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81.
82.
Emotion recognition impairment is present early and is stable throughout the course of schizophrenia
Anna Comparelli Valentina Corigliano Antonella De Carolis Iginia Mancinelli Giada Trovini Giorgia Ottavi Julia Dehning Roberto Tatarelli Roberto Brugnoli Paolo Girardi 《Schizophrenia Research》2013,143(1):65-69
Individuals with schizophrenia experience problems in the perception of emotion throughout the course of the disorder. Few studies have addressed the progression of the deficit over time. The present investigation explores face emotion recognition (FER) performance throughout the course of schizophrenia. The aim of the study was to test the hypotheses that: 1) FER impairment was present in ultra high-risk (putatively prodromal) individuals, and that 2) impairment was stable across the course of the illness. Forty-three individuals with a putative prodromal syndrome, 50 patients with first episode of schizophrenia, 44 patients with multi-episode schizophrenia and 86 unaffected healthy control subjects were assessed to examine emotion recognition ability. ANCOVA analysis adjusted for possible confounder factors and subsequent planned contrasts with healthy controls was undertaken. The results revealed deficits in recognition of sadness and disgust in prodromal individuals, and of all negative emotions in both first-episode and multi-episode patients. Furthermore, there were no significant differences between clinical groups. Within the framework of the neurodevelopmental model of schizophrenia, our results suggest the presence of emotional recognition impairment before the onset of full-blown psychosis. Moreover, the deficit remains stable over the course of illness, fitting the pattern of a vulnerability indicator in contrast to an indicator of chronicity or severity. 相似文献
83.
Bruna R. Zancopé Lívia P. Rodrigues Thais M. Parisotto Carolina Steiner-Oliveira Lidiany K. A. Rodrigues Marinês Nobre-dos-Santos 《Lasers in medical science》2016,31(3):539-547
This study evaluated if Carbon dioxide (CO2) (λ 10.6 μm) laser irradiation combined with acidulated phosphate fluoride gel application (APF gel) enhances “CaF2” uptake by demineralized enamel specimens (DES) and inhibits enamel lesion progression. Thus, two studies were conducted and DES were subjected to APF gel combined or not with CO2 laser irradiation (11.3 or 20.0 J/cm2, 0.4 or 0.7 W) performed before, during, or after APF gel application. In study 1, 165 DES were allocated to 11 groups. Fluoride as “CaF2 like material” formed on enamel was determined in 100 DES (n?=?10/group), and the surface morphologies of 50 specimens were evaluated by scanning electron microscopy (SEM) before and after “CaF2” extraction. In study 2, 165 DES (11 groups, n?=?15), subjected to the same treatments as in study 1, were further subjected to a pH-cycling model to simulate a high cariogenic challenge. The progression of demineralization in DES was evaluated by cross-sectional microhardness and polarized light microscopy analyses. Laser at 11.3 J/cm2 applied during APF gel application increased “CaF2” uptake on enamel surface. Laser irradiation and APF gel alone arrested the lesion progression compared with the control (p?<?0.05). Areas of melting, fusion, and cracks were observed. CO2 laser irradiation, combined with a single APF application enhanced “CaF2” uptake on enamel surface and a synergistic effect was found. However, regarding the inhibition of caries lesion progression, no synergistic effect could be demonstrated. In conclusion, the results have shown that irradiation with specific laser parameters significantly enhanced CaF2 uptake by demineralized enamel and inhibited lesion progression. 相似文献
84.
85.
Juliana Damasceno Oliveira Lígia Nunes de Morais Ribeiro Gustavo Henrique Rodrigues da Silva Bruna Renata Casadei Verônica Muniz Couto Elizabeth Ferreira Martinez Eneida de Paula 《Pharmaceutical research》2018,35(12):229
Purpose
Etidocaine (EDC) is a long lasting local anesthetic, which alleged toxicity has restricted its clinical use. Liposomes can prolong the analgesia time and reduce the toxicity of local anesthetics. Ionic gradient liposomes (IGL) have been proposed to increase the upload and prolong the drug release, from liposomes.Methods
First, a HPLC method for EDC quantification was validated. Then, large unilamellar vesicles composed of hydrogenated soy phosphatidylcholine:cholesterol with 250 mM (NH4)2SO4 - inside gradient - were prepared for the encapsulation of 0.5% EDC. Dynamic light scattering, nanotracking analysis, transmission electron microscopy and electron paramagnetic resonance were used to characterize: nanoparticles size, polydispersity, zeta potential, concentration, morphology and membrane fluidity. Release kinetics and in vitro cytotoxicity tests were also performed.Results
IGLEDC showed average diameters of 172.3?±?2.6 nm, low PDI (0.12?±?0.01), mean particle concentration of 6.3?±?0.5?×?1012/mL and negative zeta values (?10.2?±?0.4 mV); parameters that remain stable during storage at 4°C. The formulation, with 40% encapsulation efficiency, induced the sustained release of EDC (ca. 24 h), while reducing its toxicity to human fibroblasts.Conclusion
A novel formulation is proposed for etidocaine that promotes sustained release and reduces its cytotoxicity. IGLEDC can come to be a tool to reintroduce etidocaine in clinical use.86.
87.
In this study, we examined the factors contributing to quality of life (QOL) of older adults in regions of Canada and Brazil. The WHOQOL-BREF and a demographic data sheet were administered to random samples of 202 older adults from Canada and 288 from Brazil. Ratings on overall QOL and on the physical, psychological, and environmental domains were higher in the Canadian sample. Social domain scores were not significantly different. The authors found the same pattern of factors (health satisfaction, enough money, meaning in life, and opportunities for leisure activities) contributed to the variance of QOL in both countries, except for physical environment, which was significant in Brazil and not in Canada. Health satisfaction was the strongest contributor to QOL in both samples, and satisfaction with personal relationships was not significant in either country. 相似文献
88.
Alvarenga Livia Cardozo Ludmila F. M. F. Da Cruz Beatriz O. Paiva Bruna R. Fouque Denis Mafra Denise 《International urology and nephrology》2022,54(10):2645-2652
International Urology and Nephrology - Recent studies have shed light on the potential role of curcumin in mitigating inflammation in patients with chronic kidney disease (CKD). This study aimed to... 相似文献
89.
Soffin Ellen M. Beckman James D. Beathe Jonathan C. Girardi Federico P. Liguori Gregory A. Liu Jiabin 《HSS journal》2020,16(1):72-80
HSS Journal ® - Laminectomy is commonly used in the treatment of lumbar spine pathology. Laminectomies are increasingly being performed in outpatient settings, but patient safety concerns... 相似文献