全文获取类型
收费全文 | 1879篇 |
免费 | 249篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 22篇 |
儿科学 | 62篇 |
妇产科学 | 27篇 |
基础医学 | 181篇 |
口腔科学 | 44篇 |
临床医学 | 278篇 |
内科学 | 417篇 |
皮肤病学 | 123篇 |
神经病学 | 119篇 |
特种医学 | 138篇 |
外科学 | 303篇 |
综合类 | 110篇 |
现状与发展 | 30篇 |
一般理论 | 7篇 |
预防医学 | 81篇 |
眼科学 | 15篇 |
药学 | 78篇 |
中国医学 | 3篇 |
肿瘤学 | 108篇 |
出版年
2024年 | 20篇 |
2023年 | 179篇 |
2022年 | 13篇 |
2021年 | 19篇 |
2020年 | 58篇 |
2019年 | 27篇 |
2018年 | 55篇 |
2017年 | 51篇 |
2016年 | 46篇 |
2015年 | 63篇 |
2014年 | 91篇 |
2013年 | 79篇 |
2012年 | 55篇 |
2011年 | 62篇 |
2010年 | 91篇 |
2009年 | 105篇 |
2008年 | 55篇 |
2007年 | 81篇 |
2006年 | 59篇 |
2005年 | 63篇 |
2004年 | 38篇 |
2003年 | 38篇 |
2002年 | 44篇 |
2001年 | 40篇 |
2000年 | 41篇 |
1999年 | 42篇 |
1998年 | 44篇 |
1997年 | 56篇 |
1996年 | 44篇 |
1995年 | 48篇 |
1994年 | 35篇 |
1993年 | 40篇 |
1992年 | 23篇 |
1991年 | 23篇 |
1990年 | 17篇 |
1989年 | 29篇 |
1988年 | 29篇 |
1987年 | 23篇 |
1986年 | 13篇 |
1985年 | 19篇 |
1984年 | 10篇 |
1982年 | 11篇 |
1981年 | 13篇 |
1980年 | 13篇 |
1978年 | 13篇 |
1976年 | 19篇 |
1975年 | 16篇 |
1974年 | 13篇 |
1973年 | 10篇 |
1945年 | 9篇 |
排序方式: 共有2146条查询结果,搜索用时 15 毫秒
21.
Effects of Enteral Nutrition on the Barrier Function of the Intestinal Mucosa and Dopamine Receptor Expression in Rats With Traumatic Brain Injury 下载免费PDF全文
Background: Impaired intestinal mucosal barrier (IMB) function is common in traumatic brain injury (TBI), but dopamine receptors (DRs) change in intestinal mucosa after TBI, and effects of enteral nutrition (EN) and supplements on IMB function remain unclear. Our purpose was to study the effects of EN and supplements on intestinal mucosal permeability (IMPB) and the expression of DRs DRD1 and DRD2 in the intestinal mucosa of rats with TBI. Methods: Forty‐eight rats were divided into 8 groups; control, animals with TBI, dopamine group, animals with TBI treated with dopamine antagonist, EN alone, or EN combined with glutamine, probiotics, or a combination of probiotics and glutamine daily after TBI. Results: The IMPB was improved in the glutamine, probiotics, and combination groups. Including probiotics improved IMPB more than adding glutamine, and bacterial translocation in the intestines after TBI was reduced in the probiotics and combination groups (all Ps < .01). TBI led to elevated DRD1 and DRD2 mRNA and protein levels, which were reduced in the DA antagonist, glutamine, probiotics, and combination groups. DRD2 mRNA and protein levels in the probiotics and combination groups were decreased more than in the DA antagonist group (all Ps < .01). The increased IMPB after TBI correlated with increased DRD1 and DRD2 levels in the rat intestinal mucosa. Conclusion: EN supplemented with probiotics or combining glutamine and probiotics lowers the increased IMPB, bacterial translocation, and DRD1 and DRD2 mRNA and protein expression in rat intestinal mucosa caused by TBI. 相似文献
22.
GCH1 attenuates cardiac autonomic nervous remodeling in canines with atrial‐tachypacing via tetrahydrobiopterin pathway regulated by microRNA‐206 下载免费PDF全文
23.
James W Murrough Katherine E Burdick Cara F Levitch Andrew M Perez Jess W Brallier Lee C Chang Alexandra Foulkes Dennis S Charney Sanjay J Mathew Dan V Iosifescu 《Neuropsychopharmacology》2015,40(5):1084-1090
The glutamate N-methyl-D-aspartate (NMDA) receptor antagonist ketamine displays rapid antidepressant effects in patients with treatment-resistant depression (TRD); however, the potential for adverse neurocognitive effects in this population has not received adequate study. The current study was designed to investigate the delayed neurocognitive impact of ketamine in TRD and examine baseline antidepressant response predictors in the context of a randomized controlled trial. In the current study, 62 patients (mean age=46.2±12.2) with TRD free of concomitant antidepressant medication underwent neurocognitive assessments using components of the MATRICS Consensus Cognitive Battery (MCCB) before and after a single intravenous infusion of ketamine (0.5 mg/kg) or midazolam (0.045 mg/kg). Participants were randomized to ketamine or midazolam in a 2:1 fashion under double-blind conditions and underwent depression symptom assessments at 24, 48, 72 h, and 7 days post treatment using the Montgomery–Asberg Depression Rating Scale (MADRS). Post-treatment neurocognitive assessment was conducted once at 7 days. Neurocognitive performance improved following the treatment regardless of treatment condition. There was no differential effect of treatment on neurocognitive performance and no association with antidepressant response. Slower processing speed at baseline uniquely predicted greater improvement in depression at 24 h following ketamine (t=2.3, p=0.027), while controlling for age, depression severity, and performance on other neurocognitive domains. In the current study, we found that ketamine was devoid of adverse neurocognitive effects at 7 days post treatment and that slower baseline processing speed was associated with greater antidepressant response. Future studies are required to further define the neurocognitive profile of ketamine in clinical samples and to identify clinically useful response moderators. 相似文献
24.
The model of the clinical practice of emergency medicine 总被引:13,自引:0,他引:13
Hockberger RS Binder LS Graber MA Hoffman GL Perina DG Schneider SM Sklar DP Strauss RW Viravec DR Koenig WJ Augustine JJ Burdick WP Henderson WV Lawrence LL Levy DB McCall J Parnell MA Shoji KT;American College of Emergency Physicians Core Content Task Force II 《Annals of emergency medicine》2001,37(6):745-770
25.
Background
The clinical phenotype of bipolar disorder (BPD) is heterogeneous and the genetic architecture of the disorder is complex and not well understood. Given these complications, it is possible that the identification of intermediate phenotypes (“endophenotypes”) will be useful in elucidating the complex genetic mechanisms that result in the disorder. The examination of unaffected relatives is critical in determining whether a particular trait is genetically-relevant to BPD. However, few dimensional traits related to BPD have been assessed in unaffected relatives of patients.Methods
We assessed affective temperament and schizotypy in 55 discordant sibling pairs and 113 healthy controls (HCs) using the Temperament Evaluation of Memphis, Pisa, Paris, and San Diego, Auto-questionnaire version (TEMPS-A) to assess affective temperament and the Schizotypal Personality Questionnaire (SPQ) to assess schizotypy.Results
BPD patients scored significantly higher than HCs on all subscales of the SPQ and on all but one subscale (hyperthymic) of the TEMPS-A (all p<0.01). Siblings demonstrated scores that were significantly intermediate to patients and HCs on the anxious subscale of the TEMPS-A and on the interpersonal deficits and disorganized subscales of the SPQ.Limitations
We did not investigate the BPD spectrum as most patients were diagnosed with BPD I (n=47). Most of the patients had experienced psychosis (n=42) and so we were unable to examine whether psychosis status impacted upon affective temperament or schizotypy in patients or their siblings.Conclusion
These data suggest that schizotypy and affective temperament represent dimensional traits that are likely to underlie the genetic risk for BPD. 相似文献26.
Surgical management of early and late ureteral complications after renal transplantation: techniques and outcomes 下载免费PDF全文
27.
28.
29.
30.