全文获取类型
收费全文 | 149篇 |
免费 | 13篇 |
国内免费 | 8篇 |
专业分类
基础医学 | 30篇 |
口腔科学 | 1篇 |
临床医学 | 21篇 |
内科学 | 31篇 |
皮肤病学 | 11篇 |
神经病学 | 1篇 |
特种医学 | 3篇 |
外科学 | 11篇 |
综合类 | 1篇 |
预防医学 | 8篇 |
眼科学 | 3篇 |
药学 | 27篇 |
肿瘤学 | 22篇 |
出版年
2023年 | 1篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 2篇 |
2014年 | 2篇 |
2013年 | 5篇 |
2012年 | 6篇 |
2011年 | 10篇 |
2010年 | 8篇 |
2009年 | 2篇 |
2008年 | 11篇 |
2007年 | 14篇 |
2006年 | 10篇 |
2005年 | 5篇 |
2004年 | 3篇 |
2003年 | 9篇 |
2002年 | 1篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 5篇 |
1998年 | 3篇 |
1997年 | 3篇 |
1996年 | 3篇 |
1995年 | 3篇 |
1993年 | 5篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 3篇 |
1988年 | 9篇 |
1987年 | 1篇 |
1986年 | 2篇 |
1984年 | 1篇 |
1983年 | 1篇 |
1982年 | 2篇 |
1965年 | 1篇 |
1926年 | 2篇 |
排序方式: 共有170条查询结果,搜索用时 0 毫秒
61.
62.
T L Borok J S Cooper 《International journal of radiation oncology, biology, physics》1982,8(8):1449-1451
To improve our understanding of hyperamylasemia secondary to parotid gland irradiation, serial serum amylase levels were measured from 12 consecutive patients who received incidental parotid irradiation during radiotherapy of their head and neck tumors. Rapid transient increases in enzyme activity, limited to the first days of radiotherapy, were consistently found. Awareness of the frequency and nature of this response may avoid unnecessary investigation and concern for abdominal pathology in this clinical setting. 相似文献
63.
Experimental avian cryptococcosis 总被引:2,自引:0,他引:2
64.
Successful establishment of long-term bone marrow cultures in 103 patients with myelodysplastic syndromes 总被引:5,自引:0,他引:5
Alvi S Shaher A Shetty V Henderson B Dangerfield B Zorat F Joshi L Anthwal S Lisak L Little L Gezer S Mundle S Reddy PL Allampallam K Huang X Galili N Borok RZ Raza A 《Leukemia research》2001,25(11):941-954
We used bone marrow biopsies instead of mononuclear cells to maintain long-term cultures from 103 patients belonging to all five sub-categories of myelodysplastic syndromes (MDS), as well as 12 normal controls. By week 4, 30-50% confluency was reached and could be maintained for up to 12 weeks with 100% confluency. The four prominent cells were fibroblasts, macrophages, endothelial cells and adipocytes. Immunohistochemical and electron microscopic studies provided lineage confirmation. Normal hematopoiesis was well supported by MDS stroma. Neither the FAB nor cytogenetics was co-related with the potency of growth. MDS stroma appears to be both morphologically and functionally normal. 相似文献
65.
Liu RM Borok Z Forman HJ 《American journal of respiratory cell and molecular biology》2001,24(4):499-505
Previous studies from this laboratory demonstrated that 4-hydroxy-2-nonenal (4HNE), a lipid peroxidation product, induces expression of gamma-glutamylcysteine synthetase (GCS), the rate-limiting enzyme in de novo glutathione (GSH) synthesis, in rat alveolar epithelial L2 cells. The present study demonstrates that 4HNE also induces GCS in primary cultured alveolar epithelial type II (AT2) cells. Enzyme activity, protein content, and messenger RNA levels of both the catalytic (GCS-HS) and regulatory (GCS-LS) subunits were significantly increased in AT2 cells treated with 5 or 10 microM 4HNE, the same concentrations that induced GCS expression in L2 cells. As in L2 cells, 4HNE induced a greater AT2-cell increase in GCS-LS than in GCS-HS, suggesting that modulation of GCS-LS may play a dominant role in regulating GSH concentration in response to oxidative stress. Additional studies using mitogen-activated protein kinase pathway inhibitors showed that induction by 4HNE of GCS-HS, but not GCS-LS, was mediated through activation of the extracellular regulated kinase pathway in L2 cells. The results demonstrate that L2 cells maintain the same responsiveness to oxidant challenge as do primary cultured AT2 cells in terms of increasing GSH synthetic capacity, and that different pathways are involved in the induction of two GCS subunits by 4HNE. 相似文献
66.
Jenkins G Blanchard A Borok Z Bradding P Ehrhardt C Fisher A Hirani N Johnson S Königshoff M Maher TM Millar A Parfrey H Scotton C Tetley T Thickett D Wolters P;ECIPF workshop 《Thorax》2012,67(2):179-182
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown aetiology. It has a very poor prognosis and no effective treatment. There are two major barriers to the development of novel treatments in IPF: an incomplete understanding of its pathogenesis and the fact that current models of the disease are poorly predictive of therapeutic response. Recent studies suggest an important role for the alveolar epithelium in the pathogenesis of IPF. However, practical limitations associated with isolation and culture of primary alveolar epithelial cells have hampered progress towards further elucidating their role in the pathogenesis of the disease or developing disease models that accurately reflect the epithelial contribution. The practical limitations of primary alveolar epithelial cell culture can be divided into technical, logistical and regulatory hurdles that need to be overcome to ensure rapid progress towards improved treatment for patients with IPF. To develop a strategy to facilitate alveolar epithelial cell harvest, retrieval and sharing between IPF research groups and to determine how these cells contribute to IPF, a workshop was organised to discuss the central issues surrounding epithelial cells in IPF (ECIPF). The central themes discussed in the workshop have been compiled as the proceedings of the ECIPF. 相似文献
67.
目的:考察甲壳胺对不同性质药物的适应性。方法:选择了盐酸麻黄碱,盐酸心得安,卡马西平,磺胺嘧啶,阿司匹林,法莫替丁,朴热息痛,潘生丁,茶碱,炎痛喜康,水杨酸等不同性质的11种药物,以甲胺为阻滞剂,制备了缓释型骨架片溶出效果。结果:甲壳胺的缓释作用随药物碱性增强,分子量增大,溶解度降低而增强,结论:甲 胺对不同性质的药物均有一定缓释作用。 相似文献
68.
69.
70.
Jain R Shaul PW Borok Z Willis BC 《American journal of respiratory cell and molecular biology》2007,37(1):38-47
Endothelin-1 (ET-1) is implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF), but the cellular mechanisms underlying the role it plays in this disease are not well characterized. Epithelial-mesenchymal transition (EMT), which was recently demonstrated in alveolar epithelial cells (AEC), may play an important role in the pathogenesis of IPF and other forms of pulmonary fibrosis. Whether ET-1 contributes to the induction of EMT in AEC is unknown. The aims of this study were to evaluate AEC production of ET-1 and to determine if ET-1 induces EMT in AEC. We demonstrate that ET-1 is produced at physiologically relevant levels by primary AEC and is secreted preferentially toward the basolateral surface. We also demonstrate that AEC express high levels of endothelin type A receptors (ET-A) and, to a lesser extent, type B receptors (ET-B), suggesting autocrine or paracrine function for alveolar ET-1. In addition, ET-1 induces EMT through ET-A activation. Furthermore, TGF-beta1 synthesis is increased by ET-1, ET-1 induces Smad3 phosphorylation, and ET-1-induced EMT is attenuated by a TGF-beta1-neutralizing antibody. Thus, ET-1 is an important mediator of EMT in AEC, acting through ET-A-mediated TGF-beta1 production. These findings increase our basic understanding of the role of ET-1 in pulmonary fibrosis and suggest potential roles for AEC-derived ET-1 in the pathogenesis of other alveolar epithelial-mediated lung diseases. 相似文献