全文获取类型
收费全文 | 298688篇 |
免费 | 38913篇 |
国内免费 | 3246篇 |
专业分类
耳鼻咽喉 | 6585篇 |
儿科学 | 10307篇 |
妇产科学 | 5946篇 |
基础医学 | 25110篇 |
口腔科学 | 6016篇 |
临床医学 | 40094篇 |
内科学 | 79939篇 |
皮肤病学 | 10763篇 |
神经病学 | 29462篇 |
特种医学 | 9638篇 |
外国民族医学 | 1篇 |
外科学 | 53457篇 |
综合类 | 906篇 |
现状与发展 | 73篇 |
一般理论 | 89篇 |
预防医学 | 21821篇 |
眼科学 | 5764篇 |
药学 | 11789篇 |
中国医学 | 549篇 |
肿瘤学 | 22538篇 |
出版年
2024年 | 850篇 |
2023年 | 6137篇 |
2022年 | 4537篇 |
2021年 | 8617篇 |
2020年 | 9174篇 |
2019年 | 6641篇 |
2018年 | 12194篇 |
2017年 | 11010篇 |
2016年 | 12631篇 |
2015年 | 13103篇 |
2014年 | 21650篇 |
2013年 | 23710篇 |
2012年 | 18072篇 |
2011年 | 18410篇 |
2010年 | 17113篇 |
2009年 | 19792篇 |
2008年 | 15859篇 |
2007年 | 14135篇 |
2006年 | 15747篇 |
2005年 | 12359篇 |
2004年 | 10798篇 |
2003年 | 8923篇 |
2002年 | 8284篇 |
2001年 | 4469篇 |
2000年 | 3491篇 |
1999年 | 3966篇 |
1998年 | 4647篇 |
1997年 | 4291篇 |
1996年 | 4004篇 |
1995年 | 3779篇 |
1994年 | 2487篇 |
1993年 | 2011篇 |
1992年 | 1723篇 |
1991年 | 1654篇 |
1990年 | 1284篇 |
1989年 | 1409篇 |
1988年 | 1228篇 |
1987年 | 1035篇 |
1986年 | 1080篇 |
1985年 | 866篇 |
1984年 | 739篇 |
1983年 | 706篇 |
1982年 | 729篇 |
1981年 | 563篇 |
1980年 | 539篇 |
1979年 | 406篇 |
1978年 | 432篇 |
1977年 | 499篇 |
1975年 | 342篇 |
1972年 | 342篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
1.
2.
3.
4.
5.
Very preterm children are at increased risk of reduced processing speed at 5 years of age,predicted by typical complications of prematurity and prenatal smoking 下载免费PDF全文
6.
7.
Vassiliki Costarelli Maria Michou Demosthenes B. Panagiotakos Christos Lionis 《International journal of food sciences and nutrition》2021,72(1):112-122
AbstractThe study examines Parental Feeding Practices (PFP) in relation to adherence to the Mediterranean Diet (MD) and children’s weight status. It’s a cross-sectional study of 402 parents (68.4% mothers), with children aged 2–12 years. Parents completed the Comprehensive Parental Feeding Questionnaire and the Mediterranean Diet Quality Index for children and adolescents (KIDMED), evaluating children’s adherence to the MD. Logistic regression showed that in children aged 2–<6 years, “emotion regulation/food as reward” and “pressure” decrease MD adherence (OR?=?0.186, p?<?0.0001 and OR?=?0.496, p?=?0.004), and “monitoring” decrease excess body weight (OR?=?0.284, p?=?0.009). In older children (6–12 years), “healthy eating guidance” and “monitoring” increase MD adherence (OR?=?3.262, p?=?0.001 and OR?=?3.147, p?<?0.0001), “child control” decreases MD adherence (OR?=?0.587, p?=?0.049), “pressure” decrease excess body weight (OR?=?0.495, p?<?0.0001) and “restriction” increase excess body weight (OR?=?1.784, p?=?0.015). “Healthy eating guidance” and “monitoring” seem to be the best PFP employed, in terms of children’s MD adherence and weight status. 相似文献
8.
Jae Eun Choi Tyler Werbel Zhenping Wang Chia Chi Wu Tony L. Yaksh Anna Di Nardo 《Journal of dermatological science》2019,93(1):58-64
Background
Rosacea is a chronic inflammatory skin condition whose etiology has been linked to mast cells and the antimicrobial peptide cathelicidin LL-37. Individuals with refractory disease have demonstrated clinical benefit with periodic injections of onabotulinum toxin, but the mechanism of action is unknown.Objectives
To investigate the molecular mechanism by which botulinum toxin improves rosacea lesions.Methods
Primary human and murine mast cells were pretreated with onabotulinum toxin A or B or control. Mast cell degranulation was evaluated by β-hexosaminidase activity. Expression of botulinum toxin receptor Sv2 was measured by qPCR. The presence of SNAP-25 and VAMP2 was established by immunofluorescence. In vivo rosacea model was established by intradermally injecting LL-37 with or without onabotulinum toxin A pretreatment. Mast cell degranulation was assessed in vivo by histologic counts. Rosacea biomarkers were analyzed by qPCR of mouse skin sections.Results
Onabotulinum toxin A and B inhibited compound 48/80-induced degranulation of both human and murine mast cells. Expression of Sv2 was established in mouse mast cells. Onabotulinum toxin A and B increased cleaved SNAP-25 and decreased VAMP2 staining in mast cells respectively. In mice, injection of onabotulinum toxin A significantly reduced LL-37-induced skin erythema, mast cell degranulation, and mRNA expression of rosacea biomarkers.Conclusions
These findings suggest that onabotulinum toxin reduces rosacea-associated skin inflammation by directly inhibiting mast cell degranulation. Periodic applications of onabotulinum toxin may be an effective therapy for refractory rosacea and deserves further study. 相似文献9.
Srdan Verstovsek MD PhD Jean-Jacques Kiladjian MD PhD Alessandro M. Vannucchi MD Ruben A. Mesa MD FACP Peg Squier MD PhD J. E. Hamer-Maansson MSPH Claire Harrison MD 《Cancer》2023,129(11):1681-1690
Background
In a pooled analysis of the phase 3 Controlled Myelofibrosis Study With Oral JAK Inhibitor Treatment I (COMFORT-I) and COMFORT-II clinical trials, adult patients with intermediate-2 or high-risk myelofibrosis who received oral ruxolitinib at randomization or after crossover from placebo or best available therapy (BAT) had improved overall survival (OS).Methods
This post hoc analysis of pooled COMFORT data examined relevant disease outcomes based on the disease duration (≤12 or >12 months from diagnosis) before ruxolitinib initiation.Results
The analysis included 525 patients (ruxolitinib: ≤12 months, n = 84; >12 months, n = 216; placebo/BAT: ≤12 months, n = 66; >12 months, n = 159); the median age was 65.0–70.0 years. Fewer thrombocytopenia and anemia events were observed among patients who initiated ruxolitinib treatment earlier. At Weeks 24 and 48, the spleen volume response (SVR) was higher for patients who initiated ruxolitinib earlier (47.6% vs. 32.9% at Week 24, p = .0610; 44.0% vs. 26.9% at Week 48, p = .0149). In a multivariable analysis of factors associated with spleen volume reduction, a logistic regression model that controlled for confounding factors found that a significantly greater binary reduction was observed among patients with shorter versus longer disease duration (p = .022). At Week 240, OS was significantly improved among patients who initiated ruxolitinib earlier (63% [95% CI, 51%‒73%] vs. 57% [95% CI, 49%‒64%]; hazard ratio, 1.53; 95% CI, 1.01‒2.31; p = .0430). Regardless of disease duration, a longer OS was observed for patients who received ruxolitinib versus those who received placebo/BAT.Conclusions
These findings suggest that earlier ruxolitinib initiation for adult patients with intermediate-2 and high-risk myelofibrosis may improve clinical outcomes, including fewer cytopenia events, durable SVR, and prolonged OS.Plain Language Summary
- Patients with myelofibrosis, a bone marrow cancer, often do not live as long as the general population. These patients may also have an enlarged spleen and difficult symptoms such as fatigue.
- Two large clinical trials showed that patients treated with the drug ruxolitinib lived longer and had improved symptoms compared to those treated with placebo or other standard treatments.
- Here it was examined whether starting treatment with ruxolitinib earlier (i.e., within a year of diagnosis) provided benefits versus delaying treatment.
- Patients who received ruxolitinib within a year of diagnosis lived longer and experienced fewer disease symptoms than those whose treatment was delayed.