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991.
Badali H Chander J Bayat M Seyedmousavi S Sidhu S Rani H Attri A Handa U Meis JF de Hoog GS 《Medical mycology》2012,50(2):207-213
Here we report a case of a 55-year-old Indian male presenting with multiple subcutaneous cysts, which developed from painful nodules at the dorsal right wrist joint. Subsequently a painful nodule appeared on the left knee joint. Cytological examination of the knee swelling revealed a suppurative inflammatory lesion consisting of neutrophils, lymphocytes, multinucleated giant cells and few fungal elements, without involvement of the overlying skin. Exophiala spinifera was cultured (CBS 125607) and its identity was confirmed by sequencing of the internal transcribed spacer (ITS rDNA). The cysts were excised surgically, without need of additional antifungal therapy. There was no relapse during one-year follow-up and the patient was cured successfully. In vitro antifungal susceptibility testing showed that posaconazole (0.063 μg/ml) and itraconazole (0.125 μg/ml) had the highest and caspofungin (4 μg/ml) and anidulafungin (2 μg/ml) the lowest activity against this isolate. However, their clinical effectiveness in the treatment of E. spinifera infections remains to be evaluated. In this case report, we have also compiled cases of human E. spinifera mycoses which have been reported so far. 相似文献
992.
Gilard M Eltchaninoff H Iung B Donzeau-Gouge P Chevreul K Fajadet J Leprince P Leguerrier A Lievre M Prat A Teiger E Lefevre T Himbert D Tchetche D Carrié D Albat B Cribier A Rioufol G Sudre A Blanchard D Collet F Dos Santos P Meneveau N Tirouvanziam A Caussin C Guyon P Boschat J Le Breton H Collart F Houel R Delpine S Souteyrand G Favereau X Ohlmann P Doisy V Grollier G Gommeaux A Claudel JP Bourlon F Bertrand B Van Belle E Laskar M;FRANCE Investigators 《The New England journal of medicine》2012,366(18):1705-1715
993.
Patra S Singh V Kumar P Chandra J Dutta A Tripathi M 《Journal of the College of Physicians and Surgeons--Pakistan : JCPSP》2011,21(11):715-717
Sixty-seven children less than two years of age with recurrent wheezing were evaluated clinically and demographically by proper history and clinical examinations. The mean age of the study subjects at enrolment and at onset of wheezing was 10.8 + 5.24 months and 7.1 + 3.857 months, respectively. The male-female ratio was 9:2. The majority of these cases (82%) had onset of wheezing at less than 1 year of age. One-third of the cases were diagnosed as asthma and viral infection associated wheeze. Increasing age in the first 2 years of life was significantly associated with decreasing trend of cases with history suggestive of reflux. The children with wheeze due to causes other than gastroesophageal reflux were more likely to be not exclusively breast fed. The present study did not find any significant difference in the prevalence of various socioeconomic, environmental factors and clinical factors among the various types of the early wheezers. 相似文献
994.
H. Hakan Coskun Alfio Ferlito Jesus E. Medina K. Thomas Robbins Juan P. Rodrigo Primo Strojan Carlos Surez Robert P. Takes Julia A. Woolgar Ashok R. Shaha Remco de Bree Alessandra Rinaldo Carl E. Silver 《Head & neck》2011,33(10):1520-1529
Retropharyngeal lymph node (RPLN) metastasis of primary head and neck cancer often receives less consideration than lymph node metastasis in the neck. With improvements in imaging techniques and reports of surgical pathology, there is an improved understanding of the risk and subsequently the need for treatment of RPLNs. The rates of RPLN metastasis from carcinomas of the nasopharynx, oropharynx, hypopharynx, postcricoid region, maxillary sinus, and cervical esophagus are sufficiently high to warrant routine treatment, either electively or therapeutically, of this region. Through improved diagnostic techniques and heightened awareness of RPLN metastasis, patients at risk of having these metastases can be treated more effectively. © 2010 Wiley Periodicals, Inc. Head Neck, 2010 相似文献
995.
Ferlito A Robbins KT Shah JP Medina JE Silver CE Al-Tamimi S Fagan JJ Paleri V Takes RP Bradford CR Devaney KO Stoeckli SJ Weber RS Bradley PJ Suárez C Leemans CR Coskun HH Pitman KT Shaha AR de Bree R Hartl DM Haigentz M Rodrigo JP Hamoir M Khafif A Langendijk JA Owen RP Sanabria A Strojan P Vander Poorten V Werner JA Bień S Woolgar JA Zbären P Betka J Folz BJ Genden EM Talmi YP Strome M González Botas JH Olofsson J Kowalski LP Holmes JD Hisa Y Rinaldo A 《Head & neck》2011,33(3):445-450
996.
Dinavahi R George A Tretin A Akalin E Ames S Bromberg JS Deboccardo G Dipaola N Lerner SM Mehrotra A Murphy BT Nadasdy T Paz-Artal E Salomon DR Schröppel B Sehgal V Sachidanandam R Heeger PS 《Journal of the American Society of Nephrology : JASN》2011,22(6):1168-1178
Although T and B cell alloimmunity contribute to transplant injury, autoimmunity directed at kidney-expressed, non-HLA antigens may also participate. Because the specificity, prevalence, and importance of antibodies to non-HLA antigens in late allograft injury are poorly characterized, we used a protein microarray to compare antibody repertoires in pre- and post-transplant sera from several cohorts of patients with and without transplant glomerulopathy. Transplantation routinely induced changes in antibody repertoires, but we did not identify any de novo non-HLA antibodies common to patients with transplant glomerulopathy. The screening studies identified three reactivities present before transplantation that persisted after transplant and strongly associated with transplant glomerulopathy. ELISA confirmed that reactivity against peroxisomal-trans-2-enoyl-coA-reductase strongly associated with the development of transplant glomerulopathy in independent validation sets. In addition to providing insight into effects of transplantation on non-HLA antibody repertoires, these results suggest that pretransplant serum antibodies to peroxisomal-trans-2-enoyl-coA-reductase may predict prognosis in kidney transplantation. 相似文献
997.
Nixon IJ Whitcher M Glick J Palmer FL Shaha AR Shah JP Patel SG Ganly I 《Annals of surgical oncology》2011,18(3):800-804
Background
Metastases to the thyroid gland are uncommon, with rates reported between 0.02% and 1.4% of surgically resected thyroid specimens. Our goal was to present our experience with surgical management of metastases to the thyroid gland.Methods
Twenty-one patients with metastatic disease to the thyroid were identified from a database of 1,992 patients with thyroid cancer who had surgery during 1986–2005. Patient, tumor, treatment, and outcome details were recorded by analysis of charts. The median age at time of surgery was 68 (range, 39–83) years; 12 were men and 9 were women.Results
All patients were managed by surgery, including lobectomy in ten patients, total thyroidectomy in six, completion thyroidectomy in two, and subtotal thyroidectomy in one. In two patients, the thyroid lesion was found to be unresectable at the time of surgery. Histopathology revealed renal cell carcinoma in ten, malignant melanoma in three, gastrointestinal adenocarcinoma in three, breast cancer in one, sarcoma in one, and adenocarcinoma from an unknown primary site in three patients. Seventeen patients have died. The cause of death in all 17 was widespread metastatic disease from their respective primary tumors. The median survival from surgery to death or last follow-up was 26.5 (range, 2–114) months.Conclusions
In patients with metastases to the thyroid gland, local control of metastatic disease in the central compartment of the neck can be successfully achieved with minimal morbidity with surgical resection in selected patients. 相似文献998.
Mitra B Pal M Debnath S Paul B Saha TN Maiti A 《International journal of surgery case reports》2011,2(7):194-197
Introduction
Pure squamous cell carcinoma of the breast [SCCB] is rare.Presentation of Case
We report a case of primary squamous cell carcinoma of breast with ipsilateral axillary lymph node metastasis in a 58year old woman.Discussion
It is a breast carcinoma entirely composed of metaplastic squamous cells that may be keratinized, non-keratinized or spindled. The pure squamous cell carcinoma usually present with central cystic cavity, which we found in our case, also supported by immunohistochemical evidence.Conclusion
Although a rare breast cancer subtype, SCCB is of considerable interest due to its pathological heterogeneity and differences in clinical behavior and less reported occurrence of nodal metastasis. 相似文献999.
Dearden CE Khot A Else M Hamblin M Grand E Roy A Hewamana S Matutes E Catovsky D 《Blood》2011,118(22):5799-5802
Intravenous alemtuzumab is an effective and well-tolerated treatment for T-cell prolymphocytic leukemia (T-PLL). Alemtuzumab given intravenously as first-line treatment in 32 patients resulted in an overall response rate of 91% with 81% complete responses. Studies in B-cell chronic lymphocytic leukemia have shown subcutaneous alemtuzumab to be equally as effective as intravenous alemtuzumab. The UKCLL05 pilot study examined the efficacy and toxicity of this more convenient method of administration in 9 previously untreated patients with T-PLL. Only 3 of 9 patients (33%) responded to treatment. Furthermore, 2 of 9 patients (22%) died while on treatment. Recruitment was terminated because of these poor results. After rescue therapy with intravenous alemtuzumab and/or pentostatin, median progression-free survival and overall survival were similar to the intravenous group. Alemtuzumab delivered intravenously, but not subcutaneously, remains the treatment of choice for previously untreated T-PLL. 相似文献
1000.