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61.
As many as 29% of women suffer from migraine headache, yet it remains a poorly understood phenomenon. Our purpose in conducting this pilot study was to determine the relationships among migraine pain, disability, depressive symptomatology, and coping in women. A convenience sample of 34 women was recruited from university and workplace populations. Nineteen women met the International Headache Society criteria for migraine, while 15 women served as a nonmigraine comparison group. Participants completed eight instruments measuring migraine pain, disability, depressive symptomatology, and coping. The two groups of women were not significantly different on demographic variables. Migraineurs scored significantly higher for pain characteristics, disability, depressive symptomatology, and total coping scores. 相似文献
62.
Camille Daste François Rannou Luc Mouthon Katherine Sanchez Alexandra Roren Vincent Tiffreau Éric Hachulla Philippe Thoumie Jean Cabane Emmanuel Chatelus Jean Sibilia Serge Poiraudeau Christelle Nguyen 《Seminars in arthritis and rheumatism》2019,48(4):694-700
Background
To estimate patient acceptable symptom state (PASS) and minimal clinically important difference (MCID) for patient-reported outcomes in systemic sclerosis (SSc).Methods
We conducted a secondary analysis of the SCLEREDUC trial, a 12-month randomized controlled trial comparing the efficacy of physical therapy to usual care in 220 SSc patients followed-up from September 2005 to October 2010. Self-rated state and change in patient health at 12 months were assessed by using 2 external anchors extracted from the Medical Outcomes Study 36-Item Short-Form. Patients who self-rated their health as “excellent”, “very good” or “good” were the PASS group and those who self-rated their health change as “somewhat better” were the MCID group. Main outcomes were the estimates of PASS by using the 75th percentile method and of MCID by using the mean change in scores method for pain and activity limitation.Results
PASS (95% confidence interval) and mean (SD) MCID estimates at 12 months were 53.75 (34.00 to 68.00) and ?6.74 (32.02) for the joint-pain visual analog scale (range 0–100), 1.41 (1.13 to 1.63) and ?0.21 (0.48) for the Health Assessment Questionnaire (HAQ, range 0–3), 1.27 (1.07 to 1.62) and ?0.13 (0.45) for the scleroderma HAQ (range 0–3), 26.00 (17.00 to 37.00) and -3.38 (9.87) for the Cochin Hand Function Scale (range 0–90), and 19.40 (17.20 to 21.90) and ?5.69 (6.79) for the McMaster-Toronto Arthritis Patient Preference Disability Questionnaire (range 0–30), respectively.Conclusions
We provide, for the first time, the PASS and MCID estimates for pain and activity limitation in SSc.63.
Brian D. Wright Michael C. Deblock Patrick O. Wagers Ernest Duah Nikki K. Robishaw Kerri L. Shelton Marie R. Southerland Michael A. DeBord Kortney M. Kersten Lucas J. McDonald Jason A. Stiel Matthew J. Panzner Claire A. Tessier Sailaja Paruchuri Wiley J. Youngs 《Medicinal chemistry research》2015,24(7):2838-2861
64.
Pascal Delsart Camille Delahaye Patrick Devos Olivia Domanski Richard Azzaoui Jonathan Sobocinski Francis Juthier Andre Vincentelli Natacha Rousse Agnes Mugnier Jerome Soquet Valentin Loobuyck Mohamed Koussa Thomas Modine Bruno Jegou Antoine Bical Ilir Hysi Olivier Fabre Franois Pontana Regis Matran Claire MounierVehier David Montaigne 《Clinical cardiology》2021,44(2):252
BackgroundAlthough recommendations encourage daily moderate activities in post aortic dissection, very little data exists regarding cardiopulmonary exercise testing (CPET) to personalize those patient''s physical rehabilitation and assess their cardiovascular prognosis.DesignWe aimed at testing the prognostic insight of CPET regarding aortic and cardiovascular events by exploring a prospective cohort of patients followed‐up after acute aortic dissection.MethodsPatients referred to our department after an acute (type A or B) aortic dissection were prospectively included in a cohort between September 2012 and October 2017. CPET was performed once optimal blood pressure control was obtained. Clinical follow‐up was done after CPET for new aortic event and major cardio‐vascular events (MCE) not directly related to the aorta.ResultsAmong the 165 patients who underwent CPET, no adverse event was observed during exercise testing. Peak oxygen pulse was 1.46(1.22‐1.84) mlO2/beat, that is, 97 (83–113) % of its predicted value, suggesting cardiac exercise limitation in a population under beta blockers (92% of the population). During a follow‐up of 39(20‐51) months from CPET, 42 aortic event recurrences and 22 MCE not related to aorta occurred. Low peak oxygen pulse (<85% of predicted value) was independently predictive of aortic event recurrence, while low peak oxygen uptake (<70% of predicted value) was an independent predictor of MCE occurrence.ConclusionCPET is safe in postaortic dissection patients should be used to not only to personalize exercise rehabilitation, but also to identify those patients with the highest risk for new aortic events and MCE not directly related to aorta. 相似文献
65.
66.
Pediatric patients who receive antibiotics for fever and neutropenia in less than 60 min have decreased intensive care needs
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Jennifer L. Salstrom MD PhD Rebecca L. Coughlin MEd Kathleen Pool MSN CPNP Melissa Bojan BSN Camille Mediavilla BSN William Schwent MBA Michael Rannie MS Dawn Law MBA Michelle Finnerty BS Joanne Hilden MD 《Pediatric blood & cancer》2015,62(5):807-815
Background
Antibiotic delivery to patients with fever and neutropenia (F&N) in <60 min is an increasingly important quality measure for oncology centers, but several published reports indicate that a time to antibiotic delivery (TTA) of <60 min is quite difficult to achieve. Here we report a quality improvement (QI) effort that sought to decrease TTA and assess associated clinical outcomes in pediatric patients with cancer and F&N.Procedure
We used Lean‐Methodology and a Plan‐Do‐Study‐Act approach to direct QI efforts and prospectively tracked TTA measures and associated clinical outcomes (length of stay, duration of fever, use of imaging studies to search for occult infection, bacteremia, intensive care unit (ICU) consultation or admission, and mortality). We then performed statistical analysis to determine the impact of our QI interventions on total TTA, sub‐process times, and clinical outcomes.Results
Our QI interventions significantly improved TTA such that we are now able to deliver antibiotics in <60 min nearly 100% of the time. All TTA sub‐process times also improved. Moreover, achieving TTA <60 min significantly reduced the need for ICU consultation or admission (P = 0.003) in this population.Conclusion
Here we describe our QI effort along with a detailed assessment of several associated clinical outcomes. These data indicate that decreasing TTA to <60 min is achievable and associated with improved outcomes in pediatric patients with cancer and F&N. Pediatr Blood Cancer 2015;62:807–815. © 2015 The Authors. Pediatric Blood & Cancer, published by Wiley Periodicals, Inc. 相似文献67.
Incorporation of resident macrophages in engineered tissues: Multiple cell type response to microenvironment controlled macrophage‐laden gelatine hydrogels
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Camille Dollinger Sait Ciftci Helena Knopf‐Marques Rabia Guner Amir M. Ghaemmaghami Christian Debry Julien Barthes Nihal Engin Vrana 《Journal of tissue engineering and regenerative medicine》2018,12(2):330-340
The success of tissue engineering strategy is strongly related to the inflammatory response, mainly through the activity of macrophages that are key cells in initial immune response to implants. For engineered tissues, the presence of resident macrophages can be beneficial for maintenance of homeostasis and healing. Thus, incorporation of macrophages in engineered tissues can facilitate the integration upon implantation. In this study, an in‐vitro model of interaction was developed between encapsulated naive monocytes, macrophages induced with M1/M2 stimulation and incoming cells for immune assisted tissue engineering applications. To mimic the wound healing cascade, naive THP‐1 monocytes, endothelial cells and fibroblasts were seeded on the gels as incoming cells. The interaction was first monitored in the absence of the gels. To mimic resident macrophages, THP‐1 cells were encapsulated in the presence or absence of IL‐4 to control their phenotype and then these hydrogels were seeded with incoming cells. Without encapsulation, activated macrophages induce apoptosis in endothelial cells. Once encapsulated no adverse effects were seen. Macrophage‐laden hydrogels attracted more endothelial cells and fibroblasts compared to monocytes‐laden hydrogels. The induction (M2 stimulation) of encapsulated macrophages did not change the overall number of attracted cells; but significantly affected their morphology. M1 stimulation by a defined media resulted in more secretion of both pro‐ and anti‐inflammatory cytokines compared to M2 stimulation. It was demonstrated that there is a distinct effect of encapsulated macrophages on the behaviour of the incoming cells; this effect can be harnessed to establish a microenvironment more prone to regeneration upon implantation. 相似文献
68.
Camille Hilliere Daniel Collado-Mateo Santos Villafaina Paulo Duque-Fonseca José A. Parraça 《PM & R》2018,10(10):1062-1072
Objective
To provide an up-to-date research analysis on equine-assisted therapies and horse riding simulation exercise in older adults, and to suggest future directions in clinical practice and research.Type
Systematic review.Literature Survey
A comprehensive search of studies was performed in 4 electronic databases (Cochrane, PubMed, PEDro, and Web of Science) regarding the effects of equine-assisted therapies and horse riding simulation exercise in older adults. Eight articles were selected, 5 of them focused on hippotherapy, 2 on horse riding simulation, and a single article that used the 2 types of therapy.Methodology
PRISMA guidelines were followed for the data extraction process.Synthesis
The studies were all randomized controlled trials, but not double-blind, so they were classified as level of evidence B. Duration of hippotherapy programs ranged from 8-12 weeks. Sessions lasted between 15 and 60 minutes and were performed 2-5 times per week. Interventions using a horse simulator spanned 8 weeks and were conducted for 20 minutes 5 times per week.Conclusions
Results indicate that hippotherapy might improve balance, mobility, gait ability, and muscle strength, as well as could induce hormonal and cerebral activity changes in healthy older adults. Benefits of horse riding simulation could be limited to physical fitness and muscular activity.Level of Evidence
I 相似文献69.
I. Diana Fernandez Nancy P. Chin Carol M. Devine Ann M. Dozier Camille A. Martina Scott McIntosh Kelly Thevenet-Morrison Hongmei Yang 《American journal of public health》2015,105(10):2167-2174
Objectives. We assessed the effects of a worksite multiple-component intervention addressing diet and physical activity on employees’ mean body mass index (BMI) and the percentage of employees who were overweight or obese.Methods. This group-randomized trial (n = 3799) was conducted at 10 worksites in the northeastern United States. Worksites were paired and allocated into intervention and control conditions. Within- and between-groups changes in mean BMIs and in the percentage of overweight or obese employees were examined in a volunteer sample.Results. Within-group mean BMIs decreased by 0.54 kilograms per meter squared (P = .02) and 0.12 kilograms per meter squared (P = .73) at the intervention and control worksites, respectively, resulting in a difference in differences (DID) decrease of 0.42 kilograms per meter squared (P = .33). The within-group percentage of overweight or obese employees decreased by 3.7% (P = .07) at the intervention worksites and increased by 4.9% (P = .1) at the control worksites, resulting in a DID decline of 8.6% (P = .02).Conclusions. Our findings support a worksite population strategy that might eventually reduce the prevalence of overweight and obesity by minimizing environmental exposures to calorically dense foods and increasing exposures to opportunities for energy expenditure within worksite settings.Sixty-eight percent of adults residing in the United States are overweight or obese,1 and these conditions affect more than 1.4 billion adults worldwide.2 Traditional obesity control strategies, which have focused on changing diet and physical activity (PA) behaviors, provide significant individual benefits3 but are considered insufficient to reduce population disease burdens,4,5 for which broad, population-based approaches are needed.6 In addition to individual biology and behaviors, the physical, social, and cultural environment appears to contribute to the upward trend in population estimates of overweight and obesity7,8 by facilitating high-energy, low-nutrient diets and reducing the need to be physically active to perform activities of daily life.9Worksites are feasible self-contained environments with established communication systems in which interventions manipulating the food and PA environment and the social marketing of lifestyle changes can be implemented. Given that 58.4% of the US population aged 16 years or older is employed,10 worksite interventions have the potential to reach large number of adults11 and can foster the participation of employees in project development and sustainability.12–14 Moreover, participatory worksite interventions address workers’ needs, priorities, and interests and allow strategies to be adapted to the realities of individual sites.13 There is also a business case for weight control programs. In comparison with their nonobese counterparts, overweight and obese employees have higher absenteeism rates, have more work limitations, and are less productive.15–18With these issues in mind, the National Heart, Lung, and Blood Institute developed the Obesity Prevention in the Worksite initiative, a population-based approach to promoting behavioral change through environmental interventions that address prevention and control of weight gain.19 Prior to this initiative, worksite trials were either limited scope interventions, targeting a few aspects of the food or PA environment,9,20–23 or broader scope efforts simultaneously targeting risk factors for cardiovascular disease and cancer (e.g., smoking, diet).24–28 In addition, few studies addressed environmental influences related to excessive weight gain.Here we report the results of Images of a Healthy Worksite, one of the studies that is part of the Obesity Prevention in the Worksite initiative; this comprehensive nutrition and PA intervention was designed to promote healthy lifestyles and to stop the shift to the right of the population body mass index (BMI) curve. In this study, worksites were designated to receive an environmental intervention, and employees participated in intervention design. We hypothesized that mean BMIs among employees at the intervention worksites and the percentages of employees who were overweight or obese would not increase over a 2-year period or would increase less than at control worksites. 相似文献
70.
Camille Chatelle Solveig L. Hauger Charlotte Martial Frank Becker Bernd Eifert Dana Boering Joseph T. Giacino Steven Laureys Marianne Løvstad Petra Maurer-Karattup 《Archives of physical medicine and rehabilitation》2018,99(9):1755-1762