全文获取类型
收费全文 | 1015篇 |
免费 | 68篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 69篇 |
妇产科学 | 14篇 |
基础医学 | 115篇 |
口腔科学 | 35篇 |
临床医学 | 96篇 |
内科学 | 220篇 |
皮肤病学 | 18篇 |
神经病学 | 41篇 |
特种医学 | 154篇 |
外国民族医学 | 1篇 |
外科学 | 123篇 |
综合类 | 52篇 |
一般理论 | 2篇 |
预防医学 | 51篇 |
眼科学 | 11篇 |
药学 | 39篇 |
中国医学 | 4篇 |
肿瘤学 | 41篇 |
出版年
2022年 | 13篇 |
2021年 | 15篇 |
2020年 | 22篇 |
2019年 | 17篇 |
2018年 | 28篇 |
2017年 | 23篇 |
2016年 | 19篇 |
2015年 | 24篇 |
2014年 | 37篇 |
2013年 | 48篇 |
2012年 | 59篇 |
2011年 | 39篇 |
2010年 | 61篇 |
2009年 | 61篇 |
2008年 | 41篇 |
2007年 | 38篇 |
2006年 | 21篇 |
2005年 | 21篇 |
2004年 | 20篇 |
2003年 | 13篇 |
2002年 | 16篇 |
2001年 | 17篇 |
2000年 | 13篇 |
1999年 | 9篇 |
1998年 | 42篇 |
1997年 | 34篇 |
1996年 | 39篇 |
1995年 | 40篇 |
1994年 | 24篇 |
1993年 | 22篇 |
1992年 | 6篇 |
1991年 | 11篇 |
1990年 | 10篇 |
1989年 | 17篇 |
1988年 | 15篇 |
1987年 | 10篇 |
1986年 | 16篇 |
1985年 | 11篇 |
1984年 | 13篇 |
1983年 | 16篇 |
1982年 | 14篇 |
1981年 | 14篇 |
1980年 | 16篇 |
1979年 | 5篇 |
1978年 | 9篇 |
1977年 | 2篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1969年 | 2篇 |
1949年 | 1篇 |
排序方式: 共有1089条查询结果,搜索用时 31 毫秒
21.
Bajwa Farhan O’Connor Ryan Ananthasubramaniam Karthikeyan 《Heart failure reviews》2022,27(5):1471-1484
Heart Failure Reviews - Cardiac amyloidosis, once considered a rare disease, has garnered significant attention over the last few years due to three key reasons: first, increased... 相似文献
22.
Pimentel M Constantino T Kong Y Bajwa M Rezaei A Park S 《Digestive diseases and sciences》2004,49(1):73-77
Treatment of small intestinal bacterial overgrowth is frustrated by the low efficacy of antibiotics. Elemental diets have been shown to reduce enteric flora. In this study, we evaluate the ability of an elemental diet to normalize the lactulose breath test (LBT) in IBS subjects with abnormal breath test findings. Consecutive subjects with IBS and abnormal LBT suggesting the presence of bacterial overgrowth underwent a 2-week exclusive elemental diet. The diet consisted of Vivonex Plus (Novartis Nutrition Corp., Minneapolis, MN) in a quantity based on individual caloric requirement. On day 15 (prior to solid food), subjects returned for a follow-up breath test and those with an abnormal LBT were continued on the diet for an additional 7 days. The ability of an elemental diet to normalize the LBT was determined for days 15 and 21. A chart review was then conducted to evaluate any clinical benefit 1 month later. Of the 93 subjects available for analysis, 74 (80%) had a normal LBT on day 15 of the elemental diet. When those who continued to day 21 were included, five additional patients normalized the breath test (85%). On chart review, subjects who successfully normalized their breath test had a 66.4 +/- 36.1% improvement in bowel symptoms, compared to 11.9 +/- 22.0% in those who failed to normalize (P < 0.001). An elemental diet is highly effective in normalizing an abnormal LBT in IBS subjects, with a concomitant improvement in clinical symptoms. 相似文献
23.
Kenneth Hahn Rita Shah Yoseph Shalev Donald H. Schmidt Tanvir Bajwa 《Catheterization and cardiovascular interventions》1995,35(4):321-327
Thoracic outlet syndrome (TOS) associated with congenital clavicular pseudoarthrosis is rare in adults and often misdiagnosed. In this case report, we describe an adult female who was found to have thromoosis of the subclavian and axillary arteries with embolization documented by invasive angiography. This unusual vascular manifestation of TOS should remind physicians that anatomic derangements may predispose to upper extremity ischemia. © 1995 Wiley-Liss, Inc. 相似文献
24.
Usman Arshad Adnan Mujahid Peter Lieberzeit Adeel Afzal Sadia Zafar Bajwa Naseer Iqbal Sumaira Roshan 《RSC advances》2020,10(57):34355
Monitoring antimalarial drugs is necessary for clinical assays, human health, and routine quality control practices in pharmaceutical industries. Herein, we present the development of sensor coatings based on molecularly imprinted polymers (MIPs) combined with quartz crystal microbalance (QCM) for sensitive and selective gravimetric detection of an antimalarial drug: artemether. The MIP coatings are synthesized by using artemether as the template in a poly(methacrylic acid-co-ethylene glycol dimethacrylate) matrix. Artemether-MIP and the non-imprinted polymer (NIP) control or reference layers are deposited on 10 MHz dual-electrode QCM by spin coating (187 ± 9 nm layer thickness after optimization). The coatings are characterized by FTIR spectroscopy and atomic force microscopy that reveal marked differences among the MIP and NIP. The MIP-QCM sensor exhibits high sensitivity (0.51 Hz ppm−1) with sub-10 ppm detection and quantification limits. The MIP-QCM sensor also exhibits a 6-fold higher sensitivity compared to the NIP-QCM, and a dynamic working range of 30–100 ppm. The response time of MIP-QCM devices for a single cycle of analyte adsorption, signal saturation, and MIP regeneration is less than 2.5 min. The sensor also demonstrates selectivity factors of artemether-MIP of 2.2 and 4.1 compared to artemisinin and lumefantrine, respectively. Reversibility tests reveal less than 5% variation in sensor responses over three cycles of measurements at each tested concentration. The MIP-QCM showed lower detection limits than conventional HPLC-UV, and faster response time compared to HPLC-UV and liquid chromatography-mass spectrometry (LC-MS).Chemical structures of the antimalarial drugs: artemisinin, artemether (a methyl ether derivative of artemisinin), and lumefantrine. 相似文献
25.
Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice 总被引:12,自引:0,他引:12
下载免费PDF全文
![点击此处可从《Proceedings of the National Academy of Sciences of the United States of America》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Lora K. Heisler Hung-Ming Chu Thomas J. Brennan Jean A. Danao Preetpaul Bajwa Loren H. Parsons Laurence H. Tecott 《Proceedings of the National Academy of Sciences of the United States of America》1998,95(25):15049-15054
The brain serotonin (5-hydroxytryptamine; 5-HT) system is a powerful modulator of emotional processes and a target of medications used in the treatment of psychiatric disorders. To evaluate the contribution of serotonin 5-HT1A receptors to the regulation of these processes, we have used gene-targeting technology to generate 5-HT1A receptor-mutant mice. These animals lack functional 5-HT1A receptors as indicated by receptor autoradiography and by resistance to the hypothermic effects of the 5-HT1A receptor agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Homozygous mutants display a consistent pattern of responses indicative of elevated anxiety levels in open-field, elevated-zero maze, and novel-object assays. Moreover, they exhibit antidepressant-like responses in a tail-suspension assay. These results indicate that the targeted disruption of the 5-HT1A receptor gene leads to heritable perturbations in the serotonergic regulation of emotional state. 5-HT1A receptor-null mutant mice have potential as a model for investigating mechanisms through which serotonergic systems modulate affective state and mediate the actions of psychiatric drugs. 相似文献
26.
Genetic and non‐genetic factors that increase the risk of non‐syndromic cleft lip and/or palate development
下载免费PDF全文
![点击此处可从《Oral diseases》网站下载免费的PDF全文](/ch/ext_images/free.gif)
27.
Joseph C. Gigliotti Liping Huang Amandeep Bajwa Hong Ye Eric H. Mace John A. Hossack Kambiz Kalantari Tsuyoshi Inoue Diane L. Rosin Mark D. Okusa 《Journal of the American Society of Nephrology : JASN》2015,26(10):2470-2481
We showed previously that prior exposure to a modified ultrasound regimen prevents kidney ischemia-reperfusion injury (IRI) likely via the splenic cholinergic anti-inflammatory pathway (CAP) and α7 nicotinic acetylcholine receptors (α7nAChR). However, it is unclear how ultrasound stimulates the splenic CAP. Further investigating the role of the spleen in ischemic injury, we found that prior splenectomy (–7d) or chemical sympathectomy of the spleen with 6-hydroxydopamine (6OHDA; –14d) exacerbated injury after subthreshold (24-minute ischemia) IRI. 6-OHDA–induced splenic denervation also prevented ultrasound-induced protection of kidneys from moderate (26-minute ischemia) IRI. Ultrasound-induced protection required hematopoietic but not parenchymal α7nAChRs, as shown by experiments in bone marrow chimeras generated with wild-type and α7nAChR–/– mice. Ultrasound protection was associated with reduced expression of circulating and kidney-derived cytokines. However, splenocytes isolated from mice 24 hours after ultrasound treatment released more IL-6 ex vivo in response to LPS than splenocytes from sham mice. Adoptive transfer of splenocytes from ultrasound-treated (but not sham) mice to naïve mice was sufficient to protect kidneys of recipient mice from IRI. Ultrasound treatment 24 hours before cecal ligation puncture–induced sepsis was effective in reducing plasma creatinine in this model of AKI. Thus, splenocytes of ultrasound-treated mice are capable of modulating IRI in vivo, supporting our ongoing hypothesis that a modified ultrasound regimen has therapeutic potential for AKI and other inflammatory conditions. 相似文献
28.
29.
Gulcan Gok Natalie Cox Jasdeep Bajwa Dimitra Christodoulou Andrew Moody David C. Howlett 《The British journal of oral & maxillofacial surgery》2013
Hypersalivation is a common and distressing complaint in children with neuromuscular disorders such as cerebral palsy. Complications associated with severe drooling include daily changes of clothing, perioral dermatitis, dental problems, dehydration, and aspiration pneumonia, which potentially have a detrimental effect on the quality of life of the patient and carer. In this paper we update our previous work to show the potential benefits of ultrasound-guided injection of botulinum toxin A (BTX-A) into the submandibular gland and report on new patients and follow-up data on the existing group. 相似文献
30.
Abdul Moiz Hafiz MBBS MD M. Fuad Jan MBBS MD Naoyo Mori PHD Fareed Shaikh MD Jeffrey Wallach MD Tanvir Bajwa MD FACC FSCAI Suhail Allaqaband MD FACC FCCP FSCAI 《Catheterization and cardiovascular interventions》2012,79(6):929-937
Objective : We compared use of intravenous (IV) normal saline (NS) to sodium bicarbonate (NaHCO3) with or without oral N‐acetylcysteine (NAC) for prevention of contrast‐induced acute kidney injury (CI‐AKI). Background : CI‐AKI is associated with significant adverse clinical events. Use of NAC has produced variable results. Recently, intravenous hydration with NaHCO3 for CI‐AKI prophylaxis has been adopted as standard treatment for patients with stable chronic renal disease undergoing catheterization procedures. Methods : We prospectively enrolled 320 patients with baseline renal insufficiency scheduled to undergo catheterization. Patients were randomly assigned to receive either IV NS ± NAC (n = 161) or IV dextrose 5% in water containing 154 mEq/l of NaHCO3 ± NAC (n = 159). IV NS was administered at 1 ml/kg body weight for 12 hr preprocedure and 12 more hr postprocedure. IV NaHCO3 was administered at 3 ml/kg body weight for 1 hr preprocedure followed by 1 ml/kg body weight postprocedure. A 1,200 mg oral dose of NAC was given 2–12 hr preprocedure and 6–12 hr postprocedure in 50% of patients in each study arm. CI‐AKI was defined as an increase of >0.5 mg/dl or >25% above baseline creatinine. Results : Overall incidence of CI‐AKI was 10.3%. There was no significant difference in incidence among the two groups (NS ± NAC 11.8% vs. NaHCO3 ± NAC 8.8%, p = ns). Incidence of CI‐AKI increased with increasing age (p = 0.001), contrast agent use >3 ml/kg body weight (p = 0.038) and diuretic use (p = 0.005). Conclusion : Incidence of CI‐AKI was no different in the NaHCO3 group compared to NS group, and NAC did not reduce CI‐AKI in the two study arms. © 2011 Wiley Periodicals, Inc. 相似文献