全文获取类型
收费全文 | 6303篇 |
免费 | 411篇 |
国内免费 | 37篇 |
专业分类
耳鼻咽喉 | 63篇 |
儿科学 | 95篇 |
妇产科学 | 153篇 |
基础医学 | 801篇 |
口腔科学 | 63篇 |
临床医学 | 700篇 |
内科学 | 1527篇 |
皮肤病学 | 77篇 |
神经病学 | 557篇 |
特种医学 | 235篇 |
外科学 | 1007篇 |
综合类 | 39篇 |
预防医学 | 332篇 |
眼科学 | 114篇 |
药学 | 396篇 |
中国医学 | 7篇 |
肿瘤学 | 585篇 |
出版年
2024年 | 10篇 |
2023年 | 62篇 |
2022年 | 104篇 |
2021年 | 238篇 |
2020年 | 164篇 |
2019年 | 220篇 |
2018年 | 264篇 |
2017年 | 169篇 |
2016年 | 187篇 |
2015年 | 164篇 |
2014年 | 258篇 |
2013年 | 339篇 |
2012年 | 516篇 |
2011年 | 426篇 |
2010年 | 256篇 |
2009年 | 240篇 |
2008年 | 378篇 |
2007年 | 380篇 |
2006年 | 375篇 |
2005年 | 351篇 |
2004年 | 289篇 |
2003年 | 272篇 |
2002年 | 269篇 |
2001年 | 82篇 |
2000年 | 61篇 |
1999年 | 57篇 |
1998年 | 61篇 |
1997年 | 49篇 |
1996年 | 51篇 |
1995年 | 40篇 |
1994年 | 28篇 |
1993年 | 16篇 |
1992年 | 30篇 |
1991年 | 32篇 |
1990年 | 30篇 |
1989年 | 29篇 |
1988年 | 24篇 |
1987年 | 21篇 |
1986年 | 21篇 |
1985年 | 19篇 |
1984年 | 11篇 |
1983年 | 9篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1976年 | 10篇 |
1973年 | 7篇 |
1972年 | 12篇 |
1970年 | 11篇 |
1969年 | 9篇 |
1967年 | 9篇 |
排序方式: 共有6751条查询结果,搜索用时 15 毫秒
51.
Arnal MA Mosoni L Boirie Y Houlier ML Morin L Verdier E Ritz P Antoine JM Prugnaud J Beaufrère B Mirand PP 《The Journal of nutrition》2000,130(7):1700-1704
This study was undertaken to determine whether a pulse protein feeding pattern was more efficient than a spread pattern to improve protein anabolism in young women as was already shown in elderly women. After a 15-d adaptive period [1.2 g protein/(kg fat-free mass. d)], 16 young women (age 26 +/- 1 y) were given a 14-d diet providing 1.7 g protein/(kg fat-free mass. d), using either a pulse pattern (protein consumed mainly in one meal, n = 8), or a spread pattern (spreading daily protein intake over four meals, n = 8). Nitrogen balance was determined at the end of both the 15-d adaptive and the 14-d experimental periods. Whole-body protein turnover was determined at the end of the 14-d experimental period using [(15)N]glycine as an oral tracer. Nitrogen balance was 17 +/- 5 mg N/(kg fat-free mass. d) during the adaptive period. It was higher during the experimental period, but not significantly different in the women fed the spread or the pulse patterns [59 +/- 12 and 36 +/- 8 mg N/(kg fat-free mass. d) respectively]. No significant effects of the protein feeding pattern were detected on either whole-body protein turnover [5.5 +/- 0.2 vs. 6.1 +/- 0.3 g protein/(kg fat-free mass. d) for spread and pulse pattern, respectively] or whole-body protein synthesis and protein breakdown. Thus, in young women, these protein feeding patterns did not have significantly different effects on protein retention. 相似文献
52.
Véronique Lenoir Marianne Beau Yon de Jonage-Canonico Marie-Hélène Perrin Antoine Martin Robert Scholler Bernard Kerdelhué 《Breast cancer research : BCR》2005,7(4):R470
Introduction
It has been well documented that the pineal hormone, melatonin, which plays a major role in the control of reproduction in mammals, also plays a role in the incidence and growth of breast and mammary cancer. The curative effect of melatonin on the growth of dimethylbenz [a]anthracene-induced (DMBA-induced) mammary adenocarcinoma (ADK) has been previously well documented in the female Sprague-Dawley rat. However, the preventive effect of melatonin in limiting the frequency of cancer initiation has not been well documented. 相似文献53.
Chen Guang Yang Joseph Ciccolini Aurore Blesius Laetitia Dahan Danielle Bagarry-Liegey Caroline Brunet Arthur Varoquaux Nicolas Frances Hafedh Marouani Antoine Giovanni Rose-Marie Ferri-Dessens Mohamed Chefrour Roger Favre Florence Duffaud Jean-Fran?ois Seitz Michel Zanaret Bruno Lacarelle C��dric Mercier 《Cancer chemotherapy and pharmacology》2011,67(1):49-56
Background
Fluoropyrimidine drugs are widely used in head and neck cancer (HNC). DPD deficiency is a pharmacogenetics syndrome associated with severe/lethal toxicities upon 5-FU or capecitabine intake. We have developed a simple, rapid, and inexpensive functional testing for DPD activity, as a means to identify deficient patients and to anticipate subsequent 5-FU-related toxicities. We present here the impact of fluoropyrimidine dose tailoring based on DPD functional screening in a prospective, open, non-controlled study, both in term of reduction in severe toxicities and of treatment efficacy.Methods
About 65 patients with HNC (59?±?9?years, 52M/13F, Prospective Group) were entered into the study. Screening for DPD deficiency was performed prior to the beginning of the chemotherapy or radiochemotherapy. DPD status was evaluated by monitoring U/UH2 ratio levels in plasma as a surrogate marker for enzymatic functionality. 5-FU doses were reduced according to the extent of the detected DPD impairment, and adjusted on the basis of age, general condition, and other clinical/paraclinical covariates, if required. Treatment-related toxicities and subsequent impact on treatment delay were carefully monitored next for comparison with a retrospective, Reference subset of 74 other patients with HNC (mean age: 59?±?10, 58M/16F, Reference Group), previously treated in the same institute with similar schedule but using standard 5-FU dosage.Results
Thirty-one out of 65 patients (48%) were identified as mildly (28%) to markedly (20%) DPD deficient. Subsequently, dose reductions ranging from 10 to 100% with 5-FU were applied in those patients. In this group, six patients (9%) experienced severe toxicities, none of them being life threatening, and no toxic death was encountered. In comparison, 16 out of 74 patients (22%) of the Reference Group displayed severe side effects after standard 5-FU administration, 13% being life-threatening toxicities (e.g., G4 neutropenia?+?sepsis). Moreover, one toxic death was observed in this Reference Group. No postponement or cancelation of forthcoming chemoradiotherapy courses occurred in the Prospective Group, whereas treatment had to be disrupted in six patients (8%) from the Reference Group. No difference in first-line therapy efficacy was evidenced between the two subsets (78 vs. 79% response, P?=?0.790).Conclusions
Although non-randomized, this study strongly suggests that prospective determination of DPD status has an immediate clinical benefit by reducing the drug-induced toxicities incidence in patients treated with 5-FU, allowing an optimal administration of several courses in a row, while maintaining efficacy. Our preliminary results thus advocate for systematic DPD screening in patients eligible for treatment with fluoropyrimidine drugs in HNC. 相似文献54.
55.
56.
57.
Bozec Alexandre Schultz Philippe Gal Jocelyn Chamorey Emmanuel Chateau Yann Dassonville Olivier Poissonnet Gilles Peyrade Frédéric Saada Esma Guigay Joël Benezery Karen Leysalle Axel Santini Laure Giovanni Antoine Messaoudi Lila Fakhry Nicolas 《European archives of oto-rhino-laryngology》2019,276(9):2531-2539
European Archives of Oto-Rhino-Laryngology - Providing cancer patients with adequate information is essential to their confidence and satisfaction regarding medical care. The aims of this study... 相似文献
58.
59.
Axel Olsen T. Antoine Frommolt Theo Pütz Rudolf Koch Hans Heidler Kurt Walther Schultze H. A. Schmitz Elisabeth Koch Möhlmann Diethelm W. Janisch-Raschkowitsch Hansen Ostertag H. Dietel 《International journal of legal medicine》1943,37(3-4):197-206
Ohne Zusammenfassung 相似文献
60.