全文获取类型
收费全文 | 919篇 |
免费 | 27篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 35篇 |
妇产科学 | 8篇 |
基础医学 | 69篇 |
口腔科学 | 33篇 |
临床医学 | 60篇 |
内科学 | 110篇 |
皮肤病学 | 30篇 |
神经病学 | 3篇 |
特种医学 | 101篇 |
外科学 | 111篇 |
综合类 | 260篇 |
预防医学 | 30篇 |
眼科学 | 7篇 |
药学 | 41篇 |
中国医学 | 1篇 |
肿瘤学 | 56篇 |
出版年
2023年 | 4篇 |
2022年 | 4篇 |
2021年 | 21篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 11篇 |
2017年 | 10篇 |
2016年 | 9篇 |
2015年 | 29篇 |
2014年 | 23篇 |
2013年 | 24篇 |
2012年 | 23篇 |
2011年 | 23篇 |
2010年 | 53篇 |
2009年 | 46篇 |
2008年 | 36篇 |
2007年 | 44篇 |
2006年 | 59篇 |
2005年 | 39篇 |
2004年 | 53篇 |
2003年 | 23篇 |
2002年 | 25篇 |
2001年 | 17篇 |
2000年 | 19篇 |
1999年 | 27篇 |
1998年 | 40篇 |
1997年 | 49篇 |
1996年 | 52篇 |
1995年 | 32篇 |
1994年 | 29篇 |
1993年 | 9篇 |
1992年 | 8篇 |
1991年 | 5篇 |
1990年 | 7篇 |
1989年 | 7篇 |
1988年 | 15篇 |
1987年 | 9篇 |
1986年 | 10篇 |
1985年 | 7篇 |
1984年 | 11篇 |
1983年 | 4篇 |
1982年 | 7篇 |
1981年 | 6篇 |
1980年 | 4篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 2篇 |
1975年 | 2篇 |
排序方式: 共有956条查询结果,搜索用时 0 毫秒
51.
Sujit K Bhutia Sanjaya K Mallick Stanley M Stevens Laszlo Prokai Jamboor K Vishwanatha Tapas K Maiti 《Toxicology in vitro》2008,22(2):344-351
In our previous study, Abrus agglutinin showed antitumor activity both native and heat-denatured condition in mouse model. The purpose of this study is to explore the presence of anticancer peptide in agglutinin, and to elucidate the mechanism of its activity in vitro. A tryptic digested Abrus agglutinin peptide fractions obtained from 10-kDa molecular weight cut off membrane permeate (10 kMPP), was found to have selective antiproliferative activity (1-10 microg/ml) on several tumor cell lines in vitro without having any cytotoxic effect on normal cell lines with dose of 100 microg/ml. Analysis of the growth inhibitory mechanism in HeLa cells revealed nuclear fragmentation and condensation with appearance of the sub-G 0/G1 peak indicative of apoptosis. Furthermore, the peptide fraction induced the apoptosis signal via generation of reactive oxygen species and decrease in the Bcl-2/Bax ratio thereby inducing mitochondrial permeability transition with consequent activation of caspase-3, finally leads to DNA fragmentation, and the hallmark of apoptosis. LC-MS/MS analysis reflected the molecular masses of peptides in 10 kMPP were in the range of 500 Da to 3000 Da. The significant antitumor activity of 10 kMPP deserves further laboratory and in vivo experimentation. 相似文献
52.
S Muralidhar M Gulati B Kumar SK Sharma K Suman PB Roy 《Journal of Medical Imaging and Radiation Oncology》1996,40(2):106-108
A study was undertaken to determine the usefulness of ultrasonography as an investigative tool, and its role in deciding the management of Peyronie's disease. Fifteen patients with Peyronie's disease were studied by ultrasonography. The plaque could be demonstrated in all patients. The dimensions of the plaque varied from less than 1 cm to more than 7cm in length and 2-4mm in thickness. The disease was active in 26% of the patients, as indicated by the presence of hypoechoic areas around a central region of hyperechoism. Ultrasonogram was more accurate than clinical assessment in delineating the extent of lesions. In one-third of the patients, sonography demonstrated the plaques to be more extensive than had been detected by clinical examination. Calcification and activity of disease (which are clearly defined by ultrasonogram) are determining factors in the management of Peyronie's disease. This information allows the surgeon to select the modality of treatment, the timing of surgery and extent of excision. Thus, ultrasonography plays a vital role in the preliminary investigation and management of Peyronie's disease. 相似文献
53.
54.
JR Bapuraj V Ojili SK Singh GRV Prasad N Khandelwal S Suri 《Journal of Medical Imaging and Radiation Oncology》2006,50(2):179-182
Leiomyoma of the vagina is a very rare tumour of the lower urogenital tract. These slow‐growing masses may be asymptomatic or present with pain, dyspareunia or urinary symptoms. Rarely, these tumours may present with life‐threatening haemorrhage. These hypervascular tumours are treated by surgical excision. Preoperative embolization therefore may aid in devascularization of these tumours before surgical excision. We present the MRI features of a case of vaginal leiomyoma, which was managed by preoperative embolization and was then excised in toto. To the best of our knowledge, this is the first report where preoperative embolization was performed before excision of a vaginal leiomyoma with minimal peroperative blood loss. 相似文献
55.
RJ Gilbertson E Harris SK Pandey P Kelly W Myers 《Archives of disease in childhood》1996,75(3):194-198
Paracetamol is the commonest agent employed in self poisoning, however it is not clear whether adolescents possess insight into the serious complications associated with its misuse. Using a one page questionnaire, the availability, usage, and knowledge of toxicity of paracetamol among 1147 American and British adolescents was assessed. Although 90% of all students recognised that paracetamol could kill, the great majority of students overestimated the lethal dose. In addition, while knowledge regarding side effects of paracetamol was poor the drug was widely available to, and used by, the study population. It is proposed that gross overestimation of the number of tablets required to kill, poor understanding of paracetamol side effects, and wide availability of the drug contribute to its frequent use in adolescent suicidal behaviour. The inclusion of some over-the-counter medications in school drug education programs in addition to tighter control of the availability of paracetamol may help reduce the problem of adolescent self poisoning. 相似文献
56.
57.
58.
Uterine leiomyomas in the infertile patient: preoperative localization with MR imaging versus US and hysterosalpingography 总被引:2,自引:0,他引:2
Eleven women with a history of infertility and uterine leiomyomas underwent magnetic resonance (MR) imaging of the pelvis prior to myomectomy. Nine also underwent preoperative pelvic ultrasonography (US), and ten underwent hysterosalpingography. All studies were interpreted prospectively by independent observers. With each imaging modality, the location (one of 11 anatomic segments), size, and appearance of detected uterine leiomyomas were determined and compared with surgical and histologic findings. Among the nine patients who underwent both MR and US, the sensitivity (85%) and accuracy (94%) of MR imaging for abnormal segments was significantly better than that of US (sensitivity = 69%, P = .015; accuracy = 87%, P = .043). For the ten patients who underwent both MR and hysterosalpingography, the sensitivity (91%) and accuracy (96%) of MR imaging was better than that of hysterosalpingography (sensitivity = 18%, P = .0005; accuracy = 72%, P = .0005). The specificities of the three modalities did not significantly differ (100%, 97%, and 98% for MR, US, and hysterosalpingography, respectively). These data suggest that MR imaging is superior to US or hysterosalpingography for preoperatively locating uterine leiomyomas. 相似文献
59.
MAGNOLOL REDUCES INFARCT SIZE AND SUPPRESSES VENTRICULAR ARRHYTHMIA IN RATS SUBJECTED TO CORONARY LIGATION 总被引:7,自引:0,他引:7
1. Magnolol is an active component of Magnolia officinalis. It is 1000-times more potent than α-tocopherol in inhibiting lipid peroxidation in rat heart mitochondira. In the present study, the in vivo antiarrhythmic and anti-ischaemic effects of magnolol in coronary ligated rats were investigated. 2. Male Sprague-Dawley rats were anaesthetized with urethane. Magnolol, at dosages of 10?7, 10?8 and 10?9 g/kg, was adminstered intravenously 15 min before ligation of the coronary artery. 3. The incidence and duration of ventricular tachycardia and ventricular fibrillation during 30 min coronary ligation were significantly reduced by magnolol. Ventricular arrhythmias during 10 min reperfusion after the relief of coronary ligation were also reduced. 4. In rats subjected to 4h coronary ligation, 10?7 and 10?8 g/kg magnolol significantly reduced infarct size. 5. We conclude that magnolol may protect the myocardium against ischaemic injury and suppress ventricular arrhythmia during ischaemia and reperfusion. 相似文献
60.