全文获取类型
收费全文 | 922篇 |
免费 | 26篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 19篇 |
妇产科学 | 53篇 |
基础医学 | 156篇 |
口腔科学 | 5篇 |
临床医学 | 90篇 |
内科学 | 184篇 |
皮肤病学 | 9篇 |
神经病学 | 87篇 |
特种医学 | 39篇 |
外科学 | 88篇 |
预防医学 | 59篇 |
眼科学 | 7篇 |
药学 | 41篇 |
中国医学 | 1篇 |
肿瘤学 | 105篇 |
出版年
2024年 | 2篇 |
2023年 | 17篇 |
2022年 | 25篇 |
2021年 | 57篇 |
2020年 | 25篇 |
2019年 | 34篇 |
2018年 | 34篇 |
2017年 | 19篇 |
2016年 | 20篇 |
2015年 | 23篇 |
2014年 | 35篇 |
2013年 | 52篇 |
2012年 | 85篇 |
2011年 | 82篇 |
2010年 | 34篇 |
2009年 | 42篇 |
2008年 | 60篇 |
2007年 | 67篇 |
2006年 | 53篇 |
2005年 | 46篇 |
2004年 | 38篇 |
2003年 | 39篇 |
2002年 | 37篇 |
2001年 | 3篇 |
2000年 | 1篇 |
1999年 | 8篇 |
1998年 | 2篇 |
1997年 | 2篇 |
1996年 | 1篇 |
1994年 | 1篇 |
1992年 | 1篇 |
1990年 | 1篇 |
1989年 | 2篇 |
排序方式: 共有948条查询结果,搜索用时 15 毫秒
81.
82.
Kobelt G Woronoff AS Richard B Peeters P Sany J 《Joint, bone, spine : revue du rhumatisme》2008,75(4):408-415
ObjectiveTo investigate resource consumption and quality of life (utility) in a sample of patients covering the full spectrum of the disease, modalities of patient management and geographic areas.MethodsInformation on demographics, disease parameters, work capacity and resource consumption (in the past 1, 3 or 12 months depending on the resource) was collected in an anonymous mail survey from all members of a national patient association (ANDAR). Results are presented for the sample and by level of functional capacity, in €2005.Results1487 patients were included in the analysis (response rate 49%). Mean age was 62.7 years and 83.5% of respondents were female. Mean disease duration was 18 years; mean HAQ was 1.42; fatigue and pain ranked 5.6 and 4.8 on a scale between 0 and 10, respectively. Of patients below 60 years, 34% had taken early retirement due to RA, and only 15% of patients with a HAQ of 2 or higher were working. Productivity losses were estimated at €5076, of which indemnity payments covered €1944. Direct health care costs were €11,757 in the societal perspective and €9216 in the perspective of the national health insurance. Direct non-medical costs (including informal care) were €4857 and €136 respectively. Costs to society increased from €9400 in mild disease to €40,700 in severe disease, and to public payers from €6000 to €19,000. Utility decreased simultaneously from 0.80 to 0.06.ConclusionThe study confirms overall findings in other studies in other countries, and provides the first estimate of all costs by disease severity in France. 相似文献
83.
Ghobrial J Ghobrial IM Mitsiades C Leleu X Hatjiharissi E Moreau AS Roccaro A Schlossman R Hideshima T Anderson KC Richardson P 《Oncology (Williston Park, N.Y.)》2007,21(7):785-92; discussion 798-800
Our better understanding of the complex interaction of multiple myeloma (MM) cells with their bone marrow microenvironment and the signaling pathways that are dysregulated in this process has resulted in a dramatic increase in the therapeutic agents available for this disease. A number of these new agents have demonstrated significant activity in patients with MM. Over the past 5 years, three drugs have received approval from the US Food and Drug Administration for therapy in MM--bortezomib, thalidomide, and lenalidomide. To date, the choice of therapy for MM is not individualized according to the biologic characteristics of the disease, but future studies should enable us to identify patients who may benefit most from certain therapeutic interventions, and thus develop individualized therapy for MM. In this review, we will present some of the treatment algorithms currently developed for patients with MM and focus on established advances in therapy, specifically with thalidomide, bortezomib, and lenalidomide. We will also discuss some of the emerging novel therapeutic agents showing promise in phase I/II clinical trials in MM. 相似文献
84.
The antiestrogen tamoxifen activates BK channels and stimulates proliferation of MCF-7 breast cancer cells 总被引:5,自引:0,他引:5
Coiret G Borowiec AS Mariot P Ouadid-Ahidouch H Matifat F 《Molecular pharmacology》2007,71(3):843-851
In the present study, we investigated the effect of the antiestrogen compound tamoxifen on BK channels by the use of the patch-clamp technique. The perfusion of 10 nM tamoxifen significantly increased the magnitude of a voltage-dependent K+ current by 22.6 +/- 10.6% (n = 23). The effect of tamoxifen was always obtained in the first minute, peaked at 5.9 +/- 2.2 min (n = 23), and was abolished by the perfusion of tetraethylammonium (0.5 mM), charybdotoxin (50 nM), or iberiotoxin (100 nM). The stimulatory effect of 10 nM tamoxifen was the same at low (50 nM) and high (700 nM) internal calcium concentration and was not additive to that of 17-beta-estradiol (E2) or its membrane-impermeant form, beta-estradiol 6-(O-carboxymethyl)oxime:bovine serum albumin. Furthermore, the effect of tamoxifen was still recorded in the presence of the selective estrogen receptor antagonist faslodex (ICI-182,780; 1 microM). At the single-channel level, tamoxifen significantly increased the open probability of the BK channel by 46.2 +/- 10.1% (n = 4) without changing its unitary conductance. Moreover, we show here that the stimulation of BK channel activity by tamoxifen is involved in MCF-7 cell proliferation. Taken together, these results permitted us to identify the BK channel as the molecular target of tamoxifen that probably acts at the same extracellular molecular level as E2. The site of action of tamoxifen is probably the channel itself or the auxiliary beta subunits. 相似文献
85.
Hirabidian Mickaël Thierry Saelens Deleplancque Anne-Sophie Bergues Benoît Loridant Séverine Cornu Marjorie Sendid Boualem Leroy Jordan 《European journal of clinical microbiology & infectious diseases》2023,42(6):781-786
European Journal of Clinical Microbiology & Infectious Diseases - Toxocariasis is a cosmopolitan helminthiasis linked to contamination with Toxocara cati or Toxocara canis. Only six isolated... 相似文献
86.
87.
88.
Geoffrey Cheminet Antoine Brunetti Djamal Khimoud Brigitte Ranque Adrien Michon Edouard Flamarion Jacques Pouchot Anne-Sophie Jannot Jean-Benoît Arlet 《British journal of haematology》2023,201(6):1229-1238
Data on acute chest syndrome (ACS) in adult sickle cell disease patients are scarce. In this study, we describe 105 consecutive ACS episodes in 81 adult patients during a 32-month period and compare the characteristics as a function of the time to onset after hospital admission for a vaso-occlusive crisis (VOC), that is early-onset episodes (time to onset ≤24 h, 42%) versus secondary episodes (>24 h, 58%; median [interquartile range] time to onset: 2 [2–3] days). The median age was 27 [22–34] years, 89% of the patients had an S/S or S/β0-thalassaemia genotype; 81% of the patients had a history of ACS (median: 3 [2–5] per patient), only 61% were taking a disease-modifying treatment at the time of the ACS. Fever and chest pain were noted in respectively 54% and 73% of the episodes. Crackles (64%) and bronchial breathing (32%) were the main abnormal auscultatory findings. A positive microbiological test was found for 20% of episodes. Fifty percent of the episodes required a blood transfusion; ICU transfer and mortality rates were respectively 29% and 1%. Secondary and early-onset forms of ACS did not differ significantly. Disease-modifying treatments should be revaluated after each ACS episode because the recurrence rate is high. 相似文献
89.
90.
Anne-Sophie Schneck Antonio Iannelli Stéphanie Patouraux Déborah Rousseau Stéphanie Bonnafous Beatrice Bailly-Maitre Ophélia Le Thuc Carole Rovere Patricia Panaia-Ferrari Rodolphe Anty Albert Tran Philippe Gual Jean Gugenheim 《Surgical endoscopy》2014,28(2):592-602