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排序方式: 共有3682条查询结果,搜索用时 15 毫秒
41.
Chae YB Lee JS Park HJ Park IH Kim MM Park YH Kim DS Lee JH 《Environmental toxicology and pharmacology》2012,34(2):263-271
Advanced adipose-derived stem cell protein extracts (AAPE) were used instead of live stem cells to investigate their effect on oxidative stress and matrix metalloproteinases (MMPs) related to tissue repair in human dermal fibroblasts (HDFs). In this study, it was observed that AAPE at 2μg/ml specifically exhibited scavenging activity of hydrogen peroxide and reducing power. The inhibitory effect of AAPE at 2μg/ml on MMP-2 activity was increased in the presence of phorbol myristate acetate (PMA). In the absence of PMA, AAPE significantly enhanced activities of MMP-1 and MMP-2 in HDFs, respectively. However, the level of MMP-1 expression was decreased in a dose dependent manner by AAPE. In addition, while the level of extracellular signal-regulated kinases 1 (ERK1) activation was reduced in the presence of AAPE compared to blank, the level that of ERK2 activation was not changed. The expression level of c-Fos, a part of activator protein-1 (AP-1), was increased in nucleus of HDFs. These results reveal that activation of MMPs in the presence of AAPE was increased via AP-1 in HDFs, suggesting that AAPE can be a potential candidate for tissue repair. 相似文献
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Byung Woog Kang Jong Gwang Kim Yee Soo Chae Han Ik Bae Ohkyoung Kwon Ho Young Chung Wansik Yu Hong Suk Song Yu Na Kang Seung Wan Ryu Kyung Hee Lee Young Kyung Bae Joon Hyuk Choi Se Won Kim Hun‐Mo Ryoo Chang‐Ho Cho Hyun‐Dong Chae Kyun Woo Park Mi Jin Gu Byung‐Jo Bae 《Asia-Pacific Journal of Clinical Oncology》2014,10(2):e40-e45
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Won Joong Jeon Hee Bok Chae Seon Mee Park Sei Jin Youn Jae Woon Choi Seok Hyoung Kim 《Taehan Sohwagi Hakhoe chi》2006,48(6):438-442
Small cell carcinoma is usually seen in the lung, but rarely involves the gastrointestinal tract including biliary tract. A 65 year-old man was admitted because of obstructive jaundice. A smooth-surfaced round intraluminal mass with proximal bile duct dilatation was seen in the proximal common bile duct on endoscopic retrograde cholangiogram. Under the diagnosis of bile duct cancer, pylorus-preserving pancreatoduodenectomy was done. Pathology revealed a 2 cm sized small cell carcinoma in the proximal common bile duct and distal common hepatic duct. On immunohistochemical stain, the tumor cells were positive for neuroendocrine markers CD56 and synaptophysin. After surgery, the patient received 5 cycles of adjuvant chemotherapy with VIP (etoposide, ifosfamide, and cisplatin) regimen. However, the patient died of liver metastasis 12 months after the diagnosis. We report a case of extrapulmonary small cell carcinoma arising from the common bile duct. 相似文献
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Jeong Hoon Lee Jeong Mi Ha Chae Hun Leem 《The Korean journal of physiology & pharmacology》2015,19(4):373-382
Fura-2 analogs are ratiometric fluoroprobes that are widely used for the quantitative measurement of [Ca2+]. However, the dye usage is intrinsically limited, as the dyes require ultraviolet (UV) excitation, which can also generate great interference, mainly from nicotinamide adenine dinucleotide (NADH) autofluorescence. Specifically, this limitation causes serious problems for the quantitative measurement of mitochondrial [Ca2+], as no available ratiometric dyes are excited in the visible range. Thus, NADH interference cannot be avoided during quantitative measurement of [Ca2+] because the majority of NADH is located in the mitochondria. The emission intensity ratio of two different excitation wavelengths must be constant when the fluorescent dye concentration is the same. In accordance with this principle, we developed a novel online method that corrected NADH and Fura-2-FF interference. We simultaneously measured multiple parameters, including NADH, [Ca2+], and pH/mitochondrial membrane potential; Fura-2-FF for mitochondrial [Ca2+] and TMRE for Ψm or carboxy-SNARF-1 for pH were used. With this novel method, we found that the resting mitochondrial [Ca2+] concentration was 1.03 µM. This 1 µM cytosolic Ca2+ could theoretically increase to more than 100 mM in mitochondria. However, the mitochondrial [Ca2+] increase was limited to ~30 µM in the presence of 1 µM cytosolic Ca2+. Our method solved the problem of NADH signal contamination during the use of Fura-2 analogs, and therefore the method may be useful when NADH interference is expected. 相似文献