全文获取类型
收费全文 | 76960篇 |
免费 | 7300篇 |
国内免费 | 165篇 |
专业分类
耳鼻咽喉 | 890篇 |
儿科学 | 2554篇 |
妇产科学 | 2219篇 |
基础医学 | 11361篇 |
口腔科学 | 1451篇 |
临床医学 | 10209篇 |
内科学 | 14503篇 |
皮肤病学 | 1216篇 |
神经病学 | 7067篇 |
特种医学 | 2177篇 |
外国民族医学 | 1篇 |
外科学 | 9144篇 |
综合类 | 1244篇 |
一般理论 | 61篇 |
预防医学 | 8426篇 |
眼科学 | 1222篇 |
药学 | 5506篇 |
中国医学 | 117篇 |
肿瘤学 | 5057篇 |
出版年
2023年 | 402篇 |
2022年 | 629篇 |
2021年 | 1517篇 |
2020年 | 975篇 |
2019年 | 1630篇 |
2018年 | 1813篇 |
2017年 | 1281篇 |
2016年 | 1529篇 |
2015年 | 1601篇 |
2014年 | 2233篇 |
2013年 | 3339篇 |
2012年 | 4728篇 |
2011年 | 4837篇 |
2010年 | 2700篇 |
2009年 | 2315篇 |
2008年 | 4019篇 |
2007年 | 4274篇 |
2006年 | 4152篇 |
2005年 | 3987篇 |
2004年 | 3672篇 |
2003年 | 3484篇 |
2002年 | 3448篇 |
2001年 | 1785篇 |
2000年 | 1761篇 |
1999年 | 1592篇 |
1998年 | 925篇 |
1997年 | 788篇 |
1996年 | 641篇 |
1995年 | 654篇 |
1994年 | 587篇 |
1993年 | 590篇 |
1992年 | 1223篇 |
1991年 | 1140篇 |
1990年 | 1097篇 |
1989年 | 1012篇 |
1988年 | 950篇 |
1987年 | 938篇 |
1986年 | 911篇 |
1985年 | 924篇 |
1984年 | 757篇 |
1983年 | 653篇 |
1982年 | 479篇 |
1981年 | 391篇 |
1980年 | 410篇 |
1979年 | 611篇 |
1978年 | 475篇 |
1977年 | 385篇 |
1976年 | 385篇 |
1974年 | 393篇 |
1972年 | 352篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
12.
13.
14.
15.
T. Wu L. G. Trahair M. J. Bound C. F. Deacon M. Horowitz C. K. Rayner K. L. Jones 《Diabetic medicine》2015,32(5):595-600
16.
17.
David M. Presby Michael C. Rudolph Vanessa D. Sherk Matthew R. Jackman Rebecca M. Foright Kenneth L. Jones Julie A. Houck Ginger C. Johnson Janine A. Higgins P. Darrell Neufer Robert H. Eckel Paul S. MacLean 《Diabetes》2021,70(4):867
Moderate weight loss improves numerous risk factors for cardiometabolic disease; however, long-term weight loss maintenance (WLM) is often thwarted by metabolic adaptations that suppress energy expenditure and facilitate weight regain. Skeletal muscle has a prominent role in energy homeostasis; therefore, we investigated the effect of WLM and weight regain on skeletal muscle in rodents. In skeletal muscle of obesity-prone rats, WLM reduced fat oxidative capacity and downregulated genes involved in fat metabolism. Interestingly, even after weight was regained, genes involved in fat metabolism were also reduced. We then subjected mice with skeletal muscle lipoprotein lipase overexpression (mCK-hLPL), which augments fat metabolism, to WLM and weight regain and found that mCK-hLPL attenuates weight regain by potentiating energy expenditure. Irrespective of genotype, weight regain suppressed dietary fat oxidation and downregulated genes involved in fat metabolism in skeletal muscle. However, mCK-hLPL mice oxidized more fat throughout weight regain and had greater expression of genes involved in fat metabolism and lower expression of genes involved in carbohydrate metabolism during WLM and regain. In summary, these results suggest that skeletal muscle fat oxidation is reduced during WLM and regain, and therapies that improve skeletal muscle fat metabolism may attenuate rapid weight regain. 相似文献
18.
Gastro-oesophageal reflux disease (GORD) is symptomatic reflux of gastric contents into the oesophagus. Factors predisposing to GORD are loss of the physiological antireflux barrier and anatomic abnormalities of the oesophagus or diaphragm. Conservative measures and medical management results in resolution of symptoms in a majority of children. Surgery is indicated in the event of failure of medical management or severe complications. Surgical procedures include open or laparoscopic fundoplication in children with normal neurology; fundoplication with or without vagotomy and pyloroplasty; surgical feeding jejunostomy and oesophago-gastric dissociation in the severely neurologically impaired children. 相似文献
19.
Angela J. Jacques-Tiura Deborah A. Ellis April Idalski Carcone Sylvie Naar Kathryn Brogan Hartlieb Elizabeth K. Towner Thomas N. Templin K.-L. Catherine Jen 《The Journal of adolescent health》2019,64(3):355-361
Objective
Successful weight loss interventions for African-Americans adolescents are lacking. Cognitive-behavioral interventions seek to develop weight loss skills (e.g., counting calories, goal setting, managing one's environment). Little is known about how well adolescents implement such skills in their daily lives. Study aims were to (1) examine weight loss skills utilization at midpoint and end of a 6-month cognitive-behavioral/motivational interviewing weight loss sequential multiple assignment randomized trial (SMART), and (2) determine if greater skill utilization predicted weight loss at treatment end and 3 months post-treatment.Method
One hundred and eighty six African-Americans adolescents with obesity and their caregiver were first randomly assigned to complete 3 months of cognitive-behavioral and motivational interviewing family-based weight loss treatment in their home or in the research office (Phase 1). Nonresponders (i.e., those who lost < 3% of initial weight, n?=?161) were rerandomized to 3 months of continued skills training (n?=?83) or contingency management (n?=?78) for Phase 2; responders were allocated to 3 months of relapse prevention (n?=?20). Adolescents’ frequency of weight loss skills utilization was assessed via questionnaire at treatment midpoint and end.Results
Higher treatment attendance was associated with better skill utilization. Higher skill utilization was associated with more weight loss at treatment end, whereas higher baseline confidence was associated with more weight loss at follow-up.Conclusions
This study indicates the importance of attending weight loss intervention sessions to develop and strengthen weight loss skills in African-American adolescents with obesity, and strengthening confidence to use such skills for continued weight loss. 相似文献20.
Paola Gilsanz Maria M. Corrada Claudia H. Kawas Elizabeth Rose Mayeda M. Maria Glymour Charles P. Quesenberry Catherine Lee Rachel A. Whitmer 《Alzheimer's & dementia》2019,15(4):497-505