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991.
992.
Youdong Kim Gyeong Sik Jeon Sun Young Choi Man Deuk Kim Shin Jae Lee 《Taiwanese journal of obstetrics & gynecology》2017,56(4):477-481
Objective
To evaluate the efficacy and safety of sclerotherapy as the treatment of infected postoperative lymphocele in gynecologic malignancy patients.Materials and methods
Percutaneous catheter drainage (PCD) with or without sclerotherapy was performed for postoperative lymphocele in 75 patients from 2002 to 2014. Eighty-eight lymphoceles (43 non-infected as group A, 45 infected as group B) in 75 patients (mean age ± SD; 50.3 ± 11.3) were included. Sclerotherapy was performed in 17 (39.5%, group A-S) lymphoceles in group A and 14 (31.1%, group B-S) in group B. Absolute ethanol was the most frequently used sclerosant (28 of total 36 sessions). Mean follow-up period was 37 months (range: 1–154).Results
Sclerotherapy was clinically successful in 13 lymphoceles in both group A-S (76.5%) and group B-S (92.9%) without statistical significance. Compared to the pre-sclerotherapy period, group B-S demonstrated significantly decreased drainage volume after sclerotherapy (662.7 ml vs. 100.6 ml, p = 0.019). Group A-S failed to demonstrate significant decrease in drainage volume after sclerotherapy. Recurrence occurred in 4 patients in group A-S and 1 in group B-S, without statistical significance. No major complication was noted.Conclusion
Sclerotherapy significantly reduces the drainage volume, and might help shorten catheter placement time in infected lymphoceles. 相似文献993.
Proteomic analysis of the dorsal spinal cord in the mouse model
of spared nerve injury-induced neuropathic pain
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Eun-sung Park Jung-mo Ahn Sang-min Jeon Hee-jung Cho Ki-myung Chung Je-yoel Cho Dong-ho Youn 《生物医学研究杂志》2017,31(6):494-502
Peripheral nerve injury often causes neuropathic pain and is associated with changes in the expression of numerous
proteins in the dorsal horn of the spinal cord. To date, proteomic analysis method has been used to simultaneously
analyze hundreds or thousands of proteins differentially expressed in the dorsal horn of the spinal cord in rats or
dorsal root ganglion of rats with certain type of peripheral nerve injury. However, a proteomic study using a mouse
model of neuropathic pain could be attempted because of abundant protein database and the availability of transgenic
mice. In this study, whole proteins were extracted from the ipsilateral dorsal half of the 4th–6th lumbar spinal cord in a
mouse model of spared nerve injury (SNI)-induced neuropathic pain. In-gel digests of the proteins size-separated on a
polyacrylamide gel were subjected to reverse-phase liquid-chromatography coupled with electrospray ionization ion
trap tandem mass spectrometry (MS/MS). After identifying proteins, the data were analyzed with subtractive
proteomics using ProtAn, an in-house analytic program. Consequently, 15 downregulated and 35 upregulated
proteins were identified in SNI mice. The identified proteins may contribute to the maintenance of neuropathic pain,
and may provide new or valuable information in the discovery of new therapeutic targets for neuropathic pain. 相似文献
994.
Effects of microalgal polyunsaturated fatty acid oil on body weight and lipid accumulation in the liver of C57BL/6 mice fed a high fat diet
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Ryeo-Eun Go Kyung-A Hwang Geon-Tae Park Hae-Miru Lee Geum-A Lee Cho-Won Kim So-Ye Jeon Jeong-Woo Seo Won-Kyung Hong Kyung-Chul Choi 《生物医学研究杂志》2016,30(3):234-242
Dietary polyunsaturated fatty acids (PUFAs), which are abundant in marine fish oils, have recently received global attention for their prominent anti-obesogenic effects. Among PUFAs, eicosapentaenoic acid (EPA; 20:5n-3) and docosahexaenoic acid (DHA; 22:6n-3), which are n-3 long-chain PUFAs widely referred to as omega-3 oils, were reported to prevent the development of obesity in rodents and humans. In the present study, we evaluated the anti-obesity effects of microalgal oil on high-fat induced obese C57BL/6 mice, compared with commercial omega-3 fish oil and vegetable corn oil. Microalgal oil is an inherent mixture of several PUFAs, including EPA, DHA and other fatty acids produced from a marine microalgal strain of Thraustochytriidae sp. derived mutant. It was found to contain more PUFAs (>80%) and more omega-3 oils than commercial omega-3 fish oil (PUFAs >31%) and corn oil (PUFAs 59%). All three types of oils induced weight loss in high-fat-induced obese mice, with the loss induced by microalgal oil being most significant at 9 weeks (10% reduction). However, the oils tested did not improve blood lipid levels, although microalgal oil showed an apparent inhibitory effect on lipid accumulation in the liver. These findings may be attributed to the higher PUFA content, including omega-3 oils of microalgal oil than other oils. Collectively, these findings suggest that microalgal oil, derived from Thraustochytriidae sp. derived mutant, is a prominent candidate for replacement of omega-3 fish oils based on its apparent anti-obesity effect in vivo. 相似文献
995.
996.
997.
Hepatocyte growth factor‐expressing adenovirus upregulates matrix metalloproteinase‐1 expression in keloid fibroblasts
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998.
999.
High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase. 相似文献
1000.
Hye Jeong Choi Gyeong Sik Jeon Man Deuk Kim Jong Tae Lee Jung Hyun Yoon 《Journal of vascular and interventional radiology : JVIR》2013,24(6):772-778
PurposeTo evaluate the effectiveness, safety, and complications of uterine artery embolization (UAE) in women with large fibroid tumors.Materials and MethodsFrom January 2005 to February 2011, 323 patients underwent UAE for symptomatic uterine leiomyomas without adenomyosis and were included in this study. Patients were divided into two groups: those with a large tumor burden (group 1; n = 63), defined as a dominant tumor with a longest axis of at least 10 cm or a uterine volume of at least 700 cm3; and the control group (group 2; n = 260). Tumor infarction and volume reduction were calculated based on magnetic resonance imaging findings. Symptom status was assessed with a visual analog scale. Postprocedure complications and repeat interventions were recorded. The data were analyzed with appropriate statistical tests.ResultsNo significant differences were seen between the two groups in volume reduction of dominant tumors (46.5% in group 1 vs 52.0% in group 2; P = .082) or percentage volume reduction of the uterus (40.7% in group 1 vs 36.3% in group 2; P = .114). Also, no significant differences were seen between the two groups regarding satisfaction scores at immediate or midterm follow-up (P = .524 and P = .497) or in the presence of procedure-related complications (P = .193).ConclusionsUAE outcomes in large fibroid tumors were comparable to those in smaller tumors, without an increased risk of significant complications. Tumor size may not be a key factor in predicting successful outcomes of UAE. 相似文献