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61.
Combining gemcitabine and capecitabine in patients with advanced biliary cancer: a phase II trial. 总被引:11,自引:0,他引:11
Jennifer J Knox David Hedley Amit Oza Ron Feld Lillian L Siu Eric Chen Mahsan Nematollahi Gregory R Pond Jessica Zhang Malcolm J Moore 《Journal of clinical oncology》2005,23(10):2332-2338
PURPOSE: Biliary cancer has a poor prognosis, and chemotherapy has had little impact. The objectives of this trial were to determine the response rate, time to disease progression, survival, and safety profile of the combination of gemcitabine and capecitabine (GemCap) in patients with advanced biliary cancer. PATIENTS AND METHODS: Eligible patients had pathologically proven, locally advanced or metastatic adenocarcinoma arising from the intra- and extrahepatic bile ducts or gallbladder with no prior chemotherapy. Patients were treated on a 3-week cycle consisting of capecitabine at 650 mg/m(2) orally twice a day for 14 days and gemcitabine at a fixed dose of 1,000 mg/m(2) intravenously over 30 minutes on days 1 and 8. RESULTS: Forty-five patients were enrolled between July 2001 and January 2004. Fifty-three percent of patients had cholangiocarcinoma, 47% had gallbladder cancer, and 89% had metastatic disease. The overall objective response rate was 31%, with an additional 42% of patients with stable disease, for a disease control rate of 73%. The median overall survival time was 14 months (95% CI, 7.3 months to not available), and the median progression-free survival time was 7 months (95% CI, 4.6 to 11.8 months). This chemotherapy combination was generally well tolerated. Transient neutropenia, thrombocytopenia, fatigue, and hand-foot syndrome were commonly observed but were easily managed without discontinuing further treatment. CONCLUSION: The significant antitumor activity combined with a mild toxicity profile seen in this study argue that GemCap chemotherapy may benefit patients with advanced biliary cancer. This regimen warrants further evaluation in a randomized study with survival and quality of life end points. 相似文献
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Acupuncturehasbeenusedforover2000years forawidevarietyofcomplaintswithminimalsideef fects.Clinicallyithasbeenobservedthatpatients havingsimilarailmentsrespondtoacupuncturethera pyinvaryingdegrees.Tofindoutthebasisofsuch variationofefficacyofacupuncturetherapy,surveyof patientswithABObloodgroupswastakenup.Inhu manbeingthechromosome9isaverypopulargene(ABOgene)thatdeterminesourbloodgroups.Link ofbloodgroupswithsomediseasesisknown,e.g.carcinomaofstomachismostfrequentlyseeninpeo plewithgroupA[1]… 相似文献
63.
Mobin M Siddique Chowbay Balram Lucja Fiszer-Maliszewska Amit Aggarwal Angie Tan Patrick Tan Khee C Soo Kanaga Sabapathy 《Cancer epidemiology, biomarkers & prevention》2005,14(9):2245-2252
Polymorphism at codon 72 of p53 results in either the arginine or proline form of p53, whose functional significance in carcinogenesis is controversial. We have investigated if the expression of these p53 polymorphs is selectively regulated, using mRNA from peripheral blood of healthy Asian (Chinese) and the Caucasian (Polish) arginine/proline (arg/pro) heterozygote subjects. Asians were found to preferentially express the pro allele whereas the Caucasians preferentially express the arg allele. On the contrary, about 75% of the heterozygote Chinese breast cancer patients preferentially expressed the arg allele, which rarely contained any somatic mutations. Moreover, histologically normal tissues from Chinese heterozygote breast cancer patients showed selective expression of the arg allele, in contrast to the preferential expression of the pro allele in heterozygote healthy normal breast tissues. Together, the data suggest that the expression of the different p53 polymorphs is selectively regulated in different ethnic populations, and that the arg allele is activated during cancer development in Asians. Thus, the expression status of the p53 polymorphs, rather than the genotypic status, might be a useful indicator for cancer susceptibility. 相似文献
64.
Roy Kakali Satapathy Amit Kumar Houhton Jayne A. L. Flanagan Sarah E. Radha Venkatesan Mohan Viswanathan Sharma Rajni Jain Vandana 《Indian journal of pediatrics》2019,86(11):1051-1053
Indian Journal of Pediatrics - Congenital hyperinsulinism (CHI) is a clinically and genetically heterogeneous disorder, characterized by dysregulated insulin secretion. Pathogenic variants in at... 相似文献
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Ambak Kumar Rai Chandreshwar Prasad Thakur Prabin Kumar Sheetal Saini Amit Kumar Kureel Smita Kumari 《Immunological investigations》2018,47(2):125-134
Background: Natural Killer (NK) cell plays an important role in the innate immune system and is known to produce IFN-γ at an early stage of infection that is essential to eliminate intracellular infection like Leishmania spp. It is already established that Leishmania parasite inhibits the activity of NK cells, avoiding the encounter with the early innate immune response. This, in turn, favors establishment and further dissemination of the infection. Methods: In the present study, we have tried to measure the frequency of different phenotypic subsets of NK cells among visceral leishmaniasis (VL) patients. Results: We have phenotyped three distinct three distinct subsets (CD56–CD161+, CD56+CD161–, and CD56+CD161+) of NK (CD3–) cell using their specific markers CD161 and CD56. Conclusion: Interestingly, we observed selective loss of CD56+CD161+ subset of circulating NK (CD3–) cells. Importantly, the other subsets (i.e., CD56?CD161+ and CD56+CD161–) of circulating NK cells remain unaffected as compared with healthy subjects. 相似文献
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