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61.
Astrid Godron Jér?me Harambat Valérie Boccio Anne Mensire Adrien May Claire Rigothier Lionel Couzi Benoit Barrou Michel Godin Dominique Chauveau Stanislas Faguer Marion Vallet Pierre Cochat Philippe Eckart Geneviève Guest Vincent Guigonis Pascal Houillier Anne Blanchard Xavier Jeunemaitre Rosa Vargas-Poussou 《Clinical journal of the American Society of Nephrology》2012,7(5):801-809
62.
Janne L. Gjerde Guri Rortveit Mulu Muleta Astrid Blystad 《International urogynecology journal》2013,24(6):953-958
Introduction and hypothesis
The aim of this study was to gain in-depth knowledge of women suffering from urinary incontinence (UI) in rural and semiurban settings in Ethiopia.Methods
A qualitative study based on semistructured in-depth interviews with 26 informants, 18 of whom were women experiencing the symptom of urinary leakage. The study was conducted in the Amhara Region of northwest Ethiopia and was part of the Dabat Incontinence and Prolapse (DABINCOP) study.Results
Limited access to water, soap, pads, and spare clothes characterized daily management of the symptom. The consequences for marital relationships and social life were of great concern to the informants. Shame, embarrassment, and fear of being discriminated against led to huge efforts to hide the leakage. Among informants who were not able to hide it, humiliating comments and discriminatory behavior were commonly experienced, sometimes leading to divorce and self-isolation. Women who disclosed their symptom usually had a person who supported them. Women with UI regarded it as unnatural and uncommon. Most took no action to improve the situation, as they saw no options for help.Conclusions
Several circumstances limited the opportunities available to women to keep themselves clean, disclose the problem to others, and access health information and health-care facilities. In order to understand how women in this setting practically handled, perceived, and experienced living with UI, it was essential to address contextualized and sociocultural dimensions related to the symptom. 相似文献63.
Verena Tenten Sylvia Menzel Uta Kunter Eva-Maria Sicking Claudia R. C. van Roeyen Silja K. Sanden Michaela Kaldenbach Peter Boor Astrid Fuss Sandra Uhlig Regina Lanzmich Brigith Willemsen Henry Dijkman Martin Grepl Klemens Wild Wilhelm Kriz Bart Smeets Jürgen Floege Marcus J. Moeller 《Journal of the American Society of Nephrology : JASN》2013,24(12):1966-1980
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Inhibition of CaMKII Attenuates Progressing Disruption of Ca2+ Homeostasis Upon Left Ventricular Assist Device Implantation in Human Heart Failure 下载免费PDF全文
Thomas H. Fischer Astrid Kleinwächter Jonas Herting Jörg Eiringhaus Nico Hartmann André Renner Jan Gummert Axel Haverich Jan D. Schmitto Samuel Sossalla 《Artificial organs》2016,40(8):719-726
In heart failure, left ventricular assist device (LVAD) implantation is performed to ensure sufficient cardiac output. Whereas some patients are subsequently weaned from LVAD support, other patients still need heart transplantation. To elucidate underlying mechanisms, we assessed the arrhythmogenic SR‐Ca2+ leak at the time of LVAD implantation (HF‐Im) and heart transplantation (HF‐Tx) and evaluated the effects of CaMKII‐inhibition. Human left‐ventricular cardiomyocytes were isolated, paced at 1 Hz for 10 beats to ensure SR‐Ca2+ loading and scanned for diastolic Ca2+ sparks (confocal microscopy). In HF‐Im, the high diastolic spark frequency (CaSpF) of 0.76 ± 0.12 × 100 μm?1 × s?1 could be reduced to 0.48 ± 0.10 × 100 μm?1 × s?1 by CaMKII inhibition (AIP, 1 μM). The amplitude of Ca2+ sparks, width, and length was not significantly altered. In sum, CaMKII inhibition yielded a clear tendency toward a reduction of the SR‐Ca2+ leak (n cells/patients = 76/6 vs. 108/6, P = 0.08). In HF‐Tx, we detected an even higher CaSpF of 1.00 ± 0.10 100 μm?1 × s?1 and a higher SR‐Ca2+ leak compared with HF‐Im (increase by 81 ± 33%, n cells/patients = 156/7 vs. 130/7, P < 0.05), which fits to the further decreased LV function. Here, CaMKII inhibition likewise reduced CaSpF (0.35 ± 0.09 100 μm?1 × s?1, P = 0.06) and significantly reduced spark duration (n sparks/patients = 58/3 vs. 159/3, P < 0.05). Conclusively, the SR‐Ca2+ leak was reduced by 69 ± 12% in HF‐Tx upon CaMKII inhibition (n cells/patients = 53/3 vs. 91/3, P < 0.05). These data show that the SR‐Ca2+ leak correlates with the development of LV function after LVAD implantation and may represent an important pathomechanism. The fact that CaMKII inhibition reduces the SR‐Ca2+ leak in HF‐Tx suggests that CaMKII inhibition may be a promising option to beneficially influence clinical course after LVAD implantation. 相似文献
69.
Delayed graft function is an important medical problem after renal transplantation. It occurs in approximately 30% of cases, and is not only associated with more prolonged and complicated hospitalisation, but also with earlier graft loss on the long-term. Delayed graft function is the consequence of acute tubular necrosis caused by ischaemia-reperfusion injury, with insufficiently opposed toxic effects of reactive oxygen species and insufficient ATP regeneration. An optimal tissue thiamine status is pivotal for scavenging of reactive oxygen species and regeneration of ATP. There are several reasons to suppose that tissue thiamine availability is suboptimal in donor kidneys prior to reperfusion in transplantation. These reasons include a high prevalence of untreated thiamine deficiency at admission of donors to intensive care units, quick exhaustion of body thiamine stores during periods of non-feeding or inappropriate feeding during hospital stays of donors, and loss of the water-soluble vitamin into water-based organ preservation solutions. We therefore hypothesize that a suboptimal tissue thiamine status is a cause of delayed graft function after renal transplantation, and that it can be prevented with thiamine supplementation. 相似文献
70.
Lécuyer H Audibert J Bobigny A Eckert C Jannière-Nartey C Buu-Hoï A Mainardi JL Podglajen I 《Journal of clinical microbiology》2007,45(10):3474-3475
We report a case of non-ventilator-associated nosocomial pneumonia and septicemia due to Dolosigranulum pigrum, a rare gram-positive opportunistic pathogen. The organism was isolated from bronchoalveolar lavage fluid and blood of a debilitated patient. D. pigrum was identified after 16S rRNA gene sequencing. 相似文献