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991.
Victoria A. Malik Franziska Zajicek Laura A. Mittmann Johannes Klaus Sandra Unterseer Sandeep Rajkumar Benno Pütz Jan M. Deussing Inga D. Neumann Rainer Rupprecht Barbara Di Benedetto 《Journal of neuroscience research》2020,98(7):1433-1456
Perivascular astrocyte processes (PAP) surround cerebral endothelial cells (ECs) and modulate the strengthening of tight junctions to influence blood–brain barrier (BBB) permeability. Morphologically altered astrocytes may affect barrier properties and trigger the onset of brain pathologies. However, astrocyte-dependent mediators of these events remain poorly studied. Here, we show a pharmacologically driven elevated expression and release of growth/differentiation factor 15 (GDF15) in rat primary astrocytes and cerebral PAP. GDF15 has been shown to possess trophic properties for motor neurons, prompting us to hypothesize similar effects on astrocytes. Indeed, its increased expression and release occurred simultaneously to morphological changes of astrocytes in vitro and PAP, suggesting modulatory effects of GDF15 on these cells, but also neighboring EC. Administration of recombinant GDF15 was sufficient to promote astrocyte remodeling and enhance barrier properties between ECs in vitro, whereas its pharmacogenetic abrogation prevented these effects. We validated our findings in male high anxiety-related behavior rats, an animal model of depressive-like behavior, with shrunk PAP associated with reduced expression of the junctional protein claudin-5, which were both restored by a pharmacologically induced increase in GDF15 expression. Thus, we identified GDF15 as an astrocyte-derived trigger of astrocyte process remodeling linked to enhanced tight junction strengthening at the BBB. 相似文献
992.
Joanne Ng MD PhD Elisenda Cortès-Saladelafont MD Lucia Abela MD Pichet Termsarasab MD Kshitij Mankad FRCR Sniya Sudhakar FRCR Kathleen M. Gorman MD Simon J.R. Heales PhD Simon Pope PhD Lorenzo Biassoni MSc FRCP FEBNM Barbara Csányi MD John Cain FRCR PhD Karl Rakshi MBChB Helen Coutts MD Sandeep Jayawant MD FRCPCH Rosalind Jefferson MBBS PhD Deborah Hughes MSc Àngels García-Cazorla MD PhD Detelina Grozeva PhD F. Lucy Raymond MD PhD Belén Pérez-Dueñas MD PhD Christian De Goede MD Toni S. Pearson MD Esther Meyer PhD Manju A. Kurian MD PhD 《Movement disorders》2020,35(8):1357-1368
993.
Psychotherapie Forum - 相似文献
994.
Brian J. Roach Holly K. Hamilton Peter Bachman Aysenil Belger Ricardo E. Carrin Erica Duncan Jason Johannesen Joshua G. Kenney Gregory Light Margaret Niznikiewicz Jean Addington Carrie E. Bearden Emily M. Owens Kristin S. Cadenhead Tyrone D. Cannon Barbara A. Cornblatt Thomas H. McGlashan Diana O. Perkins Larry Seidman Ming Tsuang Elaine F. Walker Scott W. Woods Daniel H. Mathalon 《International journal of methods in psychiatric research》2020,29(2)
995.
The pathogenesis of mucosa-associated lymphoid tissue (MALT) lymphoma has been characterized as a dynamic process driven by lymphoma cell dependency on T-cell signaling, chronic antigenic stimulation of marginal zone B-cells and activation of the nuclear factor-kappa B signaling pathway. This concept is underlined by the strong causal connection of chronic Helicobacter pylori associated gastritis and MALT lymphoma development based on perpetual auto-antigenic stimulation of Helicobacter pylori-specific T-cells, but also its association with further potential infectious triggers and autoimmune disorders for extragastric lymphoma sites. Thus, given the dependency of MALT lymphoma cells on the tumor microenvironment, this specific entity appears highly suitable for immunomodulatory treatment strategies. Several approaches have been assessed in the last years including promising data on immunomodulatory agents “IMiDs” thalidomide and lenalidomide, macrolide antibiotics and antibodies. The aim of the present review is to discuss rationales for immunomodulatory therapies in MALT lymphoma and to present the statu quo on immunomodulatory and therefore chemotherapy-free treatment strategies for these patients. 相似文献
996.
997.
998.
Marco Cerrano Massimiliano Bonifacio Matteo Olivi Antonio Curti Michele Malagola Michelina Dargenio Anna Maria Scattolin Cristina Papayannidis Fabio Forghieri Carmela Gurrieri Ilaria Tanasi Patrizia Zappasodi Roberta La Starza Nicola Stefano Fracchiolla Patrizia Chiusolo Luisa Giaccone Maria Ilaria Del Principe Fabio Giglio Marzia Defina Claudio Favre Carmelo Rizzari Barbara Castella Giovanni Pizzolo Felicetto Ferrara Sabina Chiaretti Robin Fo 《Haematologica》2022,107(4):996
999.
1000.
Wilberg A. Moncada Arita Eduardo Smelin Perdomo Domínguez Astrid Yohaly Rivera Caballero Nelson A. EspinozaMoreno Mauricio E. Zavala Galeano Barbara R. DuPont Hctor M. RamosZaldívar 《Clinical Case Reports》2022,10(4)
Less than one percent of individuals with Down syndrome exhibit mosaicism, a biological phenomenon that describes an individual who has two or more genetically distinct cell lines. The percentage of mosaicism in different tissues can impact the presence of clinical findings and hinder cytogenetic diagnosis. We report a case of mosaicism for trisomy 21 diagnosed after multi‐tissue cytogenetic analysis of peripheral blood and buccal mucosa, associated with significant intellectual disability, dysmorphic facial features, congenital heart defects, macropenis, and imperforate anus. 相似文献