全文获取类型
收费全文 | 1476篇 |
免费 | 187篇 |
国内免费 | 75篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 23篇 |
妇产科学 | 9篇 |
基础医学 | 169篇 |
口腔科学 | 43篇 |
临床医学 | 222篇 |
内科学 | 354篇 |
皮肤病学 | 48篇 |
神经病学 | 83篇 |
特种医学 | 112篇 |
外科学 | 122篇 |
综合类 | 89篇 |
预防医学 | 112篇 |
眼科学 | 8篇 |
药学 | 166篇 |
中国医学 | 1篇 |
肿瘤学 | 172篇 |
出版年
2021年 | 18篇 |
2020年 | 9篇 |
2019年 | 19篇 |
2018年 | 23篇 |
2017年 | 19篇 |
2016年 | 27篇 |
2015年 | 20篇 |
2014年 | 24篇 |
2013年 | 61篇 |
2012年 | 64篇 |
2011年 | 59篇 |
2010年 | 56篇 |
2009年 | 50篇 |
2008年 | 41篇 |
2007年 | 106篇 |
2006年 | 70篇 |
2005年 | 60篇 |
2004年 | 57篇 |
2003年 | 54篇 |
2002年 | 56篇 |
2001年 | 48篇 |
2000年 | 58篇 |
1999年 | 43篇 |
1998年 | 32篇 |
1997年 | 36篇 |
1996年 | 35篇 |
1995年 | 37篇 |
1994年 | 15篇 |
1993年 | 29篇 |
1992年 | 29篇 |
1991年 | 30篇 |
1990年 | 25篇 |
1989年 | 38篇 |
1988年 | 27篇 |
1987年 | 28篇 |
1986年 | 30篇 |
1985年 | 31篇 |
1984年 | 15篇 |
1983年 | 23篇 |
1982年 | 21篇 |
1981年 | 15篇 |
1980年 | 14篇 |
1979年 | 10篇 |
1978年 | 17篇 |
1977年 | 11篇 |
1976年 | 12篇 |
1975年 | 19篇 |
1974年 | 11篇 |
1973年 | 9篇 |
1971年 | 8篇 |
排序方式: 共有1738条查询结果,搜索用时 731 毫秒
91.
Following transection of peripheral nerve, rats exhibit autotomy, which is considered to be the animal model of postdenervation pain syndrome. It has been suggested that phantom limb pain is a result of peripheral denervation leading to reorganization of somatosensory pathways, particularly in the cerebral cortex, which is shown to depend upon central noradrenergic activity. In this study, sciatic and saphenous nerves were sectioned in the left hindpaw of 30 adult rats resulting in complete loss of pain sensation in the hindpaw. A group of rats received normal saline, compared to another group which received N-(2-) Chloroethyl-N-ethyl-2-bromobenzylamine (DSP4) injection 24 h prior to transection. The latter group was also compared to a third group whose central noradrenergic system were also blocked by bilateral injection of 6-OHDA into the ascending noradrenergic bundle 1 week prior to transection. A fourth group received contralateral cortical ablation in addition to peripheral nerve transection and was compared to the first group whose cortex remained intact. The animals were observed daily for 60 days and autotomy was scored in accordance to the system of Wall et al. After 1 week, control animals began to exhibit autotomy. In contrast, autotomy was absent in rats treated with DSP4, similar to rats which received 6-OHDA. Rats which had contralateral cortical ablation showed a considerably delayed onset of autotomy and a reduction in final autotomy scores. We conclude that autotomy, as a model of postdenervation pain syndrome, can be prevented by blockade of noradrenergically mediated cortical reorganization. The clinical implications of this finding are discussed. 相似文献
92.
93.
Schild SE Stella PJ Geyer SM Bonner JA Marks RS McGinnis WL Goetz SP Kuross SA Mailliard JA Kugler JW Schaefer PL Jett JR 《International journal of radiation oncology, biology, physics》2002,54(2):370-378
PURPOSE: This Phase III study was performed to determine whether chemotherapy plus b.i.d. or q.d. radiotherapy (RT) resulted in superior survival for patients with Stage III non-small-cell lung cancer (NSCLC). METHODS AND MATERIALS: Patients with Stage III NSCLC and an Eastern Cooperative Oncology Group performance status of 相似文献
94.
95.
Mucormycosis is a rare fungal infection of childhood, occurring mainly in
patients with chronic illnesses such as diabetes and malignancies. The
fungus seldom grows in culture and confirmation of the diagnosis depends on
histologic examination of infected tissues. To date, the reported natural
history of the disease has been rapid progression and a fatal outcome.
Therefore, the importance of early diagnosis by tissue biopsy and early
treatment with surgical debridement and systemic antifungal therapy cannot
be overemphasized. The pulmonary system is the most common site for
mucormycosis in patients with leukemia. We report what we believe to be the
first successfully treated case of isolated muscular mucormycosis occurring
in a child with biphenotypic acute leukemia. The diagnosis was made
promptly by tissue examination at the time of surgical debridement. The
patient was also given systemic amphotericin-B therapy.
相似文献
96.
97.
The distribution of altered G-actin was investigated in prostatic cells obtained by fine needle aspiration (FNA) from 27 excised prostate glands obtained during radical prostatectomy. FNA, which was used to obtain single cells for image analysis, sampled in the region of any nodules and in grossly normal areas of the contralateral lobes. Quantitative fluorescence-image analysis was used to assay the amount of G-actin in individual cells. Abnormal G-actin, a precursor cytoskeletal protein representing cytoskeletal rearrangements accompanying cellular transformation, was associated with the presence of adenocarcinoma in 22 of 27 specimens from the dominant nodule, but only 3 of 20 in the grossly normal specimens (P<.0001). The mean G-actin content of all samples from the dominant nodule was 113.2+/-6.87 and 69.57+/-4.47 from the grossly normal area, the difference being significant at P<.0001. Altered G-actin was not associated with Gleason score (P = .95), grade (P = .26), stage (P = .058), or tumor volume (P = .32), thereby indicating it is a general marker for prostate adenocarcinoma. 相似文献
98.
Childs HA Spencer SA Raben D Bonner JA Newsome J Robert F 《International journal of radiation oncology, biology, physics》2000,47(4):939-944
PURPOSE: This Phase I study combines tegafur and uracil (UFT) with leucovorin and conventional radiation for the treatment of pancreatic cancer. The design seeks to determine the maximum tolerated dose (MTD) and dose-limiting toxicities (DLT) of this regimen as well as to define a future Phase II dose level. METHODS: Patients with locally advanced and unresectable pancreatic cancer were treated with 45 Gy of radiation therapy. The initial UFT dose was 150 mg/m(2)/day given with leucovorin 90 mg/day, both divided into 3 daily doses for 35 days concurrent with radiation. UFT doses were escalated at increments of 50 mg/m(2)/day. Dose-limiting toxicity (DLT) was defined as Grade 3 or greater nausea, vomiting or diarrhea despite medical intervention; or Grade 3 or greater neutropenia/thrombocytopenia; or Grade 3 or greater hepatic toxicity; or inability of the patient to take 75% or more of the planned UFT/leucovorin; or radiotherapy interruption of greater than 1 week. The MTD for UFT/leucovorin was exceeded by one dose level when a certain dose caused DLT in 2 or more patients of 6. RESULTS: Five evaluable patients had Stage I resectable disease but had pathologic adenopathy. Seven had Stage II unresectable disease. Compliance with therapy was excellent. At a daily dose of 300 mg/m(2) of UFT, we noticed minimal diarrhea and hematologic toxicity with mild-moderate nausea, anorexia, and fatigue. Three patients had Grade 4 toxicity: 1 had neutropenia on Day 38, 1 had diarrhea on Day 55, and 1 had vomiting on Day 15. CONCLUSION: Oral UFT/leucovorin and radiation therapy offers patients a viable treatment option for pancreatic cancer. The major known toxicity of diarrhea was tolerable. The MTD was not reached in this study. Our current plan is to expand this into a Phase I/II trial beginning at a UFT dose of 300 mg/m(2) and correlate this with clinical pharmacologic parameters. The potential benefit of long bioavailability and oral delivery of UFT compares favorably with continuous infusion regimens without the added morbidity of a catheter and pump. 相似文献
99.
Many physicians consider the prognosis exceptionally poor for patients with localized non-small cell lung cancer who are not eligible for surgery, either because of the extent of their disease or because a coexisting medical condition precludes surgery. Thus, these patients frequently are not offered aggressive curative therapy. However, the disease of many of these patients is potentially curable and should be considered for curative treatment. Although pathologic data from surgical specimens are useful in predicting prognosis, many prognostic factors have also been identified for medically inoperable and locally advanced, unresectable disease. Several of these prognostic factors can and should be used clinically to estimate the risk of lymph node involvement within the clinically uninvolved mediastinum, thereby aiding in the design of radiation therapy fields, and to estimate prognosis, thereby helping to determine which patients should be offered aggressive therapy with curative intent. 相似文献
100.