全文获取类型
收费全文 | 81703篇 |
免费 | 4789篇 |
国内免费 | 1212篇 |
专业分类
耳鼻咽喉 | 702篇 |
儿科学 | 1967篇 |
妇产科学 | 2163篇 |
基础医学 | 9614篇 |
口腔科学 | 1566篇 |
临床医学 | 6933篇 |
内科学 | 19649篇 |
皮肤病学 | 1500篇 |
神经病学 | 7690篇 |
特种医学 | 2745篇 |
外国民族医学 | 2篇 |
外科学 | 10856篇 |
综合类 | 2198篇 |
现状与发展 | 1篇 |
一般理论 | 16篇 |
预防医学 | 4985篇 |
眼科学 | 1235篇 |
药学 | 6177篇 |
8篇 | |
中国医学 | 1077篇 |
肿瘤学 | 6620篇 |
出版年
2023年 | 699篇 |
2022年 | 1697篇 |
2021年 | 2724篇 |
2020年 | 1693篇 |
2019年 | 2035篇 |
2018年 | 2333篇 |
2017年 | 1846篇 |
2016年 | 1972篇 |
2015年 | 2380篇 |
2014年 | 3198篇 |
2013年 | 4012篇 |
2012年 | 5680篇 |
2011年 | 5911篇 |
2010年 | 3385篇 |
2009年 | 3065篇 |
2008年 | 4943篇 |
2007年 | 5004篇 |
2006年 | 4598篇 |
2005年 | 4416篇 |
2004年 | 4050篇 |
2003年 | 3596篇 |
2002年 | 3241篇 |
2001年 | 1637篇 |
2000年 | 1493篇 |
1999年 | 1466篇 |
1998年 | 736篇 |
1997年 | 585篇 |
1996年 | 572篇 |
1995年 | 467篇 |
1994年 | 391篇 |
1993年 | 344篇 |
1992年 | 790篇 |
1991年 | 663篇 |
1990年 | 620篇 |
1989年 | 641篇 |
1988年 | 527篇 |
1987年 | 489篇 |
1986年 | 464篇 |
1985年 | 366篇 |
1984年 | 320篇 |
1983年 | 272篇 |
1982年 | 162篇 |
1981年 | 148篇 |
1980年 | 144篇 |
1979年 | 235篇 |
1978年 | 147篇 |
1977年 | 135篇 |
1974年 | 142篇 |
1973年 | 135篇 |
1972年 | 129篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
61.
Hilda A. Perez Carmen Bracho Mirtha Romano Mercedes De la Rosa 《Parasitology research》1997,83(3):246-251
A monoclonal antibody raised by immunization of BALB/c mice with erythrocytic stages of Plasmodium vivax was shown to react with asexual erythrocytic stages of P. chabaudi. The cross-reactivity molecules are antigens of 200 and 148 kDa in P. vivax and of 190 and 70 kDa in P. chabaudi. Immunofluorescence studies of the erythrocytic stages of P. vivax and P. chabaudi indicated that expression of these antigens increased as the parasites' developed from the ring stage to the schizont stage.
In the mature trophozoites of P. chabaudi, immunoelectron microscopy revealed clusters of antigen distributed in the cytoplasm of the parasitized erythrocyte. In the
schizont, packets of antigen were found associated with the parasitophorous vacuole and the cytoplasm of the infected host
cell.
Received: 19 March 1996 / Accepted: 28 August 1996 相似文献
62.
63.
A. Robert Spitzer Shalom Stahl David Yarnitsky Ernest W. Johnson John R. Wilson R. A. C. Hughes Stefania Morino Giovanni Antonini Kiyotoshi Kaneko Yoji Ohnishi Tetsushi Atsumi Isao Hozumi Tadashi Miyatake Tetsuo Furukawa James P. Knochel Ikuo Mineo Seiichiro Tarui Francis O. Walker Andrew J. Gitter Walter C. Stolov Nicholas J. Capozzoli 《Muscle & nerve》1996,19(4):531-538
64.
65.
Franco Rilke M. D. F. R. C. Umberto Veronesi M. D. Alberto Luini M. D. Cristina Brambilla M. D. Viviana Galimberti M. D. Stefano Zurrida M. D. Silvana Pilotti M. D. M. I. A. C. Silvana Di Palma M. D. Roberto Zucali M. D. Laura Lozza M. D. 《The breast journal》1996,2(3):176-180
Abstract: Breast conservation surgery is an effective and safe treatment for many breast carcinomas. It may be possible to further limit the extent of resection (or expand the indication for breast conservation) by the application of preoperative chemotherapy and radiotherapy. We explored the feasibility of this in a pilot study.
Seventy-three patients (mean age 48, 63% premenopausal) with confirmed breast cancer, less than 2.5 cm, received chemotherapy (Group A) or chemotherapy plus radiotherapy (Group B) prior to limited resection (tumorectomy). Axillary dissection was always performed. Results: In 6/31 (19%) Group A and 17/42 (40%) Group B patients the tumor was not palpable after preoperative treatment, with complete pathological remission in 1 and 3 cases respectively. Histologic grading, mitosis, cellular alteration, and cellularity evaluations indicated a consistently greater therapeutic effect with chemoradiotherapy than with chemotherapy alone.
In conclusion, radiotherapy appears useful in the preoperative treatment of breast cancer and its use in association with various drug combinations should be further explored. 相似文献
Seventy-three patients (mean age 48, 63% premenopausal) with confirmed breast cancer, less than 2.5 cm, received chemotherapy (Group A) or chemotherapy plus radiotherapy (Group B) prior to limited resection (tumorectomy). Axillary dissection was always performed. Results: In 6/31 (19%) Group A and 17/42 (40%) Group B patients the tumor was not palpable after preoperative treatment, with complete pathological remission in 1 and 3 cases respectively. Histologic grading, mitosis, cellular alteration, and cellularity evaluations indicated a consistently greater therapeutic effect with chemoradiotherapy than with chemotherapy alone.
In conclusion, radiotherapy appears useful in the preoperative treatment of breast cancer and its use in association with various drug combinations should be further explored. 相似文献
66.
67.
Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection 总被引:1,自引:0,他引:1
Marisa Giani Alberto Edefonti Beatrice Damiani Giuseppina Marra Daniela Colombo Giovanni Banfi Emilio Rivolta Erich H. Strøm Michael Mihatsch 《Pediatric nephrology (Berlin, Germany)》1996,10(1):73-75
This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear: NS may represent another manifestation of CMV disease. 相似文献
68.
This report is a retrospective clinical randomized study carried out on 114 cases of incidental prostatic carcinoma aged 55-87 years, 58 untreated and 56 treated with cyproterone acetate (CPA 200 mg/day) for 6 months, immediately after surgery. 78 cases were staged A1 and the remaining 36 A2. In stage A1, 75 cases were histologically graded G1, and 3 G2, whereas in stage A2, 7 cases were G1, 19 G2 and 10 G3. Moreover, flow cytometric DNA analysis showed in A1 20 G1 carcinomas with nuclear diploidy and 3 G2 with nuclear aneuploidy, in stage A2, 4 G3 tumors with nuclear aneuploidy. During the 4-year follow-up, 25/28 patients of the untreated group and 15/56 of the CPA-treated group were found in progression. In A1, progression was found in 6/37 untreated patients and 5/41 CPA-treated, whilst in A2 progression was observed in 19/21 untreated patients and in 10/15 treated with CPA. The critical period for progression was between the 2nd and 3rd year of follow-up. In A1, therefore, 6 months of therapy with CPA does not modify the progression rate, which is significantly improved in A2 (66% in the treated and 90% in the untreated group) during the first 30 months of follow-up. The prognosis may probably be further improved by continuing endocrine therapy. 相似文献
69.
E Cianchetti R Cotellese A Dell'Osa M Nardi A D'Aulerio L Puglielli P Di Sebastiano C Saragani A M Napolitano 《Minerva chirurgica》1990,45(17):1093-1096
A case series of 5 male patients afflicted with breast carcinoma is reported. The Authors describe symptomatology, diagnostic iter, principles of surgical treatment and results. Underlined is the wider surgical demolition in male breast cancer in comparison with females, even if natural history and biological conduct are comparable. This is because in male breast carcinoma the local and remote infiltration is more rapid than female for the less development of breast gland. Finally, indications for radiochemotherapy are comparable to female breast cancer. 相似文献
70.
大鼠肝细胞Ⅰ,Ⅲ型前胶原基因表达及PDGF的影响 总被引:3,自引:1,他引:2
目的观察大鼠肝细胞Ⅰ,Ⅲ型前胶原基因的表达及PDGF对其表达的影响.方法应用原位杂交技术检测分离培养的SD大鼠肝细胞(n=30)内Ⅰ,Ⅲ型前胶原基因的表达.同时观察10μg/L(n=30)和30μg/L(n=30)PDGF促进前胶原基因表达的作用.测定基因表达颗粒总面积占细胞总面积的百分比,并作比较分析.结果无论正常肝细胞或是在两种浓度的PDGF存在时,肝细胞内均可见到Ⅰ,Ⅲ型前胶原基因的表达.正常肝细胞Ⅰ,Ⅲ型前胶原基因表达面积的百分比(%)为77±19和75±21;加10μg/LPDGF后为115±19和112±10,而加30μg/L后为152±34及181±28,且在后者中表达明显增强(P<005及P<001).结论PDGF在转录水平上促进肝细胞胶原的合成. 相似文献