全文获取类型
收费全文 | 502篇 |
免费 | 27篇 |
国内免费 | 5篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 21篇 |
妇产科学 | 11篇 |
基础医学 | 42篇 |
口腔科学 | 6篇 |
临床医学 | 33篇 |
内科学 | 89篇 |
皮肤病学 | 8篇 |
神经病学 | 16篇 |
特种医学 | 82篇 |
外科学 | 102篇 |
综合类 | 42篇 |
预防医学 | 19篇 |
眼科学 | 6篇 |
药学 | 21篇 |
肿瘤学 | 35篇 |
出版年
2021年 | 9篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 17篇 |
2017年 | 6篇 |
2016年 | 6篇 |
2015年 | 8篇 |
2014年 | 10篇 |
2013年 | 20篇 |
2012年 | 7篇 |
2011年 | 12篇 |
2010年 | 26篇 |
2009年 | 28篇 |
2008年 | 11篇 |
2007年 | 15篇 |
2006年 | 34篇 |
2005年 | 20篇 |
2004年 | 43篇 |
2003年 | 18篇 |
2002年 | 12篇 |
2001年 | 7篇 |
2000年 | 6篇 |
1999年 | 3篇 |
1998年 | 25篇 |
1997年 | 22篇 |
1996年 | 21篇 |
1995年 | 28篇 |
1994年 | 17篇 |
1993年 | 7篇 |
1992年 | 6篇 |
1991年 | 3篇 |
1990年 | 4篇 |
1989年 | 13篇 |
1988年 | 10篇 |
1987年 | 7篇 |
1986年 | 9篇 |
1985年 | 2篇 |
1984年 | 5篇 |
1983年 | 7篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1980年 | 6篇 |
1978年 | 4篇 |
1977年 | 4篇 |
排序方式: 共有534条查询结果,搜索用时 0 毫秒
91.
92.
Andersson HC Narumanchi TC Cunningham A Bowdish B Thoene J 《Molecular genetics and metabolism》2006,88(1):3-6
Provision of health care to patients during and after events like those which occurred in association with hurricanes Katrina and Rita poses particular difficulties for rare disease patients, including those with genetic/metabolic diseases. In this summary, we recount the obstacles encountered in attempting to maintain and restore essential medical care to these patients, and offer proposals which may mitigate future such events. 相似文献
93.
94.
95.
Allison E. Kennedy Laura Cook Jessica A. Breznik Braeden Cowbrough Jessica G. Wallace Angela Huynh James W. Smith Kiho Son Hannah Stacey Jann Ang Allison McGeer Brenda L. Coleman Maggie Larch Mark Larch Nathan Hambly Parameswaran Nair Kjetil Ask Matthew S. Miller Jonathan Bramson Megan K. Levings Ishac Nazy Sarah Svenningsen Manali Mukherjee Dawn M. E. Bowdish 《Viruses》2021,13(11)
Survivors of severe SARS-CoV-2 infections frequently suffer from a range of post-infection sequelae. Whether survivors of mild or asymptomatic infections can expect any long-term health consequences is not yet known. Herein we investigated lasting changes to soluble inflammatory factors and cellular immune phenotype and function in individuals who had recovered from mild SARS-CoV-2 infections (n = 22), compared to those that had recovered from other mild respiratory infections (n = 11). Individuals who had experienced mild SARS-CoV-2 infections had elevated levels of C-reactive protein 1–3 months after symptom onset, and changes in phenotype and function of circulating T-cells that were not apparent in individuals 6–9 months post-symptom onset. Markers of monocyte activation, and expression of adherence and chemokine receptors indicative of altered migratory capacity, were also higher at 1–3 months post-infection in individuals who had mild SARS-CoV-2, but these were no longer elevated by 6–9 months post-infection. Perhaps most surprisingly, significantly more T-cells could be activated by polyclonal stimulation in individuals who had recently experienced a mild SARS-CoV-2, infection compared to individuals with other recent respiratory infections. These data are indicative of prolonged immune activation and systemic inflammation that persists for at least three months after mild or asymptomatic SARS-CoV-2 infections. 相似文献
96.
Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not glutathione deficient cells 总被引:7,自引:5,他引:7
Cell to cell communication via gap junctions is essential in the
maintenance of the homeostatic balance of multicellular organisms. Aberrant
intercellular gap junctional communication (GJIC) has been implicated in
tumor promotion, neuropathy and teratogenesis. Oxidative stress has also
been implicated in similar pathologies such as cancer. We report a
potential link between oxidative stress and GJIC. Hydrogen peroxide, a
known tumor promoter, inhibited GJIC in WB-F344 rat liver epithelial cells
with an I50 value of 200 microM. Inhibition of GJIC by H2O2 was reversible
as indicated by the complete recovery of GJIC with the removal of H2O2 via
a change of fresh media. Free radical scavengers, such as t-butyl alcohol,
propylgallate, and Trolox, did not prevent the inhibition of GJIC by H2O2,
which indicated that the effects of H2O2 on GJIC was probably not a
consequence of aqueous free radical damage. The depletion of intracellular
GSH reversed the inhibitory effect of H2O2 on GJIC. The treatment of
glutathione- sufficient cells with H2O2 resulted in the
hyperphosphorylation of connexin43, which is the basic subunit of the
hexameric gap junction protein, as determined by Western blot analysis.
TPA, a well-known tumor promoter, also inhibits GJIC via
hyperphosphorylation of GJIC, which is a result of protein kinase-C
activation. However, H2O2 also induced hyperphosphorylation in
GSH-deficient cells that had normal rates of GJIC. Therefore, the mechanism
of GJIC inhibition must be different from the TPA-pathway and involves GSH.
相似文献
97.
WFC Van Gelderen M Al-Hindawi CG Archibald AEH Merrie KS Cheng 《Journal of Medical Imaging and Radiation Oncology》1995,39(4):408-410
A dermold cyst, arising from the posterior aspects of the prostate and seminal vesicles, and extending into the pelvis to masquerade as a full bladder, must be exceedingly rare. Ultrasound, computed tomography and especially magnetic resonance imaging (MRI) proved to be invaluable in making the diagnosis, and MRI in particular was very useful in providing an anatomical road map for surgery. 相似文献
98.
99.
100.
KS Oppegaard M Lieng A Berg O Istre E Qvigstad B-I Nesheim 《BJOG : an international journal of obstetrics and gynaecology》2010,117(1):53-61
Objective To compare the impact of 1000 μg of self-administered vaginal misoprostol versus self-administered vaginal placebo on preoperative cervical ripening after 2 weeks of pretreatment with estradiol vaginal tablets in postmenopausal women prior to day-care operative hysteroscopy.
Design Randomised, double-blind, placebo-controlled sequential trial.
Setting Norwegian university teaching hospital.
Population Sixty-seven postmenopausal women referred for day-care operative hysteroscopy.
Methods The women were randomised to receive either 1000 μg of self-administered vaginal misoprostol or self-administered vaginal placebo on the evening before day-care operative hysteroscopy. All women had administered a 25-μg vaginal estradiol tablet daily for 14 days prior to the operation.
Main outcome measures Primary outcome: preoperative cervical dilatation at hysteroscopy. Secondary outcomes: difference in dilatation at recruitment and before hysteroscopy, number of women who achieved a preoperative cervical dilatation of 5 mm or more, acceptability, complications and adverse effects.
Results The mean cervical dilatation was 5.7 mm (SD, 1.6 mm) in the misoprostol group and 4.7 mm (SD, 1.5 mm) in the placebo group, the mean difference in cervical dilatation being 1.0 mm (95% CI, 0.2–1.7 mm). Self-administered vaginal misoprostol of 1000 μg at home on the evening before day-care hysteroscopy is safe and highly acceptable, although a small proportion of women experienced lower abdominal pain.
Conclusions One thousand micrograms of self-administered vaginal misoprostol, 12 hours prior to day-care hysteroscopy, after 14 days of pretreatment with vaginal estradiol, has a significant cervical ripening effect compared with placebo in postmenopausal women. 相似文献
Design Randomised, double-blind, placebo-controlled sequential trial.
Setting Norwegian university teaching hospital.
Population Sixty-seven postmenopausal women referred for day-care operative hysteroscopy.
Methods The women were randomised to receive either 1000 μg of self-administered vaginal misoprostol or self-administered vaginal placebo on the evening before day-care operative hysteroscopy. All women had administered a 25-μg vaginal estradiol tablet daily for 14 days prior to the operation.
Main outcome measures Primary outcome: preoperative cervical dilatation at hysteroscopy. Secondary outcomes: difference in dilatation at recruitment and before hysteroscopy, number of women who achieved a preoperative cervical dilatation of 5 mm or more, acceptability, complications and adverse effects.
Results The mean cervical dilatation was 5.7 mm (SD, 1.6 mm) in the misoprostol group and 4.7 mm (SD, 1.5 mm) in the placebo group, the mean difference in cervical dilatation being 1.0 mm (95% CI, 0.2–1.7 mm). Self-administered vaginal misoprostol of 1000 μg at home on the evening before day-care hysteroscopy is safe and highly acceptable, although a small proportion of women experienced lower abdominal pain.
Conclusions One thousand micrograms of self-administered vaginal misoprostol, 12 hours prior to day-care hysteroscopy, after 14 days of pretreatment with vaginal estradiol, has a significant cervical ripening effect compared with placebo in postmenopausal women. 相似文献