿瘤学 | 365篇 |
出版年
2023年 | 20篇 |
2022年 | 48篇 |
2021年 | 115篇 |
2020年 | 101篇 |
2019年 | 143篇 |
2018年 | 133篇 |
2017年 | 145篇 |
2016年 | 136篇 |
2015年 | 179篇 |
2014年 | 169篇 |
2013年 | 195篇 |
2012年 | 163篇 |
2011年 | 162篇 |
2010年 | 138篇 |
2009年 | 132篇 |
2008年 | 119篇 |
2007年 | 110篇 |
2006年 | 93篇 |
2005年 | 94篇 |
2004年 | 90篇 |
2003年 | 73篇 |
2002年 | 73篇 |
2001年 | 52篇 |
2000年 | 43篇 |
1999年 | 35篇 |
1998年 | 18篇 |
1997年 | 11篇 |
1996年 | 11篇 |
1995年 | 15篇 |
1994年 | 16篇 |
1993年 | 22篇 |
1992年 | 16篇 |
1991年 | 22篇 |
1990年 | 22篇 |
1989年 | 12篇 |
1988年 | 16篇 |
1987年 | 20篇 |
1986年 | 17篇 |
1985年 | 21篇 |
1984年 | 15篇 |
1983年 | 11篇 |
1982年 | 7篇 |
1981年 | 9篇 |
1979年 | 10篇 |
1978年 | 9篇 |
1974年 | 13篇 |
1973年 | 7篇 |
1972年 | 7篇 |
1971年 | 17篇 |
1970年 | 5篇 |
排序方式: 共有3141条查询结果,搜索用时 15 毫秒
991.
992.
Ellyard JI Chia T Rodriguez-Pinilla SM Martin JL Hu X Navarro-Gonzalez M Garcia JF Delfau-Larue MH Montes-Moreno S Gaulard P Cook MC Walters G Piris MA Vinuesa CG 《Blood》2012,120(4):812-821
Angioimmunoblastic T-cell lymphoma (AITL) is the second most common peripheral T-cell lymphoma with unusual clinical and pathologic features and a poor prognosis despite intensive chemotherapy. Recent studies have suggested AITL derives from follicular helper T (T(FH)) cells, but the causative molecular pathways remain largely unknown. Here we show that approximately 50% of mice heterozygous for the "san" allele of Roquin develop tumors accompanied by hypergammaglobulinemia by 6 months of age. Affected lymph nodes displayed the histologic features diagnostic of AITL, except for the presence of expanded FDC networks. Accumulation of T(FH) cells preceded tumor development, and clonal rearrangements in the TCR-β genes were present in most tumors. Furthermore, T(FH) cells exhibited increased clonality compared with non-T(FH) cells from the same lymph nodes, even in the absence of tumors. Genetic manipulations that prevent T(FH) development, such as deletion of ICOS, CD28, and SAP, partially or completely abrogated tumor development, confirming a T(FH)-derived origin. Roquin(san/+) mice emerge as a useful model to investigate the molecular pathogenesis of AITL and for preclinical testing of therapies aimed at targeting dysregulated T(FH) cells or their consequences. 相似文献
993.
Surgical resection versus transarterial chemoembolization for BCLC stage C hepatocellular carcinoma 下载免费PDF全文
994.
Wendy J. Langeberg Conchitina C. Siozon John H. Page P. K. Morrow Victoria M. Chia 《Supportive care in cancer》2014,22(8):2167-2175
Purpose
This study aims to examine granulocyte colony-stimulating factor (G-CSF) prophylaxis by cancer type, chemotherapy regimen, and cycle in a real-world setting to assess if practice conforms to clinical guidelines, which recommend G-CSF prophylaxis every cycle when a patient’s risk of febrile neutropenia (FN) is 20 % or greater, and to describe the incidence of FN among patients who discontinue pegfilgrastim (peg) prophylaxis.Methods
The cohort was selected from administrative claims data and includes adults diagnosed with non-Hodgkin’s lymphoma (NHL) or breast cancer (BC) who began chemotherapy 2005–2010.Results
About 83.2 % of the 4,470 patients with BC treated with dose-dense doxorubicin, cyclophosphamide (ddAC), 83.6 % of 2,197 patients with BC treated with docetaxel, doxorubicin, cyclophosphamide (TAC), and about 55.6 % of the 2,722 patients with NHL treated with cyclophosphamide, doxorubicin, vincristine, with or without prednisone for 3-week cycles (CHOP-R Q3W) received peg prophylaxis in cycle 1. Among patients on these regimens who received peg prophylaxis in cycle 1 and were still on the regimen in cycle 4, about 90 % received peg prophylaxis in that cycle. Among patients with BC or NHL who discontinued G-CSF, the incidence proportion of infection or FN varied by regimen and cycle, with a range from 0 to 14 %.Conclusions
Despite clinical guidelines recommending G-CSF prophylaxis with chemotherapy regimens with a high risk of FN, many NHL and BC patients do not receive FN prophylaxis in cycle 1. However, among patients who receive G-CSF in cycle 1 and remain on the regimen, the majority appear to continue prophylaxis as indicated. 相似文献995.
996.
Nicholas R. Medjeral-Thomas Michelle M. O’Shaughnessy John A. O’Regan Carol Traynor Michael Flanagan Limy Wong Chia Wei Teoh Atif Awan Mary Waldron Tom Cairns Patrick O’Kelly Anthony M. Dorman Matthew C. Pickering Peter J. Conlon H. Terence Cook 《Clinical journal of the American Society of Nephrology》2014,9(1):46-53
997.
998.
999.
Sungha Park Kazuomi Kario Yook‐Chin Chia Yuda Turana Chen‐Huan Chen Peera Buranakitjaroen Jennifer Nailes Satoshi Hoshide Saulat Siddique Jorge Sison Arieska Ann Soenarta Guru Prasad Sogunuru Jam Chin Tay Boon Wee Teo Yu‐Qing Zhang Jinho Shin Huynh Van Minh Naoko Tomitani Tomoyuki Kabutoya Apichard Sukonthasarn Narsingh Verma Tzung‐Dau Wang Ji‐Guang Wang 《Journal of clinical hypertension (Greenwich, Conn.)》2020,22(3):438-444
Epidemiologic studies have consistently demonstrated an increased risk of cardiovascular disease during colder temperatures. Hemodynamic changes associated with cold temperature and an increase in thrombogenicity may both account for the increase in cardiovascular risk and mortality. Studies using both in‐office and out‐of‐office BP measurements have consistently shown an elevation in BP during the colder seasons. The large difference in BP between cold and warm months may increase the incidence of hypertension and reduce the hypertension control rate, potentially resulting in increased cardiovascular risk, especially among those at risk of cardiovascular disease. The current trends in global warming and climate change may have a profound impact on the epidemiology of hypertension and cardiovascular disease, as changes in the climate may significantly affect both BP variability and cardiovascular disease, especially in those with high cardiovascular risk and the elderly. Furthermore, climate change could have a significant influence on hypertension in Asia, considering the unique characteristics of hypertensive patients in Asia. As an increase in ambient temperature decreases the mean daytime average and morning surge in BP, but increases the nocturnal BP, it is difficult to predict how environmental changes will affect the epidemiology and prognosis of hypertension in the Asian‐Pacific region. However, these seasonal variations in BP could be minimized by adjusting the housing conditions and using anticipation medicine. In this review, we discuss the impact of seasonal variation in the ambient temperature on hypertension and cardiovascular disease and discuss how this may impact the epidemiology of hypertension and cardiovascular disease. 相似文献
1000.
Wee‐Shiong Lim Chih‐Kuang Liang Prasert Assantachai Tung W Auyeung Lin Kang Wei‐Ju Lee Jae‐Young Lim Ken Sugimoto Masahiro Akishita Shu‐Lih Chia Ming‐Yueh Chou Yew‐Yoong Ding Katsuya Iijima Hak C Jang Shuji Kawashima Miji Kim Taro Kojima Masafumi Kuzuya Jenny Lee Sang Y Lee Yunhwan Lee Li‐Ning Peng Ninie Y Wang Yin‐Wei Wang Chang W Won Jean Woo Liang‐Kung Chen Hidenori Arai 《Geriatrics & Gerontology International》2020,20(6):547-558
The coronavirus disease 2019 (COVID‐19) pandemic has casted a huge impact on global public health and the economy. In this challenging situation, older people are vulnerable to the infection and the secondary effects of the pandemic and need special attention. To evaluate the impacts of COVID‐19 on older people, it is important to balance the successful pandemic control and active management of secondary consequences. These considerations are particularly salient in the Asian context, with its diversity among countries in terms of sociocultural heritage, healthcare setup and availability of resources. Thus, the Asian Working Group for Sarcopenia summarized the considerations of Asian countries focusing on responses and difficulties in each country, impacts of health inequity related to the COVID‐19 pandemic and proposed recommendations for older people, which are germane to the Asian context. More innovative services should be developed to address the increasing demands for new approaches to deliver healthcare in these difficult times and to establish resilient healthcare systems for older people. Geriatr Gerontol Int 2020; 20: 547–558 . 相似文献