全文获取类型
收费全文 | 3807篇 |
免费 | 217篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 25篇 |
儿科学 | 101篇 |
妇产科学 | 60篇 |
基础医学 | 456篇 |
口腔科学 | 187篇 |
临床医学 | 299篇 |
内科学 | 940篇 |
皮肤病学 | 52篇 |
神经病学 | 349篇 |
特种医学 | 68篇 |
外科学 | 534篇 |
综合类 | 36篇 |
一般理论 | 1篇 |
预防医学 | 302篇 |
眼科学 | 46篇 |
药学 | 204篇 |
中国医学 | 17篇 |
肿瘤学 | 363篇 |
出版年
2024年 | 2篇 |
2023年 | 15篇 |
2022年 | 43篇 |
2021年 | 106篇 |
2020年 | 72篇 |
2019年 | 131篇 |
2018年 | 131篇 |
2017年 | 68篇 |
2016年 | 61篇 |
2015年 | 99篇 |
2014年 | 136篇 |
2013年 | 160篇 |
2012年 | 309篇 |
2011年 | 312篇 |
2010年 | 157篇 |
2009年 | 152篇 |
2008年 | 284篇 |
2007年 | 274篇 |
2006年 | 291篇 |
2005年 | 276篇 |
2004年 | 238篇 |
2003年 | 189篇 |
2002年 | 187篇 |
2001年 | 17篇 |
2000年 | 26篇 |
1999年 | 29篇 |
1998年 | 28篇 |
1997年 | 24篇 |
1996年 | 21篇 |
1995年 | 29篇 |
1994年 | 18篇 |
1993年 | 21篇 |
1992年 | 18篇 |
1991年 | 10篇 |
1990年 | 8篇 |
1989年 | 7篇 |
1988年 | 5篇 |
1987年 | 5篇 |
1986年 | 6篇 |
1985年 | 4篇 |
1984年 | 7篇 |
1983年 | 11篇 |
1982年 | 5篇 |
1981年 | 13篇 |
1980年 | 7篇 |
1975年 | 2篇 |
1973年 | 5篇 |
1972年 | 2篇 |
1971年 | 3篇 |
1970年 | 2篇 |
排序方式: 共有4040条查询结果,搜索用时 31 毫秒
991.
992.
993.
994.
N Floc'h CW Kinkade T Kobayashi A Aytes C Lefebvre A Mitrofanova RD Cardiff A Califano MM Shen C Abate-Shen 《Cancer research》2012,72(17):4483-4493
Although the prognosis for clinically localized prostate cancer is now favorable, there are still no curative treatments for castration-resistant prostate cancer (CRPC) and, therefore, it remains fatal. In this study, we investigate a new therapeutic approach for treatment of CRPC, which involves dual targeting of a major signaling pathway that is frequently deregulated in the disease. We found that dual targeting of the Akt and mTOR signaling pathways with their respective inhibitors, MK-2206 and ridaforolimus (MK-8669), is highly effective for inhibiting CRPC in preclinical studies in vivo using a refined genetically engineered mouse model of the disease. The efficacy of the combination treatment contrasts with their limited efficacy as single agents, since delivery of MK-2206 or MK-8669 individually had a modest impact in vivo on the overall tumor phenotype. In human prostate cancer cell lines, although not in the mouse model, the synergistic actions of MK-2206 and ridaforolimus (MK-8669) are due in part to limiting the mTORC2 feedback activation of Akt. Moreover, the effects of these drugs are mediated by inhibition of cellular proliferation via the retinoblastoma (Rb) pathway. Our findings suggest that dual targeting of the Akt and mTOR signaling pathways using MK-2206 and ridaforolimus (MK-8669) may be effective for treatment of CRPC, particularly for patients with deregulated Rb pathway activity. Cancer Res; 72(17); 4483-93. ?2012 AACR. 相似文献
995.
Kensler TW Ng D Carmella SG Chen M Jacobson LP Muñoz A Egner PA Chen JG Qian GS Chen TY Fahey JW Talalay P Groopman JD Yuan JM Hecht SS 《Carcinogenesis》2012,33(1):101-107
Epidemiological evidence has suggested that consumption of a diet rich in cruciferous vegetables reduces the risk of several types of cancers and chronic degenerative diseases. In particular, broccoli sprouts are a convenient and rich source of the glucosinolate, glucoraphanin, which can release the chemopreventive agent, sulforaphane, an inducer of glutathione S-transferases. Two broccoli sprout-derived beverages, one sulforaphane-rich (SFR) and the other glucoraphanin-rich (GRR), were evaluated for pharmacodynamic action in a crossover clinical trial design. Study participants were recruited from the farming community of He Zuo Township, Qidong, China, previously documented to have a high incidence of hepatocellular carcinoma with concomitant exposures to aflatoxin and more recently characterized with exposures to substantive levels of airborne pollutants. Fifty healthy participants were randomized into two treatment arms. The study protocol was as follows: a 5 days run-in period, a 7 days administration of beverage, a 5 days washout period and a 7 days administration of the opposite beverage. Urinary excretion of the mercapturic acids of acrolein, crotonaldehyde, ethylene oxide and benzene were measured both pre- and postinterventions using liquid chromatography tandem mass spectrometry. Statistically significant increases of 20-50% in the levels of excretion of glutathione-derived conjugates of acrolein, crotonaldehyde and benzene were seen in individuals receiving SFR, GRR or both compared with their preintervention baseline values. No significant differences were seen between the effects of SFR versus GRR. Intervention with broccoli sprouts may enhance detoxication of airborne pollutants and attenuate their associated health risks. 相似文献
996.
997.
998.
Nuria Galofré Alvaro 《Seminarios de la Fundación Espa?ola de Reumatología》2009,10(4):118-123
Osteoporosis is one of the systemic effects associated with chronic obstructive pulmonary disease (COPD). Risk factors for bone loss include smoking, skeletal muscle weakness, low bone mass index (BMI), vitamin D deficiency, glucocorticoid use, hypogonadism and systemic inflammation. The most important clinical feature is vertebral fracture, due to its significant morbidity and mortality. The treatment of osteoporosis includes calcium and vitamin D, bisphosphonates, anabolic agents and pulmonary rehabilitation. Prospective studies are required to determine the prevalence of osteoporosis in COPD and to identify which patients are at high risk for osteoporotic fracture. The development of new drugs to control systemic inflammation may contribute to specific treatments for osteoporosis in COPD. 相似文献
999.
1000.