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61.
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Fleischer AC; Dudley BS; Entman SS; Baxter JW; Kalemeris GC; James AE Jr 《Radiology》1987,162(2):307-310
The depth of myometrial invasion by endometrial carcinoma was evaluated using real-time sonography (US) in 20 patients with histologically proved adenocarcinoma of the endometrium. In 14 of 20 (70%) cases, US-based estimation of the depth of myometrial invasion was within 10% of the actual measurement in the gross specimen. The US-based estimation of tumor invasion was low in seven patients, high in four patients, and agreed with pathologic findings (+/- 5%) in nine patients. In four patients with polypoid intraluminal extension of tumor, a deeply invasive tumor was suspected on US but was not found on pathologic examination. In 12 superficially invasive tumors, the continuity of the demarcating subendometrial halo was intact in nine and incomplete in three. In six patients with deeply invasive tumors, this zone was partially disrupted in four, totally disrupted in one, and intact in one. Errors of estimation of the depth of myometrial invasion on US most frequently occurred when a tumor had a significant intraluminal polypoid extension. Demonstration of a subendometrial halo usually indicated superficial invasion, whereas the absence of a halo was frequently associated with deep invasion. 相似文献
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Jeremy Whelan MD Daniel Patterson MD Martha Perisoglou MD Stefan Bielack MD Neyssa Marina MD Sigbjorn Smeland MD Mark Bernstein MD 《Pediatric blood & cancer》2010,54(3):350-354
Interferons, a group of cytokines with antiangiogenic, direct antitumour and immunostimulating properties, have shown significant activity against osteosarcoma in vitro and in xenograft models. They have also been used in osteosarcoma clinical trials as a single adjuvant to surgery, with an apparent increase in relapse‐free survival. In the ongoing EURAMOS 1 clinical trial, interferon α‐2b is evaluated as an adjuvant treatment in osteosarcoma. This article reviews the rationale for the use of interferon in cancer with special reference to the treatment of osteosarcoma, including all published data of clinical efficacy in this disease. Pediatr Blood Cancer 2010;54:350–354. © 2009 Wiley‐Liss, Inc. 相似文献
65.
K Winkler P Bieling S Bielack G Delling C Dose H Jürgens R Kotz J Ritter M Salzer-Kuntschik 《Clinical orthopaedics and related research》1991,(270):79-86
The use of aggressive chemotherapy undoubtedly has brought about a dramatic increase in the cure rate of osteosarcoma. The authors' investigations have increased the authors' knowledge of chemotherapy for osteosarcoma, the differential efficacy of currently used agents, and the pronounced schedule dependency and relative route independency of their efficiency. The authors were able to confirm the prognostic significance of tumor response after preoperative chemotherapy. Preoperative chemotherapy in itself has facilitated and promoted limb-salvage surgery. Also, more patients can be cured today by use of aggressive thoracic surgery in case of primary or secondary pulmonary metastases. The authors' efforts to steadily increase metastasis-free survival rates by intensifying chemotherapy in this series of studies, however, have been only moderately successful. Still, chemotherapy-related acute toxicity is considerable and increases with aggressiveness of treatment, and the manifestations of late toxicity may continue to increase with follow-up time. Future trials should be targeted toward exploration of the minimum indispensable amount of toxic treatment yielding comparable or even better results than those currently attainable. 相似文献
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The incidence of thromboembolitic events in patients undergoing transfemoral angiography was examined using indium-111 labeled platelets. Twenty-seven patients received approximately 300 muCi of autologous labeled platelets at least 3 hours before angiography and were scanned with a gamma camera immediately before and after angiography. All patients were free of clinically obvious complications in the 1-2 day period after angiography. Our results showed evidence of platelet deposition at 21 sites other than the puncture site in 12 (44%) patients. Most platelet deposition (54%) occurred along the region between the puncture site and the aortic bifurcation; 24% occurred at sites not traversed by the catheter. At the puncture site itself, there was substantial platelet uptake in 44% of patients. This study indicates the need for further work in determining the most suitable catheter material and in assessing the efficacy of other measures such as anticoagulant or antiplatelet therapy. 相似文献
68.
老年大鼠松质骨骨重建的组织形态计量学研究 总被引:1,自引:0,他引:1
目的:研究老年大鼠及在促骨合成药前列腺素E2(PGE2)作用下松质骨骨重建和骨建造的形态计量学改变,探讨动物骨重建形态学新参数测量方法及其意义。方法:50只20月龄雄性Wistar大鼠随机分成5组,年龄对照组(基础组、10d和30d年龄对照组),PGE2给药组(分别10d和30d给予3mg/kg/d处理组)。用体内双荧光标记,不脱钙组织切片,粘合线(cement line)染色,骨组织形态计量学方法,测定骨重建和骨建造参数。结果:20月龄雄性大鼠胫骨近端松质骨的形成表面大多数为骨重建单位(占63.3%),少部分为骨建造单位(占26.7%);PGE2用药后骨重建单位增加1.5倍,骨建造单位增加4倍,比值倒置,成骨细胞10d时明显增多。说明PGE2通过刺激成骨细胞骨合成而介民导骨建造性骨增加和骨重建性骨量增加,并以前为主。结论:老年雄性大鼠 松质骨以骨重建活动为主,仍有骨建造活动。PGE2主要通过刺激成骨细胞骨建造而增加骨量。 相似文献
69.
I. A. NÆSS S. C. CHRISTIANSEN† P. ROMUNDSTAD‡ S. C. CANNEGIETER† F. R. ROSENDAAL†§ J. HAMMERSTRØM 《Journal of thrombosis and haemostasis》2007,5(4):692-699
Background: Estimates of the incidence of venous thrombosis (VT) vary, and data on mortality are limited. Objectives: We estimated the incidence and mortality of a first VT event in a general population. Methods: From the residents of Nord‐Trøndelag county in Norway aged 20 years and older (n = 94 194), we identified all cases with an objectively verified diagnosis of VT that occurred between 1995 and 2001. Patients and diagnosis characteristics were retrieved from medical records. Results: Seven hundred and forty patients were identified with a first diagnosis of VT during 516 405 person‐years of follow‐up. The incidence rate for all first VT events was 1.43 per 1000 person‐years [95% confidence interval (CI): 1.33–1.54], that for deep‐vein thrombosis (DVT) was 0.93 per 1000 person‐years (95% CI: 0.85–1.02), and that for pulmonary embolism (PE) was 0.50 per 1000 person‐years (95% CI: 0.44–0.56). The incidence rates increased exponentially with age, and were slightly higher in women than in men. The 30‐day case‐fatality rate was higher in patients with PE than in those with DVT [9.7% vs. 4.6%, risk ratio 2.1 (95% CI: 1.2–3.7)]; it was also higher in patients with cancer than in patients without cancer [19.1% vs. 3.6%, risk ratio 3.8 (95% CI 1.6–9.2)]. The risk of dying was highest in the first months subsequent to the VT, after which it gradually approached the mortality rate in the general population. Conclusions: This study provides estimates of incidence and mortality of a first VT event in the general population. 相似文献
70.