全文获取类型
收费全文 | 16460篇 |
免费 | 833篇 |
国内免费 | 179篇 |
专业分类
耳鼻咽喉 | 134篇 |
儿科学 | 309篇 |
妇产科学 | 151篇 |
基础医学 | 1867篇 |
口腔科学 | 256篇 |
临床医学 | 958篇 |
内科学 | 5286篇 |
皮肤病学 | 372篇 |
神经病学 | 996篇 |
特种医学 | 611篇 |
外科学 | 2776篇 |
综合类 | 65篇 |
一般理论 | 3篇 |
预防医学 | 328篇 |
眼科学 | 433篇 |
药学 | 921篇 |
中国医学 | 37篇 |
肿瘤学 | 1969篇 |
出版年
2024年 | 23篇 |
2023年 | 160篇 |
2022年 | 295篇 |
2021年 | 535篇 |
2020年 | 306篇 |
2019年 | 407篇 |
2018年 | 425篇 |
2017年 | 348篇 |
2016年 | 421篇 |
2015年 | 448篇 |
2014年 | 605篇 |
2013年 | 706篇 |
2012年 | 1205篇 |
2011年 | 1327篇 |
2010年 | 776篇 |
2009年 | 581篇 |
2008年 | 1012篇 |
2007年 | 1159篇 |
2006年 | 1077篇 |
2005年 | 1068篇 |
2004年 | 973篇 |
2003年 | 902篇 |
2002年 | 931篇 |
2001年 | 164篇 |
2000年 | 122篇 |
1999年 | 146篇 |
1998年 | 183篇 |
1997年 | 176篇 |
1996年 | 150篇 |
1995年 | 120篇 |
1994年 | 99篇 |
1993年 | 98篇 |
1992年 | 66篇 |
1991年 | 68篇 |
1990年 | 63篇 |
1989年 | 63篇 |
1988年 | 28篇 |
1987年 | 30篇 |
1986年 | 17篇 |
1985年 | 20篇 |
1984年 | 23篇 |
1983年 | 14篇 |
1982年 | 18篇 |
1981年 | 19篇 |
1980年 | 16篇 |
1979年 | 10篇 |
1977年 | 10篇 |
1976年 | 8篇 |
1975年 | 8篇 |
1971年 | 6篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
151.
Fang Yan Shu-Yan Dai Nasima Akther Atsushi Kuno Toshihiro Yanagihara Toshiyuki Hata 《International journal of gynaecology and obstetrics》2006,94(2):108-113
OBJECTIVE: To evaluate the characteristic patterns of facial expression in fetuses aged from 28 to 34 weeks using 4-dimensional (4-D) ultrasonography. METHODS: The faces of 10 healthy fetuses aged from 28 to 34 weeks were recorded continuously for 15 min with a 4-D ultrasonographic machine performing up to 25 frames per second. The occurrence rates of blinking, mouthing, yawning, tongue expulsion, smiling, scowling, and sucking were evaluated. RESULTS: Mouthing was the most frequent facial expression (median, 6.5; range, 2-19) whereas the least frequent were scowling (median, 1; range, 0-9) and sucking (median, 1; range, 0-2). Mouthing was evident in all fetuses and significantly more frequent than any other movement (P<.05). Yawning (median, 3; range, 0-6), smiling (median, 2; range, 0-9), and blinking (median, 1.5; range, 0-6) were observed in most cases. Tongue expulsion (median, 1.5; range, 0-5), scowling, and sucking were each observed in 6 cases. CONCLUSION: 4-D sonography provides a means of evaluating fetal facial expression early in the third trimester. It may be a key to predicting fetal brain function and well-being and an important modality in future fetal neurophysiologic research. 相似文献
152.
Atsushi Yoshida Takashi Sugiyama Tsutomu Tabata Toshiharu Okugawa Norimasa Sagawa 《The Ultrasound Review of Obstetrics & Gynecology》2006,6(3):109-114
The usefulness of the vascular ultrasound in the field of obstetrics is now well recognized. Intima-media thickness (IMT) and elastic property of the common carotid artery are affected by pregnancy and vary with complications. Flow-mediated vasodilation (FMD) of the brachial artery reflects the vascular endothelial function and is reported to be useful in the management of complicated pregnancy, especially pre-eclampsia. For the screening of deep vein thrombosis of the lower extremities in the perinatal period, compression ultrasonography (CUS) is useful. 相似文献
153.
Keiji Inoue Takashi Karashima Satoshi Fukata Asuka Nomura Chiaki Kawada Atsushi Kurabayashi Mutsuo Furihata Yuji Ohtsuki Taro Shuin 《Clinical cancer research》2005,11(18):6669-6677
PURPOSE: Transitional cell carcinoma (TCC) of the urinary tract is a chemosensitive tumor. Most deaths from TCC of the urinary tract are caused by metastasis, which is resistant to conventional chemotherapy. Frequent sites of metastases from TCC of the urinary tract are regional lymph nodes, liver, lung, and bone. Of these distant metastases, bone metastasis is consistently resistant to cisplatin-based conventional chemotherapy. Therefore, in this study, we investigated whether or not a newly developed minodronate, YM529, could prevent osteolytic bone metastasis of human TCC and also enhance the effect of docetaxel in a bone tumor model of athymic nude mice. EXPERIMENTAL DESIGN: In the present study, we evaluated the effect of in vitro treatment with minodronate and/or docetaxel on the proliferation by cell count, the induction of apoptosis by terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) assay, and the biological activity of osteoclast by pit formation assay in human bladder cancer cell line, UMUC-14, and mouse osteoclast cells. In vivo, we examined the effect of minodronate in a bone tumor model of athymic nude mice, in which the percutaneous intraosseal injection in the tibia of UMUC-14, leads to osteolytic bone tumor, as a bone metastasis model. To examine whether or not minodronate could inhibit tumorigenicity and enhance the effect of the chemotherapeutic agent, docetaxel, we gave minodronate i.p. and/or docetaxel i.p. to nude mice 3 days after an intraosseal tumor implantation. Moreover, proliferation and the induction of apoptosis of cancer cells and osteoclasts in bone tumors were determined by immunohistochemistry and the TUNEL assay. RESULTS: In vitro: In vitro treatment with docetaxel inhibited proliferation and resorption pit-forming activity and induced apoptosis of mouse osteoclast cells and UMUC-14 cells. In vitro treatment with minodronate inhibited proliferation and activity and induced apoptosis of mouse osteoclast cells but not UMUC-14 cells. The treatment with minodronate enhanced the inhibition of proliferation and activity by docetaxel in osteoclasts. In vivo: In vivo combination therapy with docetaxel and minodronate significantly reduced the tumor incidence compared with the control (P < 0.05) and also growth of intraossal TCC in athymic nude mice compared with the control (P < 0.001), single therapy with docetaxel (P < 0.01), and minodronate (P < 0.05). Drug-induced body weight loss was not significantly different in any treatment group. Therapy with minodronate significantly enhanced inhibition of proliferation by docetaxel in osteoclasts of bone tumors compared with the control (P < 0.01), single therapy with docetaxel (P < 0.01), and minodronate (P < 0.05). CONCLUSIONS: These studies indicate that combination therapy with minodronate and docetaxel may be beneficial in patients with bone metastasis of human TCC in the urinary tract. 相似文献
154.
Hiroya Takeuchi Ken Futamata Arafumi Maeshima Shigemichi Hirose Atsushi Shimada Yoshiki Kawaguchi Jo Tokuyama Koji Osumi Shinya Kishi Takashi Hojo Shiei Kim Norihito Wada Takashi Oishi Yoh Isobe Shunji Ikeuchi Kiyoshi Kubochi Sumio Matsumoto 《Journal of gastrointestinal cancer》2005,36(2):99-104
We report a very rare case of primary gastric small cell carcinoma (GSCC) that was accompanied with gastric tubular adenocarcinoma. A male in his 60s had an elevated tumor with a central ulceration in the middle stomach. The patient underwent a distal gastrectomy with lymph node dissection. The pathological examination showed two separated lesions of the stomach, which contained the components of primary GSCC and primary gastric tubular adenocarcinoma. Immunohistochemical (IHC) examination demonstrated that the tumor cells in the small cell carcinoma stained positive for synaptophysin, chromogranin A, and neural cell adhesion molecule (NCAM). GSCC cells and adenocarcinoma cells independently metastasized to each regional lymph node. Further studies on the biological behavior of individual tumors may allow the development of new treatment strategies for GSCC. 相似文献
155.
Tomohiro Kaneko Sakiko Miyazaki Takuma Koike Azusa Murata Ryoko Morimoto Kuniaki Hirose Kazuhisa Takamura Daisuke Endo Atsushi Amano Tohru Minamino 《Internal medicine (Tokyo, Japan)》2022,61(9):1367
Atypical Shone''s complex is a rare congenital anomaly involving a left-sided obstructive lesion of two or three cardiovascular levels. A 70-year-old man with dyspnea on exertion was diagnosed with severe aortic stenosis (AS) with a bicuspid valve, complicated by severe aortic coarctation (CoA) and a double-orifice mitral valve. He underwent surgery for AS and CoA in one session. It is important to search for complicated malformations, even in cases of bicuspid aortic valve found in old age. 相似文献
156.
Kubota Y Yano Y Seki S Takada K Sakuma M Morimoto T Akaike A Hiraide A 《American journal of pharmaceutical education》2011,75(3):43
Objective
To determine the value of using the Roter Interaction Analysis System during objective structured clinical examinations (OSCEs) to assess pharmacy students'' communication competence.Methods
As pharmacy students completed a clinical OSCE involving an interview with a simulated patient, 3 experts used a global rating scale to assess students'' overall performance in the interview, and both the student''s and patient''s languages were coded using the Roter Interaction Analysis System (RIAS). The coders recorded the number of utterances (ie, units of spoken language) in each RIAS category. Correlations between the raters'' scores and the number and types of utterances were examined.Results
There was a significant correlation between students'' global rating scores on the OSCE and the number of utterances in the RIAS socio-emotional category but not the RIAS business category.Conclusions
The RIAS proved to be a useful tool for assessing the socio-emotional aspect of students'' interview skills. 相似文献157.
T‐cell‐rich HLA‐haploidentical hematopoietic stem cell transplantation for relapsed/refractory pediatric Philadelphia chromosome‐positive acute lymphoblastic leukemia without posttransplant tyrosine kinase inhibitor therapy 下载免费PDF全文
Hideki Sano Kazuhiro Mochizuki Mitsuko Akaihata Shogo Kobayashi Hitoshi Ohto Atsushi Kikuta 《Pediatric blood & cancer》2017,64(3)
Intensive chemotherapy with tyrosine kinase inhibitor (TKI) improves the prognosis of patients with Philadelphia chromosome‐positive acute lymphoblastic leukemia (Ph‐ALL). However, the prognosis of cases of relapsed or refractory Ph‐ALL remains poor. Here, we aimed to assess the efficacy of T‐cell‐rich HLA‐haploidentical hematopoietic stem cell transplantation (TCR‐haplo‐HSCT) in eight patients with relapsed or refractory pediatric Ph‐ALL. Transplant‐related mortality was observed in two patients. All patients discontinued TKI after receiving TCR‐haplo‐HSCT. The 3‐year probability of overall survival and event‐free survival was 75.0 and 62.5%, respectively. These results indicate the efficacy of TCR‐haplo‐HSCT for relapsed/refractory pediatric Ph‐ALL. 相似文献
158.
Izumi Nishimura Atsushi Oshima Kazumoto Shibuya Takashi Mitani Tadashi Negishi 《Regulatory toxicology and pharmacology : RTP》2012
The use of intermediate frequency (IF) magnetic fields (MFs) in occupational equipment and domestic appliances, such as inductive heating cookers, is increasing. The WHO indicated a lack of scientific evidence needed to assess the health risk of exposure to IF MFs. Male and female rats (24/group) were exposed to a 20 kHz, 0.2 mT(rms) or 60 kHz, 0.1 mT(rms) sinusoidal MF for 22 h/day from 14 days prior to and during mating. Copulated females were exposed until gestation day 7 and sacrificed thereafter. Mated males were sacrificed to examine MF exposure effects on spermatogenesis. Reproductive examinations were blinded, and experiments were duplicated per frequency to ensure reproducibility. No statistically significant, exposure-related changes were found in the estrous cycle, copulation and fertility indices, numbers of corpora lutea and implantation sites, or pre- and postimplantation loss. No reproducible changes were observed in sperm count, motility, or morphological abnormality, or in the weights of testes and epididymides after MF exposure. No significant abnormalities were observed in gross pathology or histopathology of the uterus, ovary, testis, and epididymis in the MF- or sham-exposed groups. MF exposure during the preimplantation period was not toxic to fertility or early embryogenesis under the experimental conditions. 相似文献
159.
Katsuhiro Yamasaki Takaomi Tagami Masami Kawaguchi Masahiro Okihashi Satoshi Takatori Yoshikazu Sakagami Setsuko Sekita Motoyoshi Satake 《Journal of natural medicines》2009,63(4):451-458
Simple and rapid analysis of aristolochic acid (AA) in crude drugs and Kampo extracts using a solid-phase extraction method
and HPLC-PDA analysis was investigated. Extraction of AA from samples was accomplished by adding methanol containing 1% ammonia.
The addition of ammonia ionized the AA of acidic substances so that they adhered to an acrylamide copolymer of a strong anion
exchange resin (Sep-Pak QMA) coupled to diol silica easily. Furthermore, a mixture of acetonitrile–water–phosphoric acid (75:25:2,
v/v) was effective in isolating AA from its carrier. Since almost all interfering peaks originating from contaminants in crude
drugs and Kampo extract formulations could be removed, a satisfactory HPLC chromatogram of AA was obtained. A good result
was also obtained when Aristolochiaceae and crude drugs containing AA were tested. Particularly in the case of the medicinal
parts of Asarum, several interfering peaks and a ghost peak detected near the AA peak were eliminated. The AA contents of two Kampo extract
formulations, tokishigyakukagoshuyushokyoto and ryutanshakanto, were calculated by HPLC analysis. The AA content (the sum
of AA-I and AA-II) was 1.25–6.13 mg per daily dose. From an additional recovery experiment for Kampo formulations, high recovery
rates of AA were obtained. Neither LC/MS nor special instrumentation was necessary. Our results suggest that this simple,
quick, and sensitive analytical method to detect AA in crude drugs and Kampo extract formulations would be valuable in safety
inspections of AA in crude drugs and their products. 相似文献
160.
Fukumoto A Kim YP Matsumoto A Takahashi Y Shiomi K Tomoda H Omura S 《The Journal of antibiotics》2008,61(1):1-6
Cyslabdan, a new potentiator of imipenem activity against methicillin-resistant Staphylococcus aureus, was isolated from the culture broth of Streptomyces sp. K04-0144 by Diaion HP-20 and ODS column chromatographies and preparative HPLC. The structure of cyslabdan was elucidated by spectroscopic analyses including NMR. The compound has a labdane-type diterpene skeleton connecting with an N-acetylcysteine via thioether linkage. 相似文献