全文获取类型
收费全文 | 28882篇 |
免费 | 1352篇 |
国内免费 | 227篇 |
专业分类
耳鼻咽喉 | 233篇 |
儿科学 | 698篇 |
妇产科学 | 250篇 |
基础医学 | 3525篇 |
口腔科学 | 574篇 |
临床医学 | 1759篇 |
内科学 | 7610篇 |
皮肤病学 | 506篇 |
神经病学 | 2010篇 |
特种医学 | 1156篇 |
外科学 | 5246篇 |
综合类 | 113篇 |
一般理论 | 1篇 |
预防医学 | 689篇 |
眼科学 | 429篇 |
药学 | 1826篇 |
中国医学 | 45篇 |
肿瘤学 | 3791篇 |
出版年
2023年 | 202篇 |
2022年 | 400篇 |
2021年 | 706篇 |
2020年 | 364篇 |
2019年 | 569篇 |
2018年 | 682篇 |
2017年 | 534篇 |
2016年 | 713篇 |
2015年 | 727篇 |
2014年 | 991篇 |
2013年 | 1115篇 |
2012年 | 1769篇 |
2011年 | 1959篇 |
2010年 | 1145篇 |
2009年 | 956篇 |
2008年 | 1630篇 |
2007年 | 1804篇 |
2006年 | 1805篇 |
2005年 | 1808篇 |
2004年 | 1738篇 |
2003年 | 1650篇 |
2002年 | 1619篇 |
2001年 | 432篇 |
2000年 | 394篇 |
1999年 | 421篇 |
1998年 | 389篇 |
1997年 | 330篇 |
1996年 | 301篇 |
1995年 | 244篇 |
1994年 | 235篇 |
1993年 | 209篇 |
1992年 | 291篇 |
1991年 | 245篇 |
1990年 | 239篇 |
1989年 | 256篇 |
1988年 | 219篇 |
1987年 | 183篇 |
1986年 | 163篇 |
1985年 | 133篇 |
1984年 | 106篇 |
1983年 | 90篇 |
1982年 | 59篇 |
1981年 | 56篇 |
1980年 | 44篇 |
1979年 | 68篇 |
1978年 | 58篇 |
1977年 | 55篇 |
1973年 | 36篇 |
1972年 | 46篇 |
1971年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
991.
Tsuyoshi Hamada Hideo Yasunaga Yousuke Nakai Hiroyuki Isayama Hiromasa Horiguchi Kiyohide Fushimi Kazuhiko Koike 《Journal of gastroenterology》2014,49(1):148-155
Background
Although several population-based studies have shown higher hospital volume (HV) to be associated with better outcomes in acute pancreatitis, they failed to adjust for disease severity and did not take into account the potentially non-linear relationship between HV and outcomes. Using a Japanese nationwide administrative database, this study aimed to evaluate the volume–outcome relationship in acute pancreatitis by means of statistical methods that permitted such considerations.Methods
In-hospital mortality, length of stay, and total costs for patients with acute pancreatitis were analyzed using multivariate regression models fitted with generalized estimating equations. Adjustment for severity was based on the Japanese Severity Scoring System and other patient characteristics. We used restricted cubic spline functions to examine the potential non-linear relationships between HV and outcomes.Results
In all, 17,415 eligible patients with acute pancreatitis were identified from 1,032 hospitals between 1 July 2010 and 30 September 2011. The in-hospital mortality rate was 2.6 %, and the median total costs were US $7,740 (interquartile range, 5,150–11,920). The overall and non-linear volume–outcome relationships were not significant either for in-hospital mortality or total costs. The median length of stay was 14 days (interquartile range, 10–22), and high HV was positively associated with shorter hospitalization (overall, P < 0.001; non-linear, P = 0.194).Conclusions
Despite the shorter hospitalization with higher HV, no inverse volume–outcome relationship was evident for acute pancreatitis. Further evidence is required to justify the volume-based selective referral of acute pancreatitis patients. 相似文献992.
Hiroyuki Murata Soichiro Ito Hiroyuki Kusuhara Yukihiro Nomura Toshio Taniguchi 《Journal of pharmaceutical sciences》2019,108(12):3898-3902
It is known that potent inhibition of organic-anion-transporting polypeptide (OATP)1B1 increases exposure to statins, leading to severe adverse effects. The aim of this study was to propose a parameter and its criteria in OATP1B1 inhibition assay at the early drug discovery stage to avoid compounds with the risk of statin-related adverse effects. According to drug label information, most compounds classified as “contraindicated” or “should be avoided” when administered concomitantly with statins increased their AUCs more than 4-fold. Generally, R values where R = 1 + plasma unbound fraction (fu) × maximum inhibitor concentration at the inlet to the liver/IC50 are used to evaluate the extent of clinical drug interaction. However, clinical doses and Cmax cannot be determined at the screening stage. Therefore, we estimated the correlations between change in AUC of statins concomitantly administered with OATP1B1 inhibitors and various parameters including fu/IC50. Cyclosporin A, rifampicin, and telaprevir increased the AUC of statins more than 4-fold and fu/IC50 of these compounds was >0.1 L/μmol. On the other hand, fu/IC50 of other compounds was ≤0.03 L/μmol. This study indicates that fu/IC50 is a useful parameter to avoid compounds that seriously affect statin potency through interaction with OATP1B1 at the screening stage. 相似文献
993.
994.
Kobayashi Kentaro Manabe Osamu Hirata Kenji Yamaguchi Shigeru Kobayashi Hiroyuki Terasaka Shunsuke Toyonaga Takuya Furuya Sho Magota Keiichi Kuge Yuji Kudo Kohsuke Shiga Tohru Tamaki Nagara 《European journal of nuclear medicine and molecular imaging》2020,47(8):1833-1842
European Journal of Nuclear Medicine and Molecular Imaging - 18F-fluoromisonidazole (18F-FMISO) is the most widely used positron emission tomography (PET) tracer for imaging tumor hypoxia. Previous... 相似文献
995.
Fujii Hiroyuki Tsuji Taisuke Yuba Tatsuya Tanaka Shunya Suga Yoshifumi Matsuyama Aosa Omura Ayaka Shiotsu Shinsuke Takumi Chieko Ono Seiko Horiguchi Masahito Hiraoka Noriya 《Clinical rheumatology》2020,39(11):3171-3175
Clinical Rheumatology - We treated two patients with severe respiratory failure due to coronavirus disease 2019 (COVID-19). Case 1 was a 73-year-old woman, and Case 2 was a 65-year-old-man. Neither... 相似文献
996.
997.
998.
Maho Suzukawa Nobuharu Ohshima Hiroyuki Tashimo Isao Asari Nobuyuki Kobayashi Shunsuke Shoji Shigeto Tohma Ken Ohta 《Internal medicine (Tokyo, Japan)》2020,59(22):2849
Objective Mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, is effective for treating eosinophilic severe asthma. However, there is a need for more biomarkers that can predict the patient response to mepolizumab before starting therapy. This study aimed to identify a new biomarker in the serum that is able to accurately predict the responsiveness to mepolizumab. Methods This study enrolled 11 patients who had all been diagnosed with severe eosinophilic asthma and were then administered mepolizumab every 4 weeks for at least 4 months. Blood samples were collected, and pulmonary function tests and questionnaires were administered at baseline and after 4, 8 and 16 weeks of treatment. The response to mepolizumab was then assessed based on the difference in the Asthma Quality of Life Questionnaire (AQLQ) score after 16 weeks of mepolizumab therapy compared with that at baseline. Patients with an increase in the AQLQ score of more than 0.5 were defined as responders. The cytokine levels in the blood were measured by LUMINEX 200 and ELISA. Results There were 6 responders and 5 non-responders. The responders showed a significantly lower serum level of chemokine (C-C motif) ligand 4/macrophage inflammatory protein-1β (CCL4/MIP-1β) at baseline compared to the non-responders. Receiver operating characteristic curves to distinguish responders from non-responders using the baseline serum CCL4/MIP-1β level showed a good area under the curve of 0.9. The non-responders showed a significant increase in the level of CCL4/MIP-1β after 4 weeks compared to the baseline. Conclusion A low baseline serum CCL4/MIP-1β level may be useful for predicting a good mepolizumab response in severe eosinophilic asthma. 相似文献
999.
Yusuke Satta Masaki Yamashita Yasumasa Matsuo Hirofumi Kiyokawa Yoshinori Sato Hiromu Takemura Hiroyuki Kunishima Hiroshi Yasuda Fumio Itoh 《Internal medicine (Tokyo, Japan)》2020,59(22):2811
Objective Gastrointestinal lesions of non-tuberculous mycobacteria (NTM) are regarded as opportunistic infections. A large number of positive specimens of NTM were identified in an intestinal fluid culture in the endoscopy unit and it was considered to be a pseudo-outbreak. Methods We reviewed the hospital, laboratory, and colonoscopy records of 263 consecutive patients whose intestinal fluids were analyzed for a mycobacterial culture by colonoscopy at St. Marianna University Hospital, between January 2009 and December 2018. The endoscopy reprocessing procedures were reviewed and samples of water used in the endoscopy unit were cultured. Results An intestinal fluid culture of 154 (58.6%) patients tested positive for NTM (M. intracellulare; 125 cases, M. gordonae; 14 cases, M. avium; 4 cases, M. abscessus; 3 cases, and 8 other cases). In 182 cases (69.2%), an intestinal mucosal culture was performed simultaneously with a fluid culture and tested positive for NTM in 2 cases. Next, we examined the endoscopy unit for any possible environmental contamination. NTM were detected in the tap water used to prepare the antifoaming solution in the endoscopy unit. The water faucets in the endoscopy unit were considered to be the source of the contamination of NTMs. Conclusion We observed that a large number of cases tested positive due to contaminated water that had been used in an endoscopy unit, thus leading to a pseudo-outbreak of NTM. 相似文献
1000.
Satona Tanaka Minoru Aoki Hiroyuki Ishikawa Yosuke Otake 《General thoracic and cardiovascular surgery》2014,62(6):370-375