Abortion or premature delivery?

This article sets forth the history of the attempt in New South Wales to establish a uniform criterion of stillbirth for statistical purposes. Since 1969, a stillborn infant has been defined as a child of at least 20 weeks gestation or at least 400 gm weight at delivery which has not breathed after delivery. The criterion of life is the presence of a heartbeat after complete expulsion or extraction of the child from its mother. The period of gestation included in the definition of stillbirth represents an attempt to ensure that all infants with the potential for survival are registered. However, since it is not specified whether the period of gestation should be measured as commencing from the time of conception or the 1st day of the last menstrual period, there is a preference for the more objective birthweight measure. In 1978, the World Health Organization recommended that, for statistical purposes, a birthweight of at least 500 gm be the primary criterion for distinguishing between stillbirth and spontaneous abortion. Although this definition is used for the reporting of official Australian perinatal statistics, it has not been approved in New South Wales and some other states.     

Mouse foot-pad inoculation as an aid to the isolation of Leishmania spp. from patients

Portions of splenic or subcutaneous saline aspirates from suspected visceral or cutaneous leishmaniasis patients were inoculated into NNN media with an overlay of Schneider's medium or Schneider's medium alone for routine parasitological diagnosis. The remaining portions of the aspirates were used for preparing Giemsa-stained smears and for subcutaneous inoculation into hind foot-pads of Balb/c mice. Saline aspirates obtained from the foot-pads 2-14 d after inoculation were inoculated into Schneider's medium and examined for promastigotes. Parasite isolation was achieved from 90% of confirmed leishmaniasis patients by either culture method alone. Mouse foot-pad aspiration demonstrated parasites in 95% of all patients, and in over 80% of the confirmed cases of leishmaniasis. Combined culturing and aspirate smear examination was more efficient than foot-pad inoculation alone for the demonstration of leishmanial infection. Foot-pad aspiration does not entail killing animals and was sensitive for parasite isolation; it may be a useful short-term adjunct to existing parasite isolation methods, especially under field conditions where the risks of culture contamination may be high.     

Cardiac pacemakers and central venous lines can induce focal artifacts on CT-corrected PET images.

PET/CT imaging can be associated with focal artifactual (18)F-FDG uptake introduced by metallic implants or contrast agents. It is unknown whether cardiac pacemakers or permanent central venous catheters can also result in such artifacts. METHODS: Twenty-seven patients with permanent central venous lines (13 men and 14 women; mean age +/- SD, 53.8 +/- 16.2 y) and 9 patients with pacemakers (7 men and 2 women; mean age +/- SD, 74.8 +/- 5.1 y) who were referred for a variety of oncologic indications were studied with lutetium-oxyorthosilicate-based dual-slice PET/CT after injection of 7.77 MBq/kg of (18)F-FDG. CT-corrected and -uncorrected PET images were reviewed, and (18)F-FDG uptake was graded as absent, mild, moderate, or intense. RESULTS: CT-corrected PET images revealed focally increased uptake of moderate intensity in all patients with cardiac pacemakers and focally increased uptake of mild intensity in 8 of 27 patients (29.6%) with central venous lines. CONCLUSION: Cardiac pacemakers and reservoirs of central venous lines can induce artifactual (18)F-FDG on CT-corrected PET images. Thus, in patients with permanent central lines or pacemakers, both corrected and uncorrected PET images need to be reviewed to avoid false-positive PET findings.     

Teaching medical ethics during residency

Because practicing physicians are poorly prepared to resolve many ethical issues that arise in patient care, this article proposes that residencies include practical training in medical ethics. Training in medical ethics helps physicians recognize ethical issues in patient care and resolve those issues wisely. Furthermore, such training has its maximum impact during the professionally formative years of residency. The article specifies key ethical concepts residents should know, including knowing how to obtain informed consent, knowing what to do about incompetent patients, knowing when to withhold or disclose clinical information, and knowing how to use resources properly. The article also points out that the success of residency training in ethics depends on strong commitments from the department: endorsement by the chairman and the residency program director; recruitment of several dedicated faculty; support for adequate ethics training for these faculty; dedication of conferences, rounds, and consultations to teaching ethics; and allocation of sufficient funds.