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11.
Apurva O. Badheka Neeraj Shah Peeyush M. Grover Nileshkumar J. Patel Ankit Chothani Kathan Mehta Vikas Singh Abhishek Deshmukh Ghanshyambhai T. Savani Ankit Rathod Sidakpal S. Panaich Nilay Patel Shilpkumar Arora Vipulkumar Bhalara James O. Coffey Raul D. Mitrani Jonathan L. Halperin Juan F. Viles-Gonzalez 《The American journal of cardiology》2014
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Prospective study of the pattern of lymphatic metastasis in relation to the submandibular gland in patients with carcinoma of the oral cavity
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Sorafenib in advanced clear-cell renal-cell carcinoma 总被引:1,自引:0,他引:1
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Apurva S. More Ronald T. Toth Solomon Z. Okbazghi C. Russell Middaugh Sangeeta B. Joshi Thomas J. Tolbert David B. Volkin David D. Weis 《Journal of pharmaceutical sciences》2018,107(9):2315-2324
We have used hydrogen exchange–mass spectrometry to characterize local backbone flexibility of 4 well-defined IgG1-Fc glycoforms expressed and purified from Pichia pastoris, 2 of which were prepared using subsequent in vitro enzymatic treatments. Progressively decreasing the size of the N-linked N297 oligosaccharide from high mannose (Man8-Man12), to Man5, to GlcNAc, to nonglycosylated N297Q resulted in progressive increases in backbone flexibility. Comparison of these results with recently published physicochemical stability and Fcγ receptor binding data with the same set of glycoproteins provide improved insights into correlations between glycan structure and these pharmaceutical properties. Flexibility significantly increased upon glycan truncation in 2 potential aggregation-prone regions. In addition, a correlation was established between increased local backbone flexibility and increased deamidation at asparagine 315. Interestingly, the opposite trend was observed for oxidation of tryptophan 277 where faster oxidation correlated with decreased local backbone flexibility. Finally, a trend of increasing C'E glycopeptide loop flexibility with decreasing glycan size was observed that correlates with their FcγRIIIa receptor binding properties. These well-defined IgG1-Fc glycoforms serve as a useful model system to identify physicochemical stability and local backbone flexibility data sets potentially discriminating between various IgG glycoforms for potential applicability to future comparability or biosimilarity assessments. 相似文献
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Ashok Apurva Niyogi Devayani Ranganathan Priya Tandon Sandeep Bhaskar Maheema Karimundackal George Jiwnani Sabita Shetmahajan Madhavi Pramesh C. S. 《Surgery today》2020,50(4):323-334
Surgery Today - Esophageal cancer surgery, comprising esophagectomy with radical lymphadenectomy, is a complex procedure associated with considerable morbidity and mortality. The enhanced recovery... 相似文献
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Ha-Soon Choi Paul V. Rucker Zhicheng Wang Yi Fan Pamela Albaugh Greg Chopiuk Francois Gessier Fangxian Sun Francisco Adrian Guoxun Liu Tami Hood Nanxin Li Yong Jia Jianwei Che Susan McCormack Allen Li Jie Li Auzon Steffy AnneMarie Culazzo Celine Tompkins Van Phung Andreas Kreusch Min Lu Bin Hu Apurva Chaudhary Mahavir Prashad Tove Tuntland Bo Liu Jennifer Harris H. Martin Seidel Jon Loren Valentina Molteni 《ACS medicinal chemistry letters》2015,6(5):562-567
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Major Electrocardiographic Abnormalities and 25‐Hydroxy Vitamin D Deficiency: Insights from National Health and Nutrition Examination Survey‐III
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Ricardo O. Escárcega Joseph J. Franco Bhalaghuru Chokkalingam Mani Apurva Vyas Ellen M. Tedaldi Alfred A. Bove 《International journal of cardiology》2014
In 2012, the United Nations estimated that globally, 34 million people were living with human immunodeficiency virus (HIV) infection at the end of 2011. 相似文献