重度脑外伤患者通过阶段性评估计划性拔除导管1例报道

目的 对重度脑外伤患者实施阶段性护理评估,促进患者计划性拔除导管。     

基于App的疾病自我评估在类风湿关节炎患者中的应用

目的探讨基于App的疾病自我评估对类风湿关节炎患者疾病活动度的影响。方法将风湿免疫科门诊就诊的类风湿关节炎患者119例纳入本研究,采用中心化随机分组并剔除失访者后最终纳入110例患者,其中实验组56例,对照组54例。实验组使用智能疾病管理系统(SSDM)进行疾病评估管理,对照组进行常规医疗随访。分别于基线期及24周后对患者进行病情评估,比较2组患者病情活动度。结果经24周治疗后,2组疾病活动度评分(DAS28)、关节疼痛数量、健康评估问卷(HAQ)评分、血沉改善程度比较,差异有统计学意义(P0.05),但2组简明生活质量量表(SF-36)评分比较,差异无统计学意义(P0.05)。结论基于App的疾病自我评估有利于类风湿关节炎患者的病情控制,有利于患者关节功能改善和生活质量的提高,对患者疾病结局有积极意义。     

Facile construction of Fe,N and P co-doped carbon spheres by carbothermal strategy for the adsorption and reduction of U(vi)

In this work, nitrogen and phosphorus co-doped magnetic carbon spheres encapsulating well-dispersed active Fe nanocrystals (Fe/P-CN) were fabricated via a simple copolymer pyrolysis strategy. Benefiting from heteroatoms doping, Fe/P-CN could primarily adsorb soluble U(vi) ions through abundant functional groups, and subsequently, the adsorbed U(vi) could be reduced to insoluble U(iv) by Fe nanocrystals. Fe/P-CN pyrolyzed at 800 °C (Fe/P-CN-800) exhibited excellent U(vi) removal capacity of 306.76 mg g⁻¹, surpassing nitrogen and phosphorus co-doped carbon spheres and nano zero-valent iron. In addition, the magnetic separation and thermal reactivation properties endow Fe/P-CN-800 with excellent reusability. This research, especially, provides a promising synergistic adsorption and reduction strategy to effectively remove U(vi) using heteroatom-doped composites.

The constructed novel magnetic carbon sphere co-doped by N, P, Fe (Fe/P-CN) exhibits high U(vi) removal efficiency, excellent magnetic separation and reusability, evidencing the potential practical applications in environmental remediation.     

The fabrication and characterization of CeO2/Cu2O nanocomposites with enhanced visible-light photocatalytic activity

Spherical Cu₂O nanocrystals were synthesized and CeO₂/Cu₂O nanocomposites were successfully prepared from the spherical Cu₂O nanocrystals. Characterization analysis was performed via scanning electron microscope (SEM), transmission electron microscope (TEM), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and UV-visible diffusion reflectance spectroscopy (DRS) studies. In comparison with the Cu₂O nanocrystals, the CeO₂/Cu₂O nanocomposites exhibited high visible-light-induced photocatalytic activity for the degradation of methyl orange solution. Radical trapping experiments proved that photo-generated electrons played a very minor role, while photo-generated holes and superoxide radicals played a major role in the degradation process. The CeO₂/Cu₂O system could cause the internal energy band to bend, leading to the building of internal electric fields. The excited electrons and holes easily moved in opposite directions, promoting the effective separation of charges, which obviously enhanced the visible light photocatalytic activity of the catalyst.

Spherical Cu₂O nanocrystals were synthesized and CeO₂/Cu₂O nanocomposites were successfully prepared from the spherical Cu₂O nanocrystals.     

Heterogeneous synthesis and electrochemical performance of LiMnPO4/C composites as cathode materials of lithium ion batteries

In this study, a facile yet efficient interfacial hydrothermal process was successfully developed to fabricate LiMnPO₄/C composites. In this strategy, the walls of carbon nanotubes were employed as heterogeneous nucleation interfaces and biomass of phytic acid (PA) as an eco-friendly phosphorus source. By comparing the experimental results, a reasonable nucleation-growth mechanism was proposed, suggesting the advantages of interfacial effects. Meanwhile, the as-synthesized LiMnPO₄/C samples exhibited superior rate performances with discharge capacities reaching 161 mA h g⁻¹ at C/20, 134 mA h g⁻¹ at 1C, and 100 mA h g⁻¹ at 5C. The composites also displayed excellent cycling stabilities by maintaining 95% of the initial capacity over 100 continuous cycles at 1C. Electrochemical impedance spectroscopy showed that the superior electrochemical performances were attributed to the low charge-transfer resistance and elevated diffusion coefficient of lithium ions. In sum, the proposed approach for the preparation of LiMnPO₄/C composites looks promising for future production of composite electrode materials for high-performance lithium-ion batteries.

A heterogeneous nucleation technique was used to prepare LiMnPO₄/C. The walls of carbon nanotubes were employed as nucleation interfaces and phytic acid as an eco-friendly phosphorus source. The product exhibits superior electrochemical performance.     

The incidence of radioepidermitis and the dose-response relationship in parotid gland cancer patients treated with 125I seed brachytherapy

Background

We studied the incidence and dose–response relationship of radioepidermitis in parotid gland carcinoma patients treated with [¹²⁵I] seed brachytherapy in the hopes of designing an optimized pre-implant treatment plan that would reduce the incidence and severity of radioepidermitis in patients receiving this therapy.

Patients and methods

Between January 2007 and May 2010, 100 parotid gland cancer patients were treated postoperatively with [¹²⁵I] seed brachytherapy. The matched peripheral dose (MPD) was 80–140 Gy, and [¹²⁵I] seed activity was 0.7–0.8 mCi. The mean dose delivered to the skin was calculated in the post-implant CT on day 0 following implantation. Grades of acute and late dermatitis were evaluated at 2, 6, 12, and 18 months post-implantation.

Results

Most patients experienced grade 0–2 acute and late skin side effects (86 and 97?%, respectively), though a small subset developed severe complications. Most grade 1–3 effects resolved within 6 months of implantation, though some grade 1–3 effects and all grade 4 effects remained unchanged throughout the 18-month follow-up period. Grade 3 and 4 effects were most prominent (75 and 25?%, respectively) with doses of 110–140 Gy; doses higher than 140 Gy produced only grade 4 effects.

Conclusion

[¹²⁵I] seed brachytherapy produced acceptable levels of acute and late radioepidermitis with a good clinical outcome. A mean dose under 100 Gy delivered to the skin was safe, though doses of 110–140 Gy should be given with caution and extra monitoring; doses greater than 140 Gy are dangerous and likely to produce grade 4–5 effects.