全文获取类型
收费全文 | 29295篇 |
免费 | 2412篇 |
国内免费 | 33篇 |
专业分类
耳鼻咽喉 | 347篇 |
儿科学 | 1052篇 |
妇产科学 | 714篇 |
基础医学 | 3544篇 |
口腔科学 | 581篇 |
临床医学 | 3715篇 |
内科学 | 5406篇 |
皮肤病学 | 480篇 |
神经病学 | 2832篇 |
特种医学 | 1022篇 |
外科学 | 3699篇 |
综合类 | 665篇 |
一般理论 | 46篇 |
预防医学 | 3248篇 |
眼科学 | 515篇 |
药学 | 2223篇 |
2篇 | |
中国医学 | 51篇 |
肿瘤学 | 1598篇 |
出版年
2022年 | 227篇 |
2021年 | 465篇 |
2020年 | 281篇 |
2019年 | 419篇 |
2018年 | 482篇 |
2017年 | 341篇 |
2016年 | 402篇 |
2015年 | 448篇 |
2014年 | 649篇 |
2013年 | 984篇 |
2012年 | 1254篇 |
2011年 | 1400篇 |
2010年 | 775篇 |
2009年 | 577篇 |
2008年 | 1194篇 |
2007年 | 1318篇 |
2006年 | 1309篇 |
2005年 | 1217篇 |
2004年 | 1212篇 |
2003年 | 1053篇 |
2002年 | 991篇 |
2001年 | 966篇 |
2000年 | 976篇 |
1999年 | 776篇 |
1998年 | 277篇 |
1997年 | 264篇 |
1996年 | 227篇 |
1995年 | 234篇 |
1992年 | 688篇 |
1991年 | 705篇 |
1990年 | 656篇 |
1989年 | 602篇 |
1988年 | 593篇 |
1987年 | 551篇 |
1986年 | 561篇 |
1985年 | 540篇 |
1984年 | 424篇 |
1983年 | 417篇 |
1982年 | 271篇 |
1981年 | 250篇 |
1980年 | 229篇 |
1979年 | 425篇 |
1978年 | 308篇 |
1977年 | 265篇 |
1976年 | 240篇 |
1975年 | 229篇 |
1974年 | 299篇 |
1973年 | 261篇 |
1972年 | 234篇 |
1971年 | 227篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
991.
992.
993.
Devon L. Golem Jennifer T. Martin-Biggers Mallory M. Koenings Katherine Finn Davis Carol Byrd-Bredbenner 《Advances in nutrition (Bethesda, Md.)》2014,5(6):742-759
Sleep is an essential lifestyle factor that contributes to overall health. The inverse relation between sleep duration and weight status has revealed the importance of sleep in nutritional health. This integrative review builds foundational knowledge with regard to sleep vis-à-vis nutrition by summarizing the importance and process of sleep, current sleep recommendations and trends, as well as lifestyle contributors to poor sleep. Additionally, it details the association between sleep and obesity and potential mechanisms for this association. Furthermore, guidance is offered regarding the incorporation of sleep considerations in nutrition counseling, communication, and research. Like many other lifestyle factors that contribute to nutritional health, sleep needs to be considered when examining weight management and health promotion. 相似文献
994.
995.
Srinivas Ganta Amit Singh Niravkumar R. Patel Joseph Cacaccio Yashesh H. Rawal Barbara J. Davis Mansoor M. Amiji Timothy P. Coleman 《Pharmaceutical research》2014,31(9):2490-2502
Purpose
Platinum-based chemotherapy is the treatment of choice for malignant epithelial ovarian cancers, but generalized toxicity and platinum resistance limits its use. Theranostic nanoemulsion with a novel platinum prodrug, myrisplatin, and the pro-apoptotic agent, C6-ceramide, were designed to overcome these limitations.Methods
The nanoemulsions, including ones with an EGFR binding peptide and gadolinium, were made using generally regarded as safe grade excipients and a high shear microfluidization process. Efficacy was evaluated in ovarian cancer cells, SKOV3, A2780 and A2780CP.Results
The nanoemulsion with particle size <150 nm were stable in plasma and parenteral fluids for 24 h. Ovarian cancer cells in vitro efficiently took up the non-targeted and EGFR-targeted nanoemulsions; improved cytotoxicity was observed for the these nanoemulsions with the latter showing a 50-fold drop in the IC50 in SKOV3 cells as compared to cisplatin alone. The addition of gadolinium did not affect cell viability in vitro, but showed relaxation times comparable to Magnevist®.Conclusion
The myrisplatin/C6-ceramide nanoemulsion synergistically enhanced in vitro cytotoxicity. An EGFR binding peptide addition further increased in vitro cytotoxicity in EGFR positive cancer cells. The diagnostic version showed MR imaging similar to the clinically relevant Magnevist® and may be suitable as a theranostic for ovarian cancer. 相似文献996.
997.
Amira Ezzat Khamis Amine Mohamed Omar Mohamed Helal Wafaa Mohamed Kamel Bakr 《GMS Krankenhaushygiene interdisziplin?r》2014,9(2)
Aim: Catheter associated urinary tract infections (CAUTI) are the most common hospital-acquired infection in ICUs. The aim of this study was to estimate the effectiveness of an intervention program by implementing urinary catheter bundle elements to reduce the CAUTI frequency in an ICU. Methods: The intervention study was conducted over a period of 6 months. During a pre-intervention phase, the base line catheter associated CAUTI incidence rates were determined and compared with the incidence rates during the post-intervention phase. The compliance of health care staff with urinary catheter bundle elements was also measured. The implemented CAUTI prevention bundle consisted of hand hygiene, wearing personal protective equipment, use of disposable gloves, cleansing of urethral meatus prior to catheter insertion using sterile saline, assessment of catheter need, aseptic urine sampling technique, and correct draining bag positioning.Results: During the study period, 55 out of 77 patients were diagnosed with a CAUTI. The mean CAUTI incidence rate for the pre-intervention period was 90.12/1,000 catheter days and for the post intervention phase 65.69/1,000 catheter days. The CAUTIs rate was inversely proportional to insertion bundle elements and maintenance bundle elements compliance rate. This negative relationship was statistically significant only with maintenance bundle elements (p=0.042) (rs=–0.828). The compliance rate of the ICU nurses to the bundle elements was raised to 100% during the last 2 months of the post intervention phase.Conclusion: Increased compliance to recommended catheter associated urinary tract infections preventive practices reduced the incidence of CAUTI in an ICU unit. It is simple and effective and is recommended as a part of patient safety culture. 相似文献
998.
James M. Davis Alison R. Manley Simon B. Goldberg Stevens S. Smith Douglas E. Jorenby 《Journal of substance abuse treatment》2014
Smoking continues to take an enormous toll on society, and although most smokers would like to quit, most are unsuccessful using existing therapies. These findings call on researchers to develop and test therapies that provide higher rates of long-term smoking abstinence. We report results of a randomized controlled trial comparing a novel smoking cessation treatment using mindfulness training to a matched control based on the American Lung Association's Freedom From Smoking program. Data were collected on 175 low socioeconomic status smokers in 2011–2012 in a medium sized midwestern city. A significant difference was not found in the primary outcome; intent-to-treat biochemically confirmed 6-month smoking abstinence rates were mindfulness = 25.0%, control = 17.9% (p = 0.35). Differences favoring the mindfulness condition were found on measures of urges and changes in mindfulness, perceived stress, and experiential avoidance. While no significant differences were found in quit rates, the mindfulness intervention resulted in positive outcomes. 相似文献
999.