全文获取类型
收费全文 | 1048篇 |
免费 | 61篇 |
国内免费 | 59篇 |
专业分类
儿科学 | 45篇 |
妇产科学 | 9篇 |
基础医学 | 64篇 |
口腔科学 | 13篇 |
临床医学 | 155篇 |
内科学 | 262篇 |
皮肤病学 | 17篇 |
神经病学 | 25篇 |
特种医学 | 232篇 |
外科学 | 159篇 |
综合类 | 36篇 |
预防医学 | 44篇 |
眼科学 | 8篇 |
药学 | 53篇 |
中国医学 | 2篇 |
肿瘤学 | 44篇 |
出版年
2023年 | 5篇 |
2022年 | 6篇 |
2021年 | 17篇 |
2020年 | 5篇 |
2019年 | 11篇 |
2018年 | 17篇 |
2017年 | 9篇 |
2015年 | 18篇 |
2014年 | 25篇 |
2013年 | 40篇 |
2012年 | 22篇 |
2011年 | 26篇 |
2010年 | 27篇 |
2009年 | 23篇 |
2008年 | 19篇 |
2007年 | 55篇 |
2006年 | 15篇 |
2005年 | 24篇 |
2004年 | 20篇 |
2003年 | 16篇 |
2002年 | 15篇 |
2001年 | 12篇 |
2000年 | 13篇 |
1999年 | 15篇 |
1998年 | 56篇 |
1997年 | 36篇 |
1996年 | 62篇 |
1995年 | 46篇 |
1994年 | 41篇 |
1993年 | 49篇 |
1992年 | 11篇 |
1991年 | 19篇 |
1990年 | 24篇 |
1989年 | 38篇 |
1988年 | 49篇 |
1987年 | 42篇 |
1986年 | 30篇 |
1985年 | 39篇 |
1984年 | 24篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 23篇 |
1980年 | 20篇 |
1979年 | 7篇 |
1978年 | 11篇 |
1977年 | 18篇 |
1976年 | 10篇 |
1975年 | 10篇 |
1974年 | 4篇 |
1966年 | 3篇 |
排序方式: 共有1168条查询结果,搜索用时 15 毫秒
61.
Insufficiency fractures in the supraacetabular region were identified in five women, aged 55-83 years. Factors contributing to the diminished resistance of their bones included postmenopausal osteoporosis, steroid therapy, radiation therapy, and rheumatoid arthritis. The supraacetabular fractures were seen on routine radiographs as hazy bands of sclerosis located immediately above and parallel to the acetabular roof. All five patients had additional fractures in the spine or pelvis. Supraacetabular insufficiency fractures may be an unsuspected cause of hip pain, especially in older women. 相似文献
62.
63.
64.
LeRoy AJ; Williams HJ Jr; Bender CE; Segura JW; Patterson DE; Benson RC 《Radiology》1985,155(1):83-85
Two patients had colonic perforation as a result of percutaneous nephrostomy placement followed by track dilatation and renal calculus removal. We present the technical aspects of nephrostomy placement and stone removal, as well as the clinical diagnosis and management of these cases. Both patients recovered well with conservative therapy and required no surgical intervention. This report reviews the anatomic considerations for percutaneous nephrostomy in patients undergoing renal stone removal. 相似文献
65.
66.
The development of cancer occurs in a stepwise fashion, with each step representing the mutation in one of several key genes. However, the mutation rate of somatic cells is too low to account for the number of mutations required for a cell to undergo carcinogenesis. Thus, the development of genetic instability is a vital early step towards carcinogenesis. We review the evidence for genetic instability, with particular reference to transitional cell carcinoma of the bladder. Both microsatellite instability and chromosomal instability are present in this tumour, and we discuss their incidence and clinical implications. 相似文献
67.
Arterial hypertension is a major cause of morbidity and mortalitybecause of its association with coronary heart disease, cerebrovasculardisease and renal disease. The extent of target organ involvement(i.e. heart, brain and kidneys) determines outcome. North Americanstudies have shown that hypertension is a major contributorto 500 000 strokes (250 000 deaths) and 1 000 000 myocardialinfarctions (500 000 deaths) per annum. 相似文献
68.
Calvert NW Morgan AB Catto JW Hamdy FC Akehurst RL Mouncey P Paisley S 《British journal of cancer》2003,88(1):31-35
This paper demonstrates how economic modelling can be used to derive estimates of the cost-effectiveness of prognostic markers in the management of clinically localised and moderately graded prostate cancer. The model uses a Markov process and is populated using published evidence and local data. The robustness of the results has been tested using sensitivity analysis. Three treatment policies of 'monitoring' (observation), radical prostatectomy, or a selection-based management policy using DNA-ploidy as an experimental marker, have been evaluated. Modelling indicates that a policy of managing these tumours utilising experimental markers has an estimated cost per quality-adjusted life year (QALY) of pound 12 068. Sensitivity analysis shows the results to be relatively sensitive to quality-of-life variables. If novel and experimental markers can achieve specificity in excess of 80%, then a policy of radical surgery for those identified as being at high risk and conservative treatment for the remainder would be both better for patients and cost-effective. The analysis suggests that a radical prostatectomy treatment policy for the moderately graded tumours (Gleason grades -7) modelled in this paper may be inferior to a conservative approach in the absence of reliable prognostic markers, being both more costly and yielding fewer QALYs. 相似文献
69.
Cefalu WT; Wagner JD; Bell-Farrow AD; Edwards IJ; Terry JG; Weindruch R; Kemnitz JW 《Toxicological sciences》1999,52(2):49-55
Caloric restriction (CR) has been observed to retard aging processes and
extend the maximum life span in rodents. In an effort to evaluate the
effect of this nutritional intervention on physiologic variables in higher
species, several nonhuman primate trials are ongoing. In particular, a
study evaluating the independent effect of CR on the extent of
atherosclerosis was initiated in 1993 in 32 adult cynomolgus monkeys.
Therefore, the trial was designed to achieve identical cholesterol intake
after animals were randomized to a control group or a calorie-restricted
group (30% reduction from baseline caloric intake). The animals were
routinely evaluated for glycated proteins, plasma insulin and glucose
levels, insulin sensitivity, and specific measures for abdominal fat
distribution by CT scans over a 4-year interval. The results from 4 years
of intervention demonstrate that CR improves cardiovascular risk factors
(such as visceral fat accumulation) and improves insulin sensitivity. In
contrast to other primate studies with normolipidemic animals, CR had no
independent effects on plasma lipid levels and composition in the presence
of equivalent amounts of dietary cholesterol intake. Preliminary analysis
of atherosclerotic lesion extent in the abdominal aorta has failed to
demonstrate differences between control animals and CR animals. Follow- up
studies are being conducted to determine the effect of CR on
atherosclerosis extent in coronary and carotid arteries.
相似文献
70.