全文获取类型
收费全文 | 62520篇 |
免费 | 4040篇 |
国内免费 | 288篇 |
专业分类
耳鼻咽喉 | 611篇 |
儿科学 | 1802篇 |
妇产科学 | 1519篇 |
基础医学 | 8504篇 |
口腔科学 | 1434篇 |
临床医学 | 6159篇 |
内科学 | 13072篇 |
皮肤病学 | 1198篇 |
神经病学 | 6382篇 |
特种医学 | 2415篇 |
外国民族医学 | 25篇 |
外科学 | 8146篇 |
综合类 | 316篇 |
一般理论 | 25篇 |
预防医学 | 5289篇 |
眼科学 | 967篇 |
药学 | 4296篇 |
1篇 | |
中国医学 | 139篇 |
肿瘤学 | 4548篇 |
出版年
2023年 | 533篇 |
2022年 | 935篇 |
2021年 | 2048篇 |
2020年 | 1215篇 |
2019年 | 1710篇 |
2018年 | 1990篇 |
2017年 | 1415篇 |
2016年 | 1587篇 |
2015年 | 1851篇 |
2014年 | 2509篇 |
2013年 | 3190篇 |
2012年 | 4702篇 |
2011年 | 4733篇 |
2010年 | 2424篇 |
2009年 | 2292篇 |
2008年 | 3882篇 |
2007年 | 3749篇 |
2006年 | 3480篇 |
2005年 | 3422篇 |
2004年 | 2911篇 |
2003年 | 2664篇 |
2002年 | 2400篇 |
2001年 | 789篇 |
2000年 | 755篇 |
1999年 | 722篇 |
1998年 | 502篇 |
1997年 | 374篇 |
1996年 | 325篇 |
1995年 | 334篇 |
1994年 | 341篇 |
1993年 | 378篇 |
1992年 | 672篇 |
1991年 | 618篇 |
1990年 | 507篇 |
1989年 | 341篇 |
1988年 | 325篇 |
1987年 | 312篇 |
1986年 | 263篇 |
1985年 | 306篇 |
1984年 | 243篇 |
1983年 | 169篇 |
1982年 | 162篇 |
1981年 | 147篇 |
1979年 | 177篇 |
1978年 | 147篇 |
1977年 | 139篇 |
1976年 | 144篇 |
1975年 | 150篇 |
1974年 | 187篇 |
1973年 | 158篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
41.
42.
43.
44.
Marco Maruzzo Umberto Basso Eugenio Borsatti Laura Evangelista Filippo Alongi Orazio Caffo Francesca Maines Sara Galuppo Rocco De Vivo Fable Zustovich Dario Palleschi Andrea Zivi Teodoro Sava Mariella Sorarù Roberto Iacovelli Maurizio Nicodemo Susanne Baier Lucia Fratino Vittorina Zagonel 《Clinical genitourinary cancer》2019,17(1):e187-e194
Background
Radium 223 was introduced for metastatic castration-resistant prostate cancer based on the results of a randomized controlled trial showing risk reduction for death and skeletal events. Our aim was to evaluate the outcome of patients receiving radium 223 in a real-world setting.Patients and Methods
We conducted a multicenter retrospective analysis in the Triveneto region of Italy.Results
One hundred fifty-eight patients received radium 223 in our region. After a median follow-up of 9.5 months, 75 patients died. The median overall survival (OS) was 14.2 months, and the median progression-free survival (PFS) was 6.2 months. Seventy-one (45%) patients achieved progression as best response. Thirty-seven (23%) patients stopped the treatment early because of progression. Eastern Cooperative Oncology Group performance status was prognostic for OS (18.4 vs. 12.3 vs. 7.5 months; 0 vs. 1, P = .0062; 0 vs. 2, P = .0002), whereas previous prostatectomy or docetaxel exposure were not. A neutrophil to lymphocytes ratio ≥ 3 significantly impacted OS (18.1 vs. 9.7 months; P < .001) and slightly impacted PFS (6.6 vs. 5.6 months; P = .05). Patients with a baseline alkaline phosphatase (ALP) value ≥ 220 U/L had worse OS and PFS (24.1 vs. 10.5 months; 7.2 vs. 5.5 months; P < .001). Patients with changes in ALP value achieved better OS (P = .029) and PFS (P = .002). There was no difference according to the line of therapy (0 vs. ≥ 1; P = .490). The main grade 3/4 toxicities were anemia, asthenia, and thrombocytopenia.Conclusion
This large real-world report confirms comparable OS and PFS data when compared with the pivotal study, as well as the predictive role of ALP and neutrophil to lymphocytes ratio. The definition of the optimal position of radium 223 in the treatment of metastatic castration-resistant prostate cancer has still to be defined. 相似文献45.
Darren R. Feldman MD Yasser Ged MBBS Chung-Han Lee PhD Andrea Knezevic MS Ana M. Molina MD Ying-Bei Chen PhD Joshua Chaim DO Devyn T. Coskey MS Samuel Murray MS Satish K. Tickoo MD Victor E. Reuter MD Sujata Patil PhD Han Xiao MD Jahan Aghalar MD Arlyn J. Apollo MD Maria I. Carlo MD Robert J. Motzer MD Martin H. Voss MD 《Cancer》2020,126(24):5247-5255
46.
47.
Oral Everolimus for Treatment of a Giant Left Ventricular Rhabdomyoma in a Neonate—Rapid Tumor Regression Documented by Real Time 3D Echocardiography
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Robert Wagner M.D. Ph.D. Frank Thomas Riede M.D. Hiroshi Seki M.D. Frauke Hornemann M.D. Steffen Syrbe M.D. Ingo Daehnert M.D. Ph.D. Michael Weidenbach M.D. Ph.D. 《Echocardiography (Mount Kisco, N.Y.)》2015,32(12):1876-1879
The presented case reports on successful treatment with everolimus in a neonate with left ventricular giant rhabdomyoma. The authors used a different dosage regime compared to literature and documented rapid tumor regression by 3D echocardiography. 相似文献
48.
Andrea Vliz Ramírez Susanne Krmer Strenger Melissa Solar Lpez Pamela Muoz Cortes Camila Corral Núez 《Special care in dentistry》2019,39(2):225-230
Cerebral palsy (CP) is a condition caused by brain damage before, during, or shortly after birth. Communication can be a challenge when treating patients with CP. Some patients can communicate verbally, while others use augmentative alternative communication tools or have individualized means of communication. Therefore, professional dental treatment in individuals with CP is challenging, especially if the patient is affected by dental trauma and requires emergency treatment. This report shows how individualized communication skills assessment allowed us to successfully manage a 9‐year‐old patient with CP, who suffered extrusive luxation of the permanent lower incisor. In the present case, the teeth were repositioned briefly after the trauma had occurred and then stabilized with a flexible splint according to international guidelines. The teeth remained vital and periodontal repair was observed during the 4‐year follow‐up. 相似文献
49.
C. Knipfer F. Wagner K. Knipfer G. Millesi J. Acero J.A. Hueto E. Nkenke 《International journal of oral and maxillofacial surgery》2019,48(6):841-846
The aim of this study was to evaluate learners’ acceptance of a webinar for continuing medical education that was instigated by the International Association of Oral and Maxillofacial Surgeons (IAOMS). A live, interactive webinar on orthognathic surgery was broadcast via the Internet. The learners’ acceptance of the webinar was evaluated using a standardized, validated questionnaire (Student Evaluation of Educational Quality, SEEQ). One hundred and fifty-three participants attended the webinar; 55 participants (46 male, nine female) completed the questionnaire. The mean age of the respondents was 41.6 ± 10.0 years. The age of male and female respondents did not differ significantly. The respondents were spread over five continents, with the highest number from Brazil. The SEEQ showed a high level of acceptance for almost all subscales. There was no statistically significant difference between male and female respondents concerning acceptance of the webinar (P = 0.614). The wide distribution of participants shows the potential for webinars as facilitators of barrier-free distribution of knowledge. The webinar was well accepted by the attendees independent of sex, specialty, and work experience. However, the sex ratio reflects the underrepresentation of women in oral and maxillofacial surgery. 相似文献
50.