全文获取类型
收费全文 | 4460篇 |
免费 | 272篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 131篇 |
妇产科学 | 64篇 |
基础医学 | 666篇 |
口腔科学 | 111篇 |
临床医学 | 303篇 |
内科学 | 1210篇 |
皮肤病学 | 147篇 |
神经病学 | 378篇 |
特种医学 | 151篇 |
外科学 | 388篇 |
综合类 | 14篇 |
预防医学 | 196篇 |
眼科学 | 72篇 |
药学 | 355篇 |
中国医学 | 9篇 |
肿瘤学 | 518篇 |
出版年
2023年 | 36篇 |
2022年 | 67篇 |
2021年 | 130篇 |
2020年 | 89篇 |
2019年 | 116篇 |
2018年 | 138篇 |
2017年 | 106篇 |
2016年 | 123篇 |
2015年 | 105篇 |
2014年 | 150篇 |
2013年 | 172篇 |
2012年 | 327篇 |
2011年 | 320篇 |
2010年 | 181篇 |
2009年 | 125篇 |
2008年 | 243篇 |
2007年 | 229篇 |
2006年 | 224篇 |
2005年 | 232篇 |
2004年 | 216篇 |
2003年 | 238篇 |
2002年 | 208篇 |
2001年 | 91篇 |
2000年 | 103篇 |
1999年 | 87篇 |
1998年 | 55篇 |
1997年 | 22篇 |
1996年 | 22篇 |
1995年 | 23篇 |
1994年 | 19篇 |
1993年 | 18篇 |
1992年 | 46篇 |
1991年 | 53篇 |
1990年 | 34篇 |
1989年 | 59篇 |
1988年 | 41篇 |
1987年 | 54篇 |
1986年 | 44篇 |
1985年 | 36篇 |
1984年 | 25篇 |
1983年 | 17篇 |
1982年 | 8篇 |
1978年 | 14篇 |
1977年 | 10篇 |
1975年 | 8篇 |
1974年 | 7篇 |
1972年 | 7篇 |
1971年 | 7篇 |
1968年 | 7篇 |
1966年 | 7篇 |
排序方式: 共有4748条查询结果,搜索用时 15 毫秒
991.
K Kojima H Seo I Hino Y Kawasaki K Satoh M Tanabe Y Kawase K Mizukawa 《Nihon Igaku Hōshasen Gakkai zasshi. Nippon acta radiologica》1989,49(2):153-162
At the same dynamic range (DR) a constant difference of echolevels was found between two materials with different acoustic impedance in any gain-setting by the phantom study. Our retrospective study in which we compared the difference between liver-kidney echolevels with the US-findings of fatty liver indicated that the difference over 10 in echoleveled by our equipment with 3.5 MHz phased array sector scan and 42 dB DR had a possibility of the fatty infiltration of the live. In our prospective study of 1452 abdominal US-studies we found 93 cases (6.5%) with the difference over 10 in echolevel. In all these patients the difference of liver-spleen CT-numbers and liver-kidney echolevels was compared. Although the liver CT-number is normally higher than the spleen, 75 of 93 patients showed the lower liver CT-number than that of the spleen, indicating fatty infiltration of the liver. The abnormal difference of echolevels were independent from the severity of fatty infiltration. Concerning the US-findings, "bright liver" (77.4%) and "masking sign" (66.7%) were more sensitive than "vascular blurring" (44.1%) and "deep attenuation" (44.1%). But for the severe fatty infiltration with the difference over -20 H.U. between liver-spleen CT numbers, the last two findings seemed very credible. The abnormal difference between liver-kidney echolevels was most sensitive (80.7%), especially in mild cases with 0 to -19 H.U. (53 in 75 cases), and very objective than the other US-findings. 相似文献
992.
Hiroyuki Eda Kaori Fujimoto Shin-ichi Watanabe Masako Ura Ayako Hino Yutaka Tanaka Kenji Wada Hideo Ishitsuka 《Cancer chemotherapy and pharmacology》1993,32(5):333-338
The present study shows that various cytokines such as tumor necrosis factor (TNF), interleukin-1 (IL-1), and interferon- (IFN) make tumor cells much more susceptible to the cytostatic 5-deoxy-5-fluorouridine (5-dFUrd) than to 5-fluorouracil (5-FUra) and other cytostaties. These three cytokines increased the susceptibility of human cancer cell lines (COLO201, MKN45 and WiDr) but did not affect that of normal fibroblast WI38 cells. The cytokine mixture induced a 50-fold increase in the susceptibility of COLO201 to 5-dFUrd, whereas a 12-fold increase and a less than 5-fold enhancement in the susceptibility to 5-FUra and other cytostatics, respectively, were observed. The increased susceptibility would be a result of the induction of thymidine phosphorylase (TdR Pase), which is the essential enzyme for the conversion of 5-dFUrd to 5-FUra. The cytokine mixture increased TdR Pase activity by up to 47 times and greatly induced its mRNA expression in the cancer cell lines. These results suggest that the therapeutic benefit of 5-dFUrd would be improved by its use in combination with the cytokines. 相似文献
993.
994.
Masaharu Masuda MD PhD Yasuhiro Matsuda MD Hiroyuki Uematsu MD Ayako Sugino MD Hirotaka Ooka MD Satoshi Kudo MD Subaru Fujii MD Mitsutoshi Asai MD PhD Shin Okamoto MD Takayuki Ishihara MD Kiyonori Nanto MD Takuya Tsujimura MD Yosuke Hata MD Naoko Higashino MD Sho Nakao MD Toshiaki Mano MD PhD 《Journal of cardiovascular electrophysiology》2024,35(1):171-181
995.
Kazuma Kanaki Yuko Otsuka Rumi Hino Tomoko Kaburagi 《Journal of Clinical Biochemistry and Nutrition》2022,70(1):14
The study results regarding the effects of low-carbohydrate (LC) diets remain controversial; hence further research is required to assess their safety. Here, we examined whether LC diets cause skin damage in C57BL/6J mice. Six-week-old female mice (n = 20) were fed an LC (protein/fat/carbohydrate energy ratio = 35:45:20) or control diet ad libitum for eight weeks, after which their backs were shaved, and a subset of the mice were exposed to ultraviolet B radiation thrice per week. Ultraviolet B irradiation induced wrinkle formation on the skin surface, and thickening of the epidermis, which was also noticeable in the LC diet-fed mice in the absence of ultraviolet B radiation. Meanwhile, the number of epidermal melanocytes and degree of horny layer keratosis increased in the LC diet-fed mice following ultraviolet B irradiation. mRNA expression analysis of the liver and skin showed decreased levels of the antioxidant enzyme superoxide dismutase 1 following ultraviolet B irradiation only in the LC diet-fed mice. Alternatively, the expression of pro-inflammatory cytokines, tumor necrosis factor-α and interleukin-1β, increased in response to ultraviolet B radiation and LC diet intake. Hence, LC diets may adversely affect skin morphology and exacerbate the effects of ultraviolet B irradiation, which may be associated with antioxidant dysfunction. 相似文献
996.
Makiko Suga Kentaro Fukushima Tomoaki Ueda Yasuyuki Arai Shunsaku Nakagawa Yosuke Minami Jun Toda Akihisa Hino Jiro Fujita Takafumi Yokota Naoki Hosen 《Clinical Case Reports》2022,10(2)
FMS‐like tyrosine kinase 3‐internal tandem duplication (FLT3‐ITD) mutation‐positive acute myeloid leukemia (AML) has a poor prognosis. We report the first case of successful bridge therapy of novel FLT3 inhibitor, quizartinib, to umbilical cord blood stem cell transplantation for FLT3‐ITD‐positive AML‐primary induction failure patients with central nervous system involvement. 相似文献
997.
Rosa Casas Sara Castro-Barquero Francesca Crovetto Marta Larroya Ana Maria Ruiz-Len Laura Segals Ayako Nakaki Lina Youssef Leticia Benitez Francesc Casanovas-Garriga Eduard Vieta Ftima Crispi Eduard Gratacs Ramon Estruch 《Nutrients》2022,14(11)
The information available on the effects of maternal dietary habits on systemic inflammation and adverse maternal outcomes is limited. We aimed to evaluate whether Dietary Inflammatory Index (DII) score during pregnancy is associated with maternal body mass index (BMI), Mediterranean diet (MD) adherence, and perinatal outcomes. At 19–23 weeks’ gestation, 1028 pregnant women were recruited. Dietary information was assessed using a 17-item dietary score to evaluate MD adherence and a validated 151-item food frequency questionnaire. DII score was established according to 33 food and nutritional proinflammatory and anti-inflammatory items. Participants were distributed into tertiles according to the DII score, where a lower DII score (first tertile) represented an anti-inflammatory diet and the third tertile represented the more proinflammatory diet. Maternal characteristics and perinatal outcomes were collected, and newborns’ birthweight percentiles were calculated. Adjusted logistic regression models were used to assess the association of the DII score with maternal and perinatal characteristics, setting the third tertile as the reference group. Women in the third tertile showed lower adherence to MD score compared to the first tertile: median (25th to 75th percentile) 9 (7 to 11) vs. 6 (4.25 to 8), p < 0.001. The proinflammatory diet was significantly associated with a higher maternal pre-pregnancy BMI (adjusted β = 0.88; 95% CI: 0.31 to 1.45) and lower newborn’s birthweight percentile (adjusted β = −9.84th; 95% CI: −19.6 to −0.12). These data show that a proinflammatory diet profile may be associated with maternal overweight and fetal undergrowth. 相似文献
998.
Tomoyuki Kabutoya Yasushi Imai Yutaka Aoyama Shinichi Toriumi Ayako Yokota Takahiro Komori Kazuomi Kario 《Internal medicine (Tokyo, Japan)》2022,61(10):1545
A 95-year-old woman with no cardiac history presented with symptomatic complete atrioventricular block. She underwent temporary cardiac pacing via the cervical vein, but a pacing lead could not be introduced via the usual route because of a mediastinal tumor. A leadless pacemaker (Micra™; Medtronic, Minneapolis, USA) was implanted at the right ventricular septum via the right femoral vein. The procedure time was 40 minutes, with no complications noted. Over the two-year follow-up period, the threshold and impedance remained stable. The implantation of a leadless pacemaker was useful for improving the symptoms of a super-elderly woman with a mediastinal tumor. 相似文献
999.
Michio Wachi Takumi Jiroumaru Ayako Satonaka Masae Ikeya Shinichi Noguchi Mika Suzuki Yutaro Hyodo Yasumasa Oka Takamitsu Fujikawa 《Journal of Physical Therapy Science》2022,34(5):400
[Purpose] In this study, we investigated the therapeutic effects of capacitive and resistive electric transfer therapy in patients with chronic low back pain. [Participants and Methods] The study included 24 patients with chronic low back pain (12 patients each in the intervention and sham groups). Pain intensity, superficial and deep lumbar multifidus stiffness and maximum forward trunk flexion and associated activation level of the iliocostalis (thoracic and lumbar component) and lumbar multifidus muscles were measured. [Results] Post-intervention pain intensity and muscle stiffness were significantly lower than pre-intervention measurements in the intervention group. However, no between-group difference was observed in the muscle activation level at the end-point of standing trunk flexion. [Conclusion] Our findings highlight a significant therapeutic benefit of capacitive and resistive electric transfer therapy in patients with chronic low back pain and muscle stiffness. 相似文献
1000.
Yoko Taminishi-Katsuragawa Yuji Shimura Yu Inoue Yayoi Matsumura-Kimoto Taku Tsukamoto Shinsuke Mizutani Tsutomu Kobayashi Naoko Takeda-Miyata Ayako Nishimura Kojiro Takatsuka Junya Kuroda 《Internal medicine (Tokyo, Japan)》2022,61(8):1231
Myeloid sarcoma (MS) is a relatively rare manifestation of myeloid neoplasms at sites other than the bone marrow. The rarity of gastrointestinal (GI) MS is attributed to certain factors, such as misdetection due to insufficient endoscopic assessments at the initial presentation with acute myeloid leukemia (AML) as well as the difficulty of making a histologic assessment of leukemic involvement of the GI tract. We herein report a case of AML with gastric involvement and discuss the importance of screening examinations and therapies considering the location of MS and the data of cytogenetic and molecular mutation. 相似文献