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101.
Health promotion (HP) amongst older people is an increasingly prominent policy concern for governments. The development of an evidence-base and the advocacy of effective interventions in the light of this act as legitimation tools for the overall HP phenomenon – assisting the growth of state and non-state funding for public health initiatives for older people. In structuring decision-making as to which individual projects/initiatives receive funding, frameworks for acknowledging efficacy impact on formats of HP work both positively and negatively. Drawing on recent research across the EU and focusing on the specific national contexts of Austria and England, this comparative policy analysis triangulates best-practice modelling, evaluation data and interviews with project coordinators to explore how policy contexts impact on the nature and format of HP interventions. Amidst a developing awareness of what effective practice looks like, successful HP initiatives must advocate their legitimacy within narrow rules of quality, where measurable outcomes have become the keys which unlock financial resources. Findings across both countries suggest that this instrumentalisation of legitimation, driven by economic pressures and bureaucratic generalisability, threatens the rationality of HP. From a Habermasian perspective, tensions emerge between projects’ remaining reflexive towards processes and their need to articulate the ‘success’ of the interventions in a language of outcomes. Over time, in an era where resources are increasingly scarce and competition over these intensifies, a danger exists whereby the instrumentality of HP begins to separate from, and impinge upon, the capacity for projects to think and act holistically. 相似文献
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Lena Aléx Anne Hammarström Astrid Norberg Berit Lundman 《Health care for women international》2013,34(10):873-892
The aim of this part of the Umeå 85+ Study was to explore how indigenous women narrate their lives and their experience of being old as Sami women. Interviews with 9 old Sami women were analyzed using grounded theory. The categories identified were “reindeer as the basis of life,” “longing for significant Sami values,” “feeling valued as a Sami woman,” and “changing for survival;” these evolved into the core category: “balancing within various discourses—the art of being old and living as a Sami woman.” Knowing how to balance provided the ability to make use of available opportunities. 相似文献
104.
Ingegerd Hildingsson Annika Karlström Astrid Nystedt 《Sexual & Reproductive HealthCare》2013,4(1):3-8
ObjectiveAn instrumental vaginal birth is known to affect women’s birth experience, few studies have explored the fathers’ experiences of attending such a birth. The aim of this study is to compare birth outcome and parents’ feelings in parents with instrumental vaginal birth or a spontaneous vaginal birth.MethodsA regional survey was conducted of 936 mothers and 827 fathers recruited in mid-pregnancy and followed up 2 months after birth. Data was collected by questionnaires. Crude and adjusted odds ratios with a 95% confidence interval were used in the analysis.ResultsThe prevalence for instrumental vaginal birth was 9%. Prolonged labour (OR 8.3; 95% CI 5.0–13.9), augmentation with synthetic oxytocin (OR 5.1; 2.9–8.9), and birth complications (OR 2.5; 1.5–2.6) were more common in the instrumental vaginal group. An instrumental vaginal birth was associated with a negative birth experience for mothers (OR 3.2; 1.3–8.1) and fathers (OR 5.2; 1.2–21.5). Mothers who had an instrumental vaginal birth were more likely to report feelings that the baby would be damaged during birth (OR 3.0; 1.7–5.5) and that the birth experience made them decide not to have any more children (OR 3.4; 1.1–10.7). Fathers reported a near-panic feeling when attending an instrumental vaginal birth (OR 5.2; 1.7–15.5).ConclusionAn instrumental vaginal birth was correlated with longer and more complicated births, epidurals and oxytocin augmentation. It affected the birth outcome and parents’ feelings and was associated with future reproductive thoughts and a negative birth experience. 相似文献
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Katharine Bray-French Katharina Hartman Guido Steiner Céline Marban-Doran Juliana Bessa Neil Campbell Meret Martin-Facklam Kay-Gunnar Stubenrauch Corinne Solier Thomas Singer Axel Ducret 《Journal of pharmaceutical sciences》2021,110(7):2575-2584
Biotherapeutics have revolutionized our ability to treat life-threatening diseases. Despite clinical success, the use of biotherapeutics has sometimes been limited by the immune response mounted against them in the form of anti-drug antibodies (ADAs). The multifactorial nature of immunogenicity has prevented a standardized approach for assessing this and each of the assessment methods developed so far does not exhibit high enough reliability to be used alone, due to limited predictiveness. This prompted the Roche Pharma Research and Early Development (pRED) Immunogenicity Working Group to establish an internal preclinical immunogenicity toolbox of in vitro/in vivo approaches and accompanying guidelines for a harmonized assessment and management of immunogenicity in early development. In this article, the complex factors influencing immunogenicity and their associated clinical ramifications are discussed to highlight the importance of an end-to-end approach conducted from lead optimization to clinical candidate selection. We then examine the impact of the resulting lead candidate categorization on the design and implementation of a multi-tiered ADA/immunogenicity assay strategy prior to phase I (entry into human) through early clinical development. Ultimately, the Immunogenicity Toolbox ensures that Roche pRED teams are equipped to address immunogenicity in a standardized manner, paving the way for lifesaving products with improved safety and efficacy. 相似文献
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Caroline M. Heugten van Joostkker Betto G.elman Fieneke C. De Stehmann-Saris Astrid Kinebanian 《The Clinical neuropsychologist》2013,27(2):182-192
The internal consistency and the diagnostic value of a test for apraxia in patients having had a stroke are presented. Results indicate that the items of the test form a strong and consistent scale: Cronbach's alpha as well as the results of a Mokken scale analysis present good reliability and good scalability. The diagnostic value of the test was determined by comparison of test results in three groups of patients: 44 stroke patients with apraxia (patients), 35 stroke patients without apraxia (patient controls), and 50 healthy nursing home residents with no history of stroke (normal controls). The diagnostic value is expressed by means of the sensitivity and specificity and the predictive value of the test. In addition, Receiver Operator Characteristics (ROC) curves are presented. The sensitivity and specificity of the apraxia test appear to be good: all values are higher than 80%. The test also has high predictive value. The ROC curves illustrate that the test is sufficiently discriminative to allow a differentiation between persons with apraxia and persons without apraxia. 相似文献
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