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21.
Fine-needle aspiration biopsy findings in three cases of chromophobe cell carcinoma are described and correlated with histologic and ultrastructural observations. In addition, comparisons are made with three cases each of oncocytoma and granular cell carcinoma. The cells in aspiration smears from chromophobe cell carcinoma closely correlated with histologic pattern of three cell types which were not present in oncocytomas and granular cell carcinomas. These cells had prominent cell borders, and their cytoplasm was either opaque and granular (type I) or variably translucent and reticular (type II and III). Ultrastructurally, the translucent areas within the cytoplasm contained large numbers of microvesicles which were unique to chromophobe cell carcinoma and were not seen in other neoplasms. Fine-needle aspiration may be used to diagnose chromophobe cell carcinoma and distinguish it from other related renal neoplasms. © 1995 Wiley-Liss, Inc. 相似文献
22.
Salama SA Au WW Hunter GC Sheahan RG Badary OA Abdel-Naim AB Hamada FM 《Environmental and molecular mutagenesis》2002,40(3):153-160
Atherosclerosis (AR) is the leading cause of morbidity and mortality in the US and cigarette smoking is a major contributing factor to the disease. Like cigarette smoking in lung cancer, genetic susceptibility may be an important factor in determining who is more likely to develop AR. However, the current emphasis has been on susceptibility based on altered cardiovascular homeostasis. In this investigation, we studied 120 AR patients and 90 matched controls to elucidate the association between polymorphisms in some metabolizing genes (GSTM1, GSTT1, CYP2E1, mEH, PON1, and MPO) and susceptibility to AR. We found that the GSTT1 null allele and the fast allele of mEH(*) (exon 4) are associated with risk for AR. Furthermore, the combined genotypes GSTM1 null/ CYP2E1(*)5B, GSTM1 null/mEH YY, and GSTT1 null/mEH YY are significantly associated with susceptibility to AR (OR = 15.42, 95% CI = 1.33-77.93, P = 0.021; OR = 3.48, 95% CI = 1.63-8.04, P = 0.0008; OR = 3.4; 95% CI = 0.99-17.38, P = 0.05; respectively). We have also conducted cytogenetic analysis to elucidate if induction of chromosome aberrations (CAs) is a biomarker of AR susceptibility. We found that among cigarette smokers (AR patients and smoker controls), individuals having the GSTM1 null allele had a significantly higher frequency of CAs compared to those with the normal allele (P < 0.05). This association was not found among nonsmokers. In addition, individuals who had inherited the CYP2E1(*)5B allele exhibited a significantly higher CA frequency (8.0 +/- 0.82) compared to those with the CYP2E1 wild-type genotype (4.31 +/- 0.35). Since the analysis of genetic susceptibility factors is still in its infancy, our study may stimulate additional investigations to understand the roles of genetic susceptibility and cigarette smoking in AR. 相似文献
23.
Abo-Ali Ehab A. Al-Ghanmi Amal Hadad Hajar Etaiwi Jumanah Bhutta Kainat Hadad Najlaa Almilaibary Abdullah Ghareeb Wesssam A. Sanad Ashraf Zaytoun Sameh 《The journal of primary prevention》2022,43(5):659-671
Journal of Prevention - Excessive smartphone use leads to several physical and psychological disorders, particularly among young adults. This study aimed to investigate the prevalence and the... 相似文献
24.
25.
Ashraf Imam Cihan Karatas Nesimi Mecit Munci Kalayoglu Turan Kanmaz 《Transplantation proceedings》2021,53(5):1622-1625
BackgroundCardiovascular complication is one of the leading causes of mortality after liver transplantation (LT). Thus, a thorough cardiac evaluation is a must before proceeding to a liver transplant surgery. Percutaneous coronary intervention (PCI) with stent and to a lesser extent coronary artery bypass grafting (CABG) are both valuable treatment options for patients with coronary artery disease.MethodsA retrospective, single-center study that included patients who underwent cardiac intervention and subsequent LT for end-stage liver disease. All patients who had PCI or CABG were included in the study.ResultsTwenty-nine adult patients out of 51 had a cardiac intervention before liver transplantation. Twenty-four patients had a diagnostic PCI, 3 patients had therapeutic PCI with stent, and 2 had failed PCI and proceeded to CABG before liver transplant. The mean age of the patients was 60.5 years. There were 24 men. All patients had cirrhosis. The 2 CABG cases were done during the same admission with a 13- and 18-day interval between the CABG and the transplantation. Both cases were live-related liver transplantation. No mortality was reported.ConclusionIn case of PCI failure, CABG may be a valuable and safe treatment option for cirrhotic patients as a preparation for liver transplantation. Live donor liver transplantation may be a good back-up for those patients in case they develop hepatic decompensation. 相似文献
26.
Ashraf Fansa Alec J. Talsania John G. Kennedy Martin J. O'Malley 《The Journal of foot and ankle surgery》2021,60(3):471-476
Extracorporeal shock wave therapy (ESWT) is a promising treatment for plantar fasciitis (PF), however, treatment results have varied due to inconsistencies among types of shock wave treatment and devices used. This retrospective chart review includes patients who underwent ESWT using the OrthoGold 100? shock wave device (MTS, Konstanz, Germany) for PF between January, 2013 and September, 2018. There were 108 patients (119 heels) identified, with a mean age of 51.7 ± 16.5 (Range 21-83) years. Patients were treated weekly for 3 weeks, with 2000 impulses per session at an energy flux density between 0.10 and 0.17 mJ/mm2. Mean follow-up duration was 11.5 ± 9.7 (Range 3-51) months. Mean pre-ESWT pain visual assessment scale improved from 6.7 ± 1.7 to 2.6 ± 2.7 (p < .001). The Foot and Ankle Outcome Score subscales: pain, function of daily living, function of sports and recreational activities and quality of life domains improved from 53.7 ± 14.9 to 75.7 ± 16.7 (p < .001), from 38 ± 15.2 to 71.8 ± 23 (p < .001), from 55.8 ± 16.4 to 71.4 ± 18 (p < .001), from 42.4 ± 21.5 to 59.4 ± 20.3 (p < .001) and from 44.9 ± 16.4 to 69 ± 23.9 (p < .001), respectively. Eighty-eight (81.5%) patients were satisfied with the procedure at final follow-up. Treatment of PF with unfocused shock waves was well tolerated and led to significant pain reduction, functional improvement, and patient satisfaction. 相似文献
27.
A. Afshan M. Jehangir M. Ashraf A. Wagar E. Chiotellis 《European journal of nuclear medicine and molecular imaging》1994,21(9):991-995
Ethyl cysteinate dimer (ECD) labelled with reduced technetium-99m has recently been proposed as a promising radiopharmaceutical for brain perfusion imaging. In the present study a single-component kit formulation has been developed, thus simplifying the radiolabelling procedure. A method of analysis by electrophoresis has also been developed, permitting identification of radiochemical impurities in the preparation. 99mTc-ECD prepared by the single-component kit was further evaluated in primates and humans. The results demonstrated that the complex is stable in vivo, rapidly extracted and retained in the brain tissue for a sufficient time for single-photon emission tomography studies. Therefore the present single-component kit formulation can be proposed as a reliable instant freeze-dried kit for routine preparation of 99-Tc-ECD required for scintigraphic assessment of regional cerebral blood flow. 相似文献
28.
Jill M. Body Salim I. Butrus Daniel M. Laby M. Farooq Ashraf Andrew I. Rabinowitz D. M. Parenti 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》1995,233(6):374-376
Background: Anterior segment findings in AIDS patients presenting with cytomegalovirus (CMV) retinitis have not been specifically addressed in the American literature. Methods: Our study evaluated 21 AIDS patients with CMV retinitis. Results: Nineteen (90%) of these patients exhibited corneal endothelial deposits concurrent with CMV retinitis. The endothelial deposits were microscopic, opaque, linear flecks arranged in a reticular-like fashion. Of 42 eyes evaluated, 32 (76%) demonstrated active CMV retinitis. Corneal endothelial deposits were noted in 26 (81%) of the 32 eyes with retinitis. These corneal endothelial deposits were absent in the eyes which did not have CMV retinitis. Conclusion: Meticulous examination of the retina of an HIV-positive or AIDS patient who presents with reticularly arranged, linear, flecked corneal endothelial deposits should be performed to ensure that the diagnosis of CMV retinitis can be ruled out. 相似文献
29.
Ashraf Husain Md. Muslim Uddin Kabiraj 《Indian journal of otolaryngology and head and neck surgery》1994,46(2):83-87
The results of analysis of auditory brain- stem evoked responses (ABRS) are reported in 173 patients with delayed speech (DS).
The mean age of the patients is 4.6 years (age ranges from 1.4 years to 10 years). The patients were classified into 5 groups
based on ABR findings:
相似文献
– | Group I (62 patients) had normal hearing threshold and peak- interpeak latencies. The mean amplitude of wave I was however, not significantly low (p < 0.03). |
– | Group II (27 patients) had an increased hearing threshold (40 dB), mild delay in the mean absolute peak latency of wave I (p < 0.03), decreased I– IV interval (p < 0.03), but highly significant reduction of wave I amplitude (p < 0.004). There is also a significant latency delay (p < 0.001) and amplitude reduction (p < 0.05), when this wave is compared with that a Group I (as control). These observations are suggestive of mild degree of peripheral hearing deficit in this group. |
– | Group III (49 patients) had gross ABR abnormalities of various nature and hence may be sub- grouped into (a) SNHL cochlear type (55%) (b) SNHL retrocochlear type (4%) and (c) severed degree of SNHL undecisive group (41%). Ten patients (2.7%) among the sub- group (a) had unilateral hearing loss and another 3 had Down’s syndrome. |
– | Group IV (conductive deafness) had an increased hearing threshold and shifting of ABR waves towards right with normal I– V interval. Only 6 patients were found in this group. It may be that conductive deafness is less important as a cause. |
– | Group V (29 patients) had no responses at repeated ABR studies even at higher intensity of 95 dB, the ABR studies of this group correlates with the clinical evaluation of profound deafness. The delayed speech development in 84 patients (from Groups III, IV and V) may be caused by severe degree of hearing deficit as indicated by marked ABR abnormalities. If the mild peripheral hearing loss in Group II is added to the above groups, ABRs could identify 64.6% of our patients with hearing deficit. Hence, ABR test is most reliable and sensitive diagnostic test in detecting hearing loss, a common cause of delayed speech development in children. |
30.