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61.
Merviel P Mergui JL Sananes S Antoine JM Salat-Baroux J Uzan S 《Presse medicale (Paris, France : 1983)》2000,29(23):1302-1310
UTERINE DISORDERS: Because they can prevent implantation, anomalies within the uterine cavity play an important role in fertility. The uterine disorders most often observed during hysteroscopy and implicated in infertility are adhesions, septa, polyps, submucous myomas, adenomyosis, endometritis, anomalies of the cervical canal, and lesions of the uterotubal junction. EXPLORATIONS: Hysterosalpingography can be used to evaluate tubal permeability but provides inadequate information about the uterine cavity (numerous false-positives and false-negatives). Pelvic ultrasound is especially helpful for diagnosing interstitial anomalies in the uterus. HYSTEROSCOPY: Diagnostic hysteroscopy also has a place in infertility investigations, for it allows direct visualization of the uterine cavity, the endometrial mucus (endometritis, adenomyosis), and the cervical canal. The examination is practiced on a out-patient basis, without anesthesia, using appropriate small-caliber instruments and irrigation with physiological saline. Surgical hysteroscopy is used to treat these anomalies. Patients receive general anesthesia. A high-frequency, low-voltage electric current is used, and glycine for irrigation. This procedure allows resection of submucous myomas and polyps and of septa and adhesions. Some groups use laser beams and irrigation by physiological saline for these treatments. Coagulation of a superficial focal spot of adenomyosis is not useful in infertility therapy. RESULTS: As assessed by the percentage of patients with each indication who subsequently became pregnant, the results of surgical hysteroscopy have been satisfactory: 62 per cent (%) of cases after myomectomy, 66% after section of uterine septa, and 61% after treatment of complicated adhesions. A new exploration of the uterine cavity will be necessary sometime after the surgery to verify the absence of any iatrogenic disorders (adhesions, myomatous fragments). 相似文献
62.
Arnal MA Mosoni L Boirie Y Houlier ML Morin L Verdier E Ritz P Antoine JM Prugnaud J Beaufrère B Mirand PP 《The Journal of nutrition》2000,130(7):1700-1704
This study was undertaken to determine whether a pulse protein feeding pattern was more efficient than a spread pattern to improve protein anabolism in young women as was already shown in elderly women. After a 15-d adaptive period [1.2 g protein/(kg fat-free mass. d)], 16 young women (age 26 +/- 1 y) were given a 14-d diet providing 1.7 g protein/(kg fat-free mass. d), using either a pulse pattern (protein consumed mainly in one meal, n = 8), or a spread pattern (spreading daily protein intake over four meals, n = 8). Nitrogen balance was determined at the end of both the 15-d adaptive and the 14-d experimental periods. Whole-body protein turnover was determined at the end of the 14-d experimental period using [(15)N]glycine as an oral tracer. Nitrogen balance was 17 +/- 5 mg N/(kg fat-free mass. d) during the adaptive period. It was higher during the experimental period, but not significantly different in the women fed the spread or the pulse patterns [59 +/- 12 and 36 +/- 8 mg N/(kg fat-free mass. d) respectively]. No significant effects of the protein feeding pattern were detected on either whole-body protein turnover [5.5 +/- 0.2 vs. 6.1 +/- 0.3 g protein/(kg fat-free mass. d) for spread and pulse pattern, respectively] or whole-body protein synthesis and protein breakdown. Thus, in young women, these protein feeding patterns did not have significantly different effects on protein retention. 相似文献
63.
Véronique Lenoir Marianne Beau Yon de Jonage-Canonico Marie-Hélène Perrin Antoine Martin Robert Scholler Bernard Kerdelhué 《Breast cancer research : BCR》2005,7(4):R470
Introduction
It has been well documented that the pineal hormone, melatonin, which plays a major role in the control of reproduction in mammals, also plays a role in the incidence and growth of breast and mammary cancer. The curative effect of melatonin on the growth of dimethylbenz [a]anthracene-induced (DMBA-induced) mammary adenocarcinoma (ADK) has been previously well documented in the female Sprague-Dawley rat. However, the preventive effect of melatonin in limiting the frequency of cancer initiation has not been well documented. 相似文献64.
Chen Guang Yang Joseph Ciccolini Aurore Blesius Laetitia Dahan Danielle Bagarry-Liegey Caroline Brunet Arthur Varoquaux Nicolas Frances Hafedh Marouani Antoine Giovanni Rose-Marie Ferri-Dessens Mohamed Chefrour Roger Favre Florence Duffaud Jean-Fran?ois Seitz Michel Zanaret Bruno Lacarelle C��dric Mercier 《Cancer chemotherapy and pharmacology》2011,67(1):49-56
Background
Fluoropyrimidine drugs are widely used in head and neck cancer (HNC). DPD deficiency is a pharmacogenetics syndrome associated with severe/lethal toxicities upon 5-FU or capecitabine intake. We have developed a simple, rapid, and inexpensive functional testing for DPD activity, as a means to identify deficient patients and to anticipate subsequent 5-FU-related toxicities. We present here the impact of fluoropyrimidine dose tailoring based on DPD functional screening in a prospective, open, non-controlled study, both in term of reduction in severe toxicities and of treatment efficacy.Methods
About 65 patients with HNC (59?±?9?years, 52M/13F, Prospective Group) were entered into the study. Screening for DPD deficiency was performed prior to the beginning of the chemotherapy or radiochemotherapy. DPD status was evaluated by monitoring U/UH2 ratio levels in plasma as a surrogate marker for enzymatic functionality. 5-FU doses were reduced according to the extent of the detected DPD impairment, and adjusted on the basis of age, general condition, and other clinical/paraclinical covariates, if required. Treatment-related toxicities and subsequent impact on treatment delay were carefully monitored next for comparison with a retrospective, Reference subset of 74 other patients with HNC (mean age: 59?±?10, 58M/16F, Reference Group), previously treated in the same institute with similar schedule but using standard 5-FU dosage.Results
Thirty-one out of 65 patients (48%) were identified as mildly (28%) to markedly (20%) DPD deficient. Subsequently, dose reductions ranging from 10 to 100% with 5-FU were applied in those patients. In this group, six patients (9%) experienced severe toxicities, none of them being life threatening, and no toxic death was encountered. In comparison, 16 out of 74 patients (22%) of the Reference Group displayed severe side effects after standard 5-FU administration, 13% being life-threatening toxicities (e.g., G4 neutropenia?+?sepsis). Moreover, one toxic death was observed in this Reference Group. No postponement or cancelation of forthcoming chemoradiotherapy courses occurred in the Prospective Group, whereas treatment had to be disrupted in six patients (8%) from the Reference Group. No difference in first-line therapy efficacy was evidenced between the two subsets (78 vs. 79% response, P?=?0.790).Conclusions
Although non-randomized, this study strongly suggests that prospective determination of DPD status has an immediate clinical benefit by reducing the drug-induced toxicities incidence in patients treated with 5-FU, allowing an optimal administration of several courses in a row, while maintaining efficacy. Our preliminary results thus advocate for systematic DPD screening in patients eligible for treatment with fluoropyrimidine drugs in HNC. 相似文献65.
66.
Long‐term recurrence of soft tissue sarcomas: Prognostic factors and implications for prolonged follow‐up 下载免费PDF全文
Maud Toulmonde MD Axel Le Cesne MD Jean Mendiboure MSc Jean‐Yves Blay MD PhD Sophie Piperno‐Neumann MD Christine Chevreau MD Corinne Delcambre MD Nicolas Penel MD PhD Philippe Terrier MD Dominique Ranchère‐Vince MD Marick Lae MD Sophie Le Guellec MD Jean‐Jacques Michels MD Yves‐Marie Robin MD Carine Bellera PhD Antoine Italiano MD PhD 《Cancer》2014,120(19):3003-3006
67.
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69.
Bozec Alexandre Schultz Philippe Gal Jocelyn Chamorey Emmanuel Chateau Yann Dassonville Olivier Poissonnet Gilles Peyrade Frédéric Saada Esma Guigay Joël Benezery Karen Leysalle Axel Santini Laure Giovanni Antoine Messaoudi Lila Fakhry Nicolas 《European archives of oto-rhino-laryngology》2019,276(9):2531-2539
European Archives of Oto-Rhino-Laryngology - Providing cancer patients with adequate information is essential to their confidence and satisfaction regarding medical care. The aims of this study... 相似文献
70.