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81.
Fujimura Yoshinori Yoshimoto Takanori Fujino Konatsu Nezu Ayaka Marugame Yuki Bae Jaehoon Kumazoe Motofumi Tachibana Hirofumi 《Journal of natural medicines》2023,77(2):363-369
Journal of Natural Medicines - Many patients with allergies have anxiety about taking anti-allergic medicines due to their side effects and increased medical expenses. Thus, developing functional... 相似文献
82.
Assessment of subjective intraocular forward scattering and quality of vision after posterior chamber phakic intraocular lens with a central hole (Hole ICL) implantation 下载免费PDF全文
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84.
Yu Miyahara Hideki Funahashi Ayaka HarutaTsukamoto Hiroto Hidaka Takako Fujimoto Akira Horinouchi Toshikazu Nishimori Yasushi Ishida 《Clinical Case Reports》2021,9(11)
Venlafaxine has potential as a therapeutic option for patients with depressive disorder, migraine, and pruritus unresponsive to antihistamines. 相似文献
85.
Ayaka Yoshikawa Shuzo Yoshida Yuko Kimura Nao Tokai Yohei Fujiki Takuya Kotani 《Modern rheumatology / the Japan Rheumatism Association》2018,28(2):227-234
Objectives: In this study, iguratimod (IGU) was added to rheumatoid arthritis (RA) patients inadequately responding to 24-week or longer treatment with biological disease-modifying antirheumatic drug (bDMARDs), its effectiveness was assessed, and factors contributing to remission were evaluated.Methods: RA patients who fulfilled the following criteria were included: (i) ≥?24-week of bDMARDs; (ii) 2.6?Results: DAS assessing 28 joints with ESR (DAS28-ESR) decreased significantly from 3.45?±?0.92 at baseline to 2.85?±?1.13 at 24 weeks (p?.001). Overall, 38.3% achieved clinical remission (c-remission). The total PD score decreased significantly from 8.7?±?6.1 at baseline to 5.5?±?5.0 at 24 weeks (p?.001). A lower baseline DAS28-ESR was related to c-remission after 24 weeks (p =.002). Shorter duration of disease (p =.020) was related to ultrasound remission, in addition to a lower baseline DAS28-ESR (p?.001).Conclusions: IGU add-on therapy can be a therapeutic strategy to achieve remission in RA patients inadequately responding to ≥24-week treatment with bDMARDs. 相似文献
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87.
Yousuke Gomi Liangcheng Wang Hisashi Matsushima Ayaka Kawabe Atsuko Kikugawa Akiyoshi Takagi Kenichi Kuromaki 《Taiwanese journal of obstetrics & gynecology》2019,58(6):805-807
ObjectiveTo investigate the long-term antibiotic susceptibility of group B Streptococcus (GBS) present in the vagina.Materials and methodsA population-based retrospective cohort study was performed. A total of 19,899 women who underwent vaginal swab examination between 2005 and 2017 was enrolled. Specimens were cultured on modified Drigalski agar, blood agar, and chocolate agar media. Antibiotic susceptibilities of GBS were assessed using eight antibiotics, namely penicillin-G (PC-G), cefotiam (CTM), cefditoren (CDTR), ceftriaxone (CTRX), meropenem (MEPM), chloramphenicol (CP), levofloxacin (LVFX), and azithromycin (AZM), by the broth microdilution method when GBS was positive in the culture. The main outcome was antibiotic sensitivity based on the culture results.ResultsGBS was 100% susceptible to PC-G, CTM, CTRX, CDTR, and MEPM. However, the susceptibility trend showed a considerable decrease for CP (99%–81%), LVFX (91%–70%), and AZM (87%–57%).ConclusionsOur study demonstrated a significant decrease in the antibiotic sensitivity of GBS in Japan in the past 13 years. Based on these results, current policies on antibiotic resistance of GBS in maternal and neonatal care may need to be reassessed. 相似文献
88.
Hyder Said Yasutada Akiba Kazuyuki Narimatsu Koji Maruta Ayaka Kuri Ken-ichi Iwamoto Atsukazu Kuwahara Jonathan D. Kaunitz 《Digestive diseases and sciences》2017,62(8):1944-1952
Background
Therapy with nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with enteropathy in humans and experimental animals, a cause of considerable morbidity. Unlike foregut NSAID-associated mucosal lesions, most treatments for this condition are of little efficacy. We propose that the endogenously released intestinotrophic hormone glucagon-like peptide-2 (GLP-2) prevents the development of NSAID-induced enteropathy. Since the short-chain fatty acid receptor FFA3 is expressed on enteroendocrine L cells and on enteric nerves in the gastrointestinal tract, we further hypothesized that activation of FFA3 on L cells protects the mucosa from injury via GLP-2 release with enhanced duodenal HCO3 ? secretion. We thus investigated the effects of synthetic selective FFA3 agonists with consequent GLP-2 release on NSAID-induced enteropathy.Methods
We measured duodenal HCO3 ? secretion in isoflurane-anesthetized rats in a duodenal loop perfused with the selective FFA3 agonists MQC or AR420626 (AR) while measuring released GLP-2 in the portal vein (PV). Intestinal injury was produced by indomethacin (IND, 10 mg/kg, sc) with or without MQC (1–10 mg/kg, ig) or AR (0.01–0.1 mg/kg, ig or ip) treatment.Results
Luminal perfusion with MQC or AR (0.1–10 µM) dose-dependently augmented duodenal HCO3 ? secretion accompanied by increased GLP-2 concentrations in the PV. The effect of FFA3 agonists was inhibited by co-perfusion of the selective FFA3 antagonist CF3-MQC (30 µM). AR-induced augmented HCO3 ? secretion was reduced by iv injection of the GLP-2 receptor antagonist GLP-2(3-33) (3 nmol/kg), or by pretreatment with the cystic fibrosis transmembrane conductance regulator (CFTR) inhibitor CFTRinh-172 (1 mg/kg, ip). IND-induced small intestinal ulcers were dose-dependently inhibited by intragastric administration of MQC or AR. GLP-2(3-33) (1 mg/kg, ip) or CF3-MQC (1 mg/kg, ig) reversed AR-associated reduction in IND-induced enteropathy. In contrast, ip injection of AR had no effect on enteropathy.Conclusion
These results suggest that luminal FFA3 activation enhances mucosal defenses and prevents NSAID-induced enteropathy via the GLP-2 pathway. The selective FFA3 agonist may be a potential therapeutic candidate for NSAID-induced enteropathy.89.
Yukihiro Ohno Junta Imaki Yukari Mae Tsuyoshi Takahashi Ayaka Tatara 《Neuropharmacology》2011,60(2-3):201-208
Previous studies showed that 5-HT1A and 5-HT2 receptors play an important role in controlling the extrapyramidal motor disorders. However, the functions of other 5-HT receptor subtypes remain elusive. To elucidate the role of 5-HT receptors, specifically of 5-HT3~5-HT7 subtypes, in modifying antipsychotic- induced extrapyramidal side effects (EPS), we studied the effects of the 5-HT stimulant 5-hydroxytryptophan (5-HTP) and various 5-HT receptor antagonists on haloperidol (HAL)-induced bradykinesia and catalepsy in mice and rats. Pretreatment of mice with 5-HTP (25–100 mg/kg, i.p.) dose-dependently enhanced HAL (0.3 mg/kg, i.p.)-induced bradykinesia and catalepsy. The potentiation of HAL-induced EPS by 5-HTP (50 mg/kg, i.p.) was significantly inhibited by ritanserin (5-HT2 antagonist, 0.3-3 mg/kg, i.p.), ondansetron (5-HT3 antagonist, 0.1–1 mg/kg, i.p.), or SB-258585 (5-HT6 antagonist, 1–10 mg/kg, i.p.) in a dose-dependent manner. However, neither WAY-100135 (5-HT1A antagonist, 1–10 mg/kg, i.p.), GR-125487 (5-HT4 antagonist, 1–10 mg/kg, i.p.), SB-699551 (5-HT5A antagonist, 1–10 mg/kg, i.p.) nor SB-269970 (5-HT7 antagonist, 1–10 mg/kg, i.p.) reduced the 5-HTP and HAL-induced bradykinesia or catalepsy. In addition, both ondansetron (0.1–1 mg/kg, i.p.) and SB-258585 (3 and 10 mg/kg, i.p.) also alleviated bradykinesia and catalepsy induced by HAL (0.5 mg/kg, i.p.) alone in mice. Furthermore, bilateral microinjection of ondansetron (5 μg (13.7 nmol) per side) or SB-258585 (5 μg (8.92 nmol) per side) into the dorsolateral striatum (dlST) attenuated haloperidol-induced catalepsy in rats. These results suggest that serotonergic stimulation augments extrapyramidal motor disorders by activating the striatal 5-HT3 and 5-HT6 receptors and the antagonism of these receptors effectively alleviates antipsychotic-induced EPS. 相似文献
90.
Iwatsuki-Horimoto K Horimoto T Tamura D Kiso M Kawakami E Hatakeyama S Ebihara Y Koibuchi T Fujii T Takahashi K Shimojima M Sakai-Tagawa Y Ito M Sakabe S Iwasa A Takahashi K Ishii T Gorai T Tsuji K Iwamoto A Kawaoka Y 《Clinical and Vaccine Immunology : CVI》2011,18(5):860-866
Since its emergence, the 2009 pandemic H1N1 virus has spread rapidly throughout the world. Previously, we reported that most individuals born after 1920 do not have cross-reactive virus-neutralizing antibodies against pandemic (H1N1) 2009 virus, indicating that they were immunologically naïve to the pandemic virus prior to its emergence. This finding provided us with an excellent opportunity for a seroepidemiological investigation of the transmission mode of the pandemic virus in the community. To gain insight into its transmission within communities, we performed a serosurvey for pandemic virus infection with schoolchildren at an elementary school in Tokyo, Japan, and their parents. We observed a high prevalence of neutralizing antibodies to the pandemic virus in the children at this school, although the percentage of children positive for the neutralizing antibodies varied among classrooms. While a much lower prevalence was observed among parents, seropositivity of the parents correlated with that of their schoolchildren. Moreover, many adults appeared to have experienced asymptomatic infection with the pandemic virus. These data suggest that the pandemic virus was readily transmitted among schoolchildren in elementary schools and that it was also transmitted from schoolchildren to their parents. 相似文献