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Robert J. Reitz Angelina Dreimiller Alina Khil Edward Horwitz Christopher R. McHenry 《Surgery》2021,169(3):513-518
BackgroundThe aims of this study were to determine the rate of ectopic and supernumerary parathyroid glands and the outcome of surgical therapy in patients with refractory renal hyperparathyroidism.Materials and MethodsA retrospective review of all patients who underwent parathyroidectomy for refractory renal hyperparathyroidism was completed. Operative and pathology reports were reviewed, and the number and location of resected parathyroid glands, patient outcomes, and follow-up were determined.ResultsDuring the period 1993–2019, a total of 68 patients underwent subtotal or total parathyroidectomy for renal hyperparathyroidism. Of those, 59 patients (87%) were on dialysis for an average of 6.7 years. We determined that 18 patients (26%) had 24 ectopic parathyroid glands, including 9 (13%) patients with 11 supernumerary glands. A total of 2 patients had a supernumerary gland in a normal anatomic location. Of the 24 ectopic glands, 14 (58%) were in the thymus. After parathyroidectomy, 4 patients (5.9%) had persistent hyperparathyroidism, 6 patients (8.8%) developed recurrent hyperparathyroidism, and 2 patients (3%) had permanent hypoparathyroidism.ConclusionEctopic and supernumerary parathyroid glands occurred in 26% and 16% of patients with renal hyperparathyroidism, respectively, and the thymus was the most common location. Thorough neck exploration and transcervical thymectomy are important to help reduce persistent and recurrent hyperparathyroidism after parathyroidectomy for renal hyperparathyroidism. 相似文献
23.
Grey matter brain injuries are common in Ugandan children with cerebral palsy suggesting a perinatal aetiology in full‐term infants
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24.
Melissa A. Valerio Edward L. Peterson Angelina R. Wittich Christine L. M. Joseph 《The Journal of asthma》2016,53(10):1041-1047
Objective: This exploratory study assessed health literacy among urban African-American high school students to improve understanding of the association between adolescent health literacy and asthma. Methods: We conducted a secondary data analysis of the control group (n = 181) of the Puff City randomized controlled trial (2006–2010), a web-based intervention to promote asthma management among students, grades 9 through 12. A validated self-report 3-item health literacy screening instrument was completed at final online follow-up survey. Logistic regression was used to explore the association between health literacy, demographic characteristics, quality of life, asthma management, and health care utilization. Results: Multivariate analysis revealed that an overall inadequate health literacy score was associated with students who were more likely to be younger (OR 0.61; 95% CI 0.44–0.84), not on Medicaid (OR 0.36; 95% CI 0.17–0.76), have at least one hospitalization (OR 1.29; 95% CI 1.07–1.56); and a lower overall quality of life (OR 0.75; 95% CI 0.59–0.95). Those lacking confidence in filling out medical forms, needing help reading hospital materials, and having difficulty understanding written information were more likely to not have a rescue inhaler (OR 0.49; 95% CI 0.25–0.94), have one or more emergency visits (OR 1.21 95% CI 1.02–1.43), and one or more hospitalizations (OR 1.19; 95% CI 1.01–1.41), respectively. Conclusions: The findings indicate a significant association between inadequate health literary and suboptimal asthma management. It is important to advance understanding of adolescent health literacy, especially those at-risk, as they assume asthma self-management tasks and move toward independent adult self-care. 相似文献
25.
Francisco J Gómez-Pérez Carlos A Aguilar-Salinas Cuauhtémoc Vázquez-Chávez Guillermo Fangh?nel-Salmón José Gallegos-Martínez Rita A Gómez-Diaz Saul Salinas-Orozco Ismael J Chavira-López Leticia Sánchez-Reyes Evelyn M Torres-Acosta Ricardo Tamez Angelina López Luz E Guillén Gabriela Cesarman 《Metabolism: clinical and experimental》2002,51(1):44-51
The effects of troglitazone 400 or 600 mg/d on the glycemic control, very-low-density lipoprotein (VLDL), and high-density lipoprotein (HDL) subclass concentrations and plasminogen-activator inhibitor 1 (PAI-1) levels were assessed in patients with type 2 diabetes that had not been controlled with dietary treatment. This was a multicenter, open-label, parallel-groups study. It included a run-in 4-week diet period and a 24-week randomized treatment. Fifty one patients received 400 mg/d and 55 patients 600 mg. The mean HbA(1c) concentration at the end of the study was similar for both doses. Troglitazone, regardless of dose, significantly improved insulin sensitivity assessed by the homeostasis model (HOMA). PAI-1 levels were significantly decreased in both groups by 13%. Higher HDL cholesterol concentrations and lower triglycerides levels were observed at the end of treatment. Triglyceride contents were reduced only in the lighter VLDL1. The change in HDL cholesterol concentration resulted from a combination of increased HDL3 cholesterol and lower HDL2 cholesterol levels. No differences were found in the effects of both treatment groups on the evaluated parameters. Our data provide new information about the actions of the drug on the lipid profile. Troglitazone reduces triglyceride levels by lowering the triglycerides content of the VLDL1 particles and increases HDL cholesterol concentrations by increasing HDL3 cholesterol levels. 相似文献
26.
Barsky Maria Meserve Joseph Le Helen Collins Angelina Singh Siddharth Boland Brigid Sandborn William J. Dulai Parambir S. 《Digestive diseases and sciences》2021,66(8):2564-2569
Digestive Diseases and Sciences - Evidence is now available in support of using fecal biomarkers to monitor disease activity in inflammatory bowel disease (IBD). Patient adherence is often cited as... 相似文献
27.
Antonio Siniscalchi Antonello Bonci Bonci Nicola Biagio Mercuri Domenico Pirritano Aida Squillace Giovambattista De Sarro Luca Gallelli 《Current Neuropharmacology》2015,13(6):815-818
Topiramate (TPM) is an antiepileptic drug able to play a role in both neurological and
psychiatric disorders. TPM facilitates gamma-aminobutyric acid (GABA) transmission and inhibits
glutamatergic transmission (i.e. AMPA/kainate receptors).Several studies reported that the modulation of GABAergic and glutamatergic synaptic transmission may reduce cocaine
reinforcement. Therefore, TPM could be used in the management of cocaine dependence. 相似文献
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Concetta Cafiero Giuseppe Marangi Daniela Orteschi Marwan Ali Alessia Asaro Emanuela Ponzi Alice Moncada Stefania Ricciardi Marina Murdolo Giorgia Mancano Ilaria Contaldo Vincenzo Leuzzi Domenica Battaglia Eugenio Mercuri Anne M Slavotinek Marcella Zollino 《European journal of human genetics : EJHG》2015,23(11):1499-1504
MED13L haploinsufficiency has recently been described as responsible for syndromic intellectual disability. We planned a search for causative gene variants in seven subjects with intellectual disability and overlapping dysmorphic facial features such as bulbous nasal tip, short mouth and straight eyebrows. We found two de novo frameshift variants in MED13L, consisting in single-nucleotide deletion (c.3765delC) and duplication (c.607dupT). A de novo nonsense variant (c.4420A>T) in MED13L was detected in a further subject in the course of routine whole-exome sequencing. By analyzing the clinical data of our patients along with those recently described in the literature, we confirm that there is a common, recognizable phenotype associated with MED13L haploinsufficiency, which includes intellectual disability and a distinctive facial appearance. Congenital heart diseases are found in some subjects with various degree of severity. Our observation of cleft palate, ataxia, epilepsy and childhood leukemia observed in single cases broadens the known clinical spectrum. Haploinsufficiency for MED13L should be considered in the differential diagnosis of the 1p36 microdeletion syndrome, due to overlapping dysmorphic facial features in some patients. The introduction of massive parallel-sequencing techniques into clinical practice is expected to allow for detection of other causative point variants in MED13L. Analysis of genomic data in connection with deep clinical evaluation of patients could elucidate genetic heterogeneity of the MED13L haploinsufficiency phenotype. 相似文献
30.
R. Barba Asuncion Gonzalvez‐Gasch D. Joya Seijo J. Marco J. Canora S. Plaza M. Angelina García A. Zapatero 《Journal of thrombosis and haemostasis》2018,16(10):2003-2007
Essentials
- Emerging evidence shows that patients with liver disease are not protected from thrombotic events.
- We assessed the risk of venous thromboembolism (VTE) in patients with liver disease.
- The presence of VTE resulted in an increase in mortality for patients with liver disease.
- Hospitalized patients with moderate‐severe liver disease had low risk of VTE during admission.