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61.
Aude Buil Laurence Caeymaex Sophie Mero Carol Sankey Gisèle Apter Emmanuel Devouche 《Journal of neonatal nursing : JNN》2019,25(2):86-92
Purpose
To test the effects of a new skin-to-skin Supported Diagonal Flexion (SDF) positioning on maternal stress, postpartum depression risk and skin-to-skin daily practice, in comparison with the usual Kangaroo Care in Upright positioning, during the first weeks after very premature birth.Design
Thirty-four mothers and their very preterm infants were assigned to one of the two Kangaroo Care positioning, either the Upright (n?=?17) or the SDF positioning (n?=?17). Maternal risk for depression and stress feelings were assessed through questionnaires before the first kangaroo care, 15 days later and at 40 weeks and 3 months corrected age. Data on daily kangaroo care practice was collected during 15 consecutive days starting from the very first skin-to-skin session.Results
The depression risk score was significantly lower in SDF positioning mothers after 15 days of skin-to-skin practice and at 40 weeks and 3 months corrected age. In the SDF group, mothers chose to practice Kangaroo Care during a significantly longer period of time per session.Conclusion
Our results support the hypothesis of a positive impact of SDF Kangaroo positioning on maternal postpartum risk of depression and skin-to-skin practice. 相似文献62.
63.
Hlne Vallet Pascal Seve Lucie Biard Jean Baptiste Fraison Philip Bielefeld Laurent Perard Boris Bienvenu Sbastien Abad Aude Rigolet Alban Deroux Damien Sene Antoinette Perlat Isabelle Marie Elodie Feurer Eric Hachulla Olivier Fain Gaëlle Clavel Sophie Riviere Pierre‐Alban Bouche Julie Gueudry Gregory Pugnet Phuc Le Hoang Matthieu Resche Rigon Patrice Cacoub Bahram Bodaghi David Saadoun 《Arthritis \u0026amp; Rheumatology》2016,68(6):1522-1530
64.
Anne-Laure Adra Marie-Gabrielle Vigue Fabienne Dalla Vale Lydia Ichay Pierre Raynaud Aude Mariani Denis Morin 《Pediatric nephrology (Berlin, Germany)》2010,25(9):1765-1769
Mycoplasma pneumoniae-associated nephritis has been reported in children with various pathological findings. It nevertheless remains an uncommon
disease and, within this clinical context, endo-and extracapillary glomerulonephritis in a child has never been described.
We report here a case of a 3-year-old girl diagnosed with severe crescentic glomerulonephritis associated with M. pneumoniae infection who presented with nephrotic syndrome and impaired renal function. The serum C3 complement level was initially
low but returned to normal after 1 month. Two courses of three methylprednisolone pulses were administered in association
with plasmapheresis and, secondarily, mycophenolate mophetil. This treatment regimen led to disease remission and a favorable
renal outcome at the 6-month follow-up. However, the treatment guidelines in this situation remain debatable. 相似文献
65.
In a context of growing awareness of aquatic pollution impacts, there is an increasing need to develop methods for hazard and risk assessment of pollutants. For this purpose, in vitro models such as fish cell lines warrant to be evaluated as possible alternative to in vivo fish testing, and new toxicity endpoints such as genotoxicity deserve to be considered. This study assesses the interest of the formamido pyrimidine glycosylase (Fpg)-modified comet assay applied to three fish cell lines (RTL-W1, RTG-W1, and PLHC-1) regarding the sensitivity of the system for measuring genotoxicity of various classes of pollutants. Cytochrome P450-dependent EROD activity has also been measured to evaluate the importance of the biotransformation capacity of the cell lines in genotoxicity assessment. For all cell lines and chemicals tested, a concentration dependent genotoxic effect was observed with a 10- to 1000-fold increased sensitivity when using the Fpg-protocol compared to the standard comet assay. Such a modified assay led in particular to improve the detection threshold of oxidative and alkylating DNA damages following exposure at environmentally relevant contaminant concentrations and could partly compensate for the lower sensitivity of cell lines versus whole organism testing often cited as a limit of in vitro testing. 相似文献
66.
67.
Background
Low socioeconomic position predicts risk of substance abuse, yet few studies tested the role of preexisting familial and individual characteristics.Methods
Data come from the TEMPO (Trajectoires Epidémiologiques en Population) study (community sample in France, 1991–2009, n = 1103, 22–35 years in 2009) set up among offspring of participants of an epidemiological study (GAZEL). Past 12-month substance use was assessed in 2009 by self-completed mail survey: regular tobacco smoking, alcohol abuse (AUDIT), cannabis use, problematic cannabis use (CAST), other illegal drug use. Socioeconomic position was defined by educational attainment, occupational grade, employment stability and unemployment. Covariates included demographics (age, sex, relationship status, parenthood), family background (parental income, parental tobacco smoking, parental alcohol use), and juvenile characteristics (psychological problems, academic difficulties) measured longitudinally.Results
35.8% of study participants were regular smokers, 14.3% abused alcohol, 22.6% used cannabis (6.3% had problematic cannabis use) and 4.1% used other illegal drugs. Except for alcohol abuse, substance use rates were systematically higher in individuals with low, rather than intermediate/high, socioeconomic position (age and sex-adjusted ORs from 1.75 for cannabis use to 2.11 for tobacco smoking and 2.44 for problematic cannabis use). In multivariate analyses these socioeconomic disparities were decreased, but remained statistically significant (except for illegal drugs other than cannabis).Conclusions
Tobacco smoking, alcohol, cannabis and polysubstance use are common behaviors among young adults, particularly those experiencing socioeconomic disadvantage. Interventions aiming to decrease substance abuse and reduce socioeconomic inequalities in this area should be implemented early in life. 相似文献68.
69.
Killian A Di Fiore F Le Pessot F Blanchard F Lamy A Raux G Flaman JM Paillot B Michel P Sabourin JC Tuech JJ Michot F Kerckaert JP Sesboüé R Frebourg T 《Gastroenterology》2007,132(2):645-653
BACKGROUND & AIMS: Several quantitative genetic alterations have been suggested to have in colorectal cancer (CRC) either a prognostic or a therapeutic predictive value. Routine detection of these alterations is limited by the absence of simple methods. METHODS: The somatic quantitative multiplex polymerase chain reaction of short fluorescent fragments (QMPSF) is based on the simultaneous amplification under quantitative conditions of several dye-labeled targets both from tumor and nonmalignant tissues. For each patient, the resulting QMPSF fluorescent profiles are superimposed, and quantitative changes are simply detected by an increase or decrease of the corresponding fluorescent peaks. Two assays were developed and applied to 57 CRC: a "bar code" exploring several loci with known prognostic value and a "kinogram" studying the copy number change of kinase genes, against which inhibitors have been developed. RESULTS: The bar code revealed that the most frequent alterations were the gain of AURKA/20q13 (53%) and MYC/8q24 (39%) and heterozygous deletion of DCC/18q21.3 (39%) and TP53/17p13 (23%). The kinogram detected a gene copy number increase for AURKA, PTK2, MET, and EGFR in 53%, 37%, 33%, and 28% of the tumors, respectively. QMPSF results were validated by comparative genomic hybridization and multiplex real-time polymerase chain reaction on genomic DNA. CONCLUSIONS: The somatic QMPSF is a simple method able to detect simultaneously on a routine basis several quantitative changes in tumors. Its flexibility will allow the integration of clinically relevant genes. This high throughput method should be a valuable complementary tool of fluorescent in situ hybridization and comparative genomic hybridization. 相似文献
70.
A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development 下载免费PDF全文