全文获取类型
收费全文 | 28831篇 |
免费 | 1403篇 |
国内免费 | 227篇 |
专业分类
耳鼻咽喉 | 233篇 |
儿科学 | 698篇 |
妇产科学 | 250篇 |
基础医学 | 3525篇 |
口腔科学 | 574篇 |
临床医学 | 1759篇 |
内科学 | 7610篇 |
皮肤病学 | 506篇 |
神经病学 | 2010篇 |
特种医学 | 1156篇 |
外科学 | 5246篇 |
综合类 | 113篇 |
一般理论 | 1篇 |
预防医学 | 689篇 |
眼科学 | 429篇 |
药学 | 1826篇 |
中国医学 | 45篇 |
肿瘤学 | 3791篇 |
出版年
2023年 | 202篇 |
2022年 | 400篇 |
2021年 | 706篇 |
2020年 | 364篇 |
2019年 | 569篇 |
2018年 | 682篇 |
2017年 | 534篇 |
2016年 | 713篇 |
2015年 | 727篇 |
2014年 | 991篇 |
2013年 | 1115篇 |
2012年 | 1769篇 |
2011年 | 1959篇 |
2010年 | 1145篇 |
2009年 | 956篇 |
2008年 | 1630篇 |
2007年 | 1804篇 |
2006年 | 1805篇 |
2005年 | 1808篇 |
2004年 | 1738篇 |
2003年 | 1650篇 |
2002年 | 1619篇 |
2001年 | 432篇 |
2000年 | 394篇 |
1999年 | 421篇 |
1998年 | 389篇 |
1997年 | 330篇 |
1996年 | 301篇 |
1995年 | 244篇 |
1994年 | 235篇 |
1993年 | 209篇 |
1992年 | 291篇 |
1991年 | 245篇 |
1990年 | 239篇 |
1989年 | 256篇 |
1988年 | 219篇 |
1987年 | 183篇 |
1986年 | 163篇 |
1985年 | 133篇 |
1984年 | 106篇 |
1983年 | 90篇 |
1982年 | 59篇 |
1981年 | 56篇 |
1980年 | 44篇 |
1979年 | 68篇 |
1978年 | 58篇 |
1977年 | 55篇 |
1973年 | 36篇 |
1972年 | 46篇 |
1971年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
Yoshinori Itoh Yutaka Kohgo Naoki Watanabe Yuji Kanisawa Sumio Sakamaki Minoru Takahashi Yasuo Hirayama Hiroyuki Ono Takeshi Himeno Yoshiro Niitsu 《Cancer science》1991,82(11):1203-1206
Human tumor–infiltrating lymphocytes (TILs) derived from pleural or ascitic fluid were incubated with recombinant interleukin 2 and transfected with human tumor necrosis factor (TNF) a gene by the lipofection procedure. The resulting TILs secreted significant amounts of TNF in the culture supernatant and exhibited cytotoxicity against established cell lines, such as K562 and Daudi, and autologous tumor cells. The TNF gene–transfected TILs exhibited an augmented killing of autologous tumor cells. 相似文献
22.
M Tatsuta H Iishi M Baba A Nakaizumi H Uehara H Taniguchi 《International journal of cancer. Journal international du cancer》1991,47(1):54-59
The effects of sulpiride on cysteamine inhibition of gastric carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and on the BUdR labelling index of gastric mucosa were investigated in inbred Wistar rats. After 25 weeks of oral treatment with MNNG, rats received one of the following alternate-day injections: cysteamine (2 doses), cysteamine (2 doses) plus sulpiride or sulpiride. At week 52, prolonged administration of cysteamine significantly reduced the incidence of adenocarcinomas of the glandular stomach. Cysteamine at low dose had no effect on the incidence of gastric cancers, but a combination of low-dose cysteamine and sulpiride caused a significantly greater reduction in the incidence of gastric cancers. Administration of sulpiride alone had no influence on gastric carcinogenesis. The labelling index of the antral mucosa was significantly lower in rats treated with high but not low doses of cysteamine. However, a combination of low-dose cysteamine and sulpiride significantly decreased the labelling index of the antral mucosa. Our findings indicate that cysteamine suppressed gastric carcinogenesis and that sulpiride enhanced this inhibition. Because sulpiride is a dopamine antagonist, these findings also indicate that dopamine may play an important role in cysteamine inhibition of gastric carcinogenesis. 相似文献
23.
24.
Masako Nishizuka Hiroyuki Sumida† Yasuhiko Kano† Yasumasa Aral 《Journal of neuroendocrinology》1993,5(5):569-573
An examination was made of neurogenesis in the anteroventral periventricular nucleus (AVPv) of the preoptic area of the rat using bromodeoxyuridine (BrdU), a thymidine analog, and a BrdU-specific antibody. Cells in the AVPv of adult rats were labeled with the antibody when BrdU was injected into pregnant rats once during day 13 to 18 of gestation, but not during day 10 to 12 nor 19 to 20 of gestation nor on postnatal day 1, indicating that neurogenesis of the AVPv occurs during a limited period from day 13 to 18 of gestation. Next, to examine the effects of androgen on neurogenesis, BrdU was injected once on day 15 into pregnant rats that also received injections of testosterone propionate (TP). The number of BrdU-labeled cells in the AVPv was similar in control female and male fetuses and female fetuses from pregnant rats that received daily injections of TP during days 14 to 16, when fetuses were examined on day 17 of gestation. These results suggest that the neurogenesis that was recognized by labeling with BrdU was not affected by the treatment with TP. On day 21 of gestation, BrdU-labeled cells in the AVPv of control male fetuses and female fetuses that received TP during days 14 to 18 were fewer in number than those in female fetuses of the control group, whereas treatments with TP during days 14 to 16 and during days 17 to 18 did not cause any significant decrease in number of BrdU-labeled cells. These findings support the hypothesis that elimination of a population of cells, for example, by cell death as described previously, is enhanced in male fetuses and in female fetuses treated with TP repetitively. 相似文献
25.
Hiroyuki Hamakawa Hiroaki Kayahara Hiroaki Tanioka 《International journal of oral and maxillofacial surgery》1997,26(6):440-442
We describe a procedure for “chain-link” combined tissue transfer connecting the vascular pedicle of a deep circumflex iliac flap with that of a forearm flap after wide resection of the mandible. Combination of these flaps facilitated the reconstruction of the defect in both intra- and extraoral soft tissue and the mandibular bone. This method is useful when cervical recipient blood vessels are limited due to the wide resection of the primary tumor and radical neck dissection. 相似文献
26.
27.
Tsuyoshi Takeda Hiroyuki Ishida Yukio Horiuchi Yasushi Nakao Yutaka Yabe 《Journal of orthopaedic science》1997,2(6):372-377
We examined radiographs of the elbows of the pitching arms of 79 professional baseball pitchers (mean age, 25.1 years; mean
duration of professional career, 4.7 years) and noted the frequency and size of spurs, bone fragments, and intra-articular
loose bodies according to site. The influence of duration of professional baseball career on these osteoarthritic changes
was also investigated. The olecranon tip was the most frequent site of spurs (62/79; 78.5%), and fragmentation of the spur
was detected in 17 joints. The frequency of spurs was also high at the medial margin of the olecranon, the tip of the coronoid
process, the medial margin of the sigmoid notch, the medial margin of the trochlea and the olecranon fossa. In 38 subjects,
spurs were observed at the distal portion of the radial notch of the ulna. However, few pitchers had osteoarthritic changes
in the humeral capitellum or radial head. Intra-articular loose bodies were detected in 4 of 79 joints (5.1%), and bone fragments
were present below the medial humeral epicondyle in 25 of 79 joints (31.6%). Osteoarthritic changes in the elbow joint appeared
to be attributable mainly to traction stress and impingement associated with extension and valgus strain. Significant osteoarthritic
changes were often found in professional pitchers whose careers exceeded 5 years. 相似文献
28.
Tetsuo Nagatani Megumi Miyazawa Toshiko Matsuzaki Gaijiro Iemoto Shu-taku Kim Naoko Baba Kanata Miyakawa Hideaki Miyamoto Hiroshi Nakajima Yoshio Hirai 《The Journal of dermatology》1993,20(10):623-629
A 45-year-old man was referred to our department in March of 1989. Physical examination showed erythroderma, palmo-plantar hyperkeratosis, generalized lymphadenopathy, hepatosplenomegaly, and leukemic manifestation. The lymphocyte count in the peripheral blood before treatment was 1.7 × 104 cells/mm3. Atypical lymphocytes such as flower cells and lobulated cells were seen in the peripheral blood. A sample excised from a lymph node showed immunoblastic, pleomorphic T cells by a modified classification scheme of the Working Formulation. A high level of serum LDH was detected (2.1 times the upper normal limit). Anti HTLV-1 antibody was also detected in the serum. The atypical lymphocytes were positive for CD3, CD4, CD5, CD7 and HLA-DR, and negative for CD8. Thus, the clinical, pathologic and immunologic features were those of typical acute-type ATL. The patient was treated with VEPA-M for three months starting in March of 1989. Because of poor response, the patient was then treated with MACOP-B, M-FEPA, and VEPP-B for about one year from June of 1989 and has been free of disease up to the time of writing, March of 1993. 相似文献
29.
S Shishido S Baba T Ohigashi J Muraki A Hayashi M Tachibana N Deguchi S Jitsukawa M Hata H Tazaki 《Hinyokika kiyo. Acta urologica Japonica》1990,36(9):997-1001
We report the results and complications of 103 consecutive patients who underwent percutaneous removal of renal and ureteral stones. The overall clinical success rate was 80.6%. For the recent 33 cases in which UL-arm fluoroscopy was used, however, the success rate was as high as 87.9%, which was considered to be due to easier establishment of percutaneous direct access. The most common complications were bleeding (18.5%), extravasation (15.5%) and fever (9.7%). Four cases with significant bleeding required arteriography, but there were no sign of arteriovenous fistula nor pseudoaneurysms in any cases. To study renal parenchymal damage in the percutaneous procedures, plasma renin activities (PRA) were compared in 54 cases after six months. However, significant elevation of PRA did not occur in any case. 相似文献
30.
A case of indirect carotid-cavernous sinus fistula treated by combined transarterial and transvenous embolization is described. A 49-year-old woman with a right indirect carotid-cavernous sinus fistula draining solely to the right superior ophthalmic vein was treated first by transarterial embolization with polyvinyl alcohol particles. Then, by approaching through the superior ophthalmic vein from the right external jugular vein, the cavernous sinus was embolized with platinum wire using a tracker microcatheter, which resulted in marked clinical improvement. Transvenous embolization by approaching from the external jugular vein through the superior ophthalmic vein represents a promising alternative when shunted blood drains anteriorly to the superior ophthalmic vein. 相似文献