全文获取类型
收费全文 | 551460篇 |
免费 | 48786篇 |
国内免费 | 34366篇 |
专业分类
耳鼻咽喉 | 4777篇 |
儿科学 | 6499篇 |
妇产科学 | 8981篇 |
基础医学 | 63153篇 |
口腔科学 | 9995篇 |
临床医学 | 73513篇 |
内科学 | 82412篇 |
皮肤病学 | 6057篇 |
神经病学 | 28987篇 |
特种医学 | 19707篇 |
外国民族医学 | 254篇 |
外科学 | 55893篇 |
综合类 | 89866篇 |
现状与发展 | 106篇 |
一般理论 | 76篇 |
预防医学 | 36724篇 |
眼科学 | 15188篇 |
药学 | 57501篇 |
480篇 | |
中国医学 | 30041篇 |
肿瘤学 | 44402篇 |
出版年
2024年 | 1418篇 |
2023年 | 6806篇 |
2022年 | 18931篇 |
2021年 | 24960篇 |
2020年 | 18787篇 |
2019年 | 16389篇 |
2018年 | 17685篇 |
2017年 | 16231篇 |
2016年 | 14945篇 |
2015年 | 23142篇 |
2014年 | 29212篇 |
2013年 | 27150篇 |
2012年 | 40234篇 |
2011年 | 44362篇 |
2010年 | 28397篇 |
2009年 | 23285篇 |
2008年 | 30336篇 |
2007年 | 30389篇 |
2006年 | 29686篇 |
2005年 | 29243篇 |
2004年 | 19680篇 |
2003年 | 18091篇 |
2002年 | 15473篇 |
2001年 | 13703篇 |
2000年 | 14057篇 |
1999年 | 14303篇 |
1998年 | 8570篇 |
1997年 | 8466篇 |
1996年 | 6623篇 |
1995年 | 6216篇 |
1994年 | 5220篇 |
1993年 | 3431篇 |
1992年 | 4855篇 |
1991年 | 4147篇 |
1990年 | 3468篇 |
1989年 | 2999篇 |
1988年 | 2632篇 |
1987年 | 2317篇 |
1986年 | 1919篇 |
1985年 | 1538篇 |
1984年 | 944篇 |
1983年 | 729篇 |
1982年 | 438篇 |
1981年 | 394篇 |
1980年 | 335篇 |
1979年 | 437篇 |
1978年 | 216篇 |
1977年 | 187篇 |
1974年 | 212篇 |
1973年 | 170篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
42.
内脏利什曼病是全球被忽视的传染病之一,危害严重。而利什曼原虫-人类免疫缺陷病毒(human immunodeficiency virus,HIV)合并感染对流行地区造成的威胁更甚。利什曼原虫与HIV存在相互作用,合并感染者在临床表现、诊断及治疗方面具有一定特殊性,其病死率及复发率均高于HIV阴性的内脏利什曼病患者。本文对利什曼原虫-HIV合并感染患者的临床表现、诊断和治疗进展进行综述。 相似文献
43.
44.
目的:观察非霍奇金淋巴瘤(non-Hodgkin's lymphoma,NHL)患者自体造血干细胞移植(autologous hematopoietic stem cell transplantation,ASCT)术后应用重组人α-2b干扰素(α-2b IFN)进行早期干预治疗的临床疗效。方法:选取18例行ASCT的NHL患者为研究对象,移植前疾病评估均未达到完全缓解(complete remission,CR),试验组血象恢复后给予IFN 3 000 000 U次/隔日干预治疗,3个月后停用;对照组未行干扰素干预治疗,分析总体疗效及两组对比的生存情况。结果:随访中位时间为34(10~50)个月,患者中位生存时间为37(31~45)个月,3年总体无进展生存(progressive free survival,PFS)、总生存(overall survivial,OS)分别为54.7%、66.8%。ASCT后试验组1年内无疾病复发,2年内复发率为12.5%;对照组1年内复发率为20%,2年内复发率为30%。结论:NHL患者在ASCT后给予重组人α-2b IFN早期干预治疗,患者耐受性好,可能降低移植后早期复发率。 相似文献
45.
46.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
47.
48.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
49.
Yang Liu Yanyan Gao Hengliang Liu Qi Chen Jinrui Ji Kailong Jia 《Arquivos brasileiros de cardiologia》2021,116(2):229
BackgroundDual antiplatelet therapy (DAPT) is the cornerstone treatment of acute myocardial infarction (AMI).ObjectiveThe present study aimed to investigate the efficacy and safety of triple antiplatelet therapy (TAPT) in elderly female patients with diabetes and ST segment elevation myocardial infarction (STEMI), who had undergone percutaneous coronary intervention (PCI).MethodsWe designed a randomized, single-blind study. Control group A (97 elderly male patients with diabetes and STEMI, whose CRUSADE scores were < 30) received aspirin, ticagrelor, and tirofiban. A total of 162 elderly female patients with diabetes and STEMI were randomly divided into two groups according to CRUSADE score. Group B (69 patients with CRUSADE score > 31) received aspirin and ticagrelor. Group C (93 patients with CRUSADE score < 30) received aspirin, ticagrelor and tirofiban. P values < 0.05 were considered statistically significant.ResultsCompared to the findings in group A, post-PCI Thrombolysis in Myocardial Infarction (TIMI) grade 3 blood flow and TIMI myocardial perfusion grade 3 were significantly less prevalent in group B (p < 0.05). When compared to groups A and C, the incidence of major adverse complications was significantly higher in group B (p < 0.05).ConclusionTAPT could effectively reduce the incidence of major complications in elderly female patients with diabetes and STEMI. However, close attention should be paid to hemorrhage in patients receiving TAPT. (Arq Bras Cardiol. 2020; [online].ahead print, PP.0-0) 相似文献
50.