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11.
Charanpreet Singh Nishant Jindal Padma Youron Pankaj Malhotra Gaurav Prakash Alka Khadwal Arihant Jain Sreejesh Sreedharanunni Man Updesh Singh Sachdeva Shano Naseem Neelam Varma Subhash Varma Deepesh P. Lad 《Indian journal of hematology & blood transfusion》2021,37(2):313
To report the efficacy, safety, and quality of life (QoL) on generic and innovator ibrutinib in Indian CLL patients. This was a single centre, prospective study of treatment-naive (TN), and relapsed/refractory (R/R) CLL patients receiving ibrutinib in India. The choice of innovator or generic ibrutinib was as per patient discretion. Response and adverse events were recorded as per the 2018 iwCLL guidelines and CTCAEv4.0. QoL was assessed using the EORTC QLQ-C30 and CLL17 questionnaires. A total of 32 CLL patients (TN, n = 7 and R/R, n = 25) received ibrutinib from 2016–2019. The median age was 60 years (37–84). All TN patients attained partial response without any grade 3/4 adverse events (AE). Ibrutinib was less tolerated in the R/R setting, with 52% patients developing grade 3/4 AE and required dose reduction. Eleven patients (44%) died during follow-up. Grade 3–5 infections were seen in 44% of R/R CLL patients. Generic ibrutinib (n = 8) was comparable to innovator ibrutinib (n = 17) in terms of efficacy, safety, and QoL. Ibrutinib is less well tolerated in Indian R/R CLL patients. Infections are a common cause of morbidity and mortality. This study affirms the safety and efficacy of generic ibrutinib.Electronic supplementary materialThe online version of this article (10.1007/s12288-020-01378-6) contains supplementary material, which is available to authorized users. 相似文献
12.
Alka Kumari Nasreen Bano Doongar R. Chaudhary Bhavanath Jha 《Journal of basic microbiology》2021,61(1):37-44
The endemic spread of plastic in the environment requires urgent need of a sustainable approach. Marine microbes found to have vast bioactivity and play a central role in biogeochemical cycling in the ocean; however, very few of them had been explored for biochemical cycling or plastic degradation. In the present study, we report the draft genome sequence of marine Bacillus sp. AIIW2 which was found to utilize plastic as a carbon source. The Bacillus sonorensis SRCM101395 was used as a reference genome for mapping the reads. The genome size of strain AIIW2 was approximately 4.4 Mb and composed of 4737 coding sequences with 45.7% G + C contents. The whole genome comparison of strain AIIW2 with three closest Bacillus strains showed strain specificity, the 16S ribosomal RNA sequence shows 99.93% similarity with Bacillus paralicheniformis KJ-16T (KY694465). This genome data would provide the genetic basis in developing plastic bioremediation approaches and discover the enzymes pertinent in the biodegradation processes. 相似文献
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The Journal of Obstetrics and Gynecology of India - The aim of this study was to compare the efficacy and safety of sublingual and vaginal misoprostol in second-trimester termination of pregnancy... 相似文献
14.
Rare coexistence of invasive papillary carcinoma with infiltrating ductal carcinoma in male breast: report of a case 总被引:1,自引:0,他引:1
Invasive papillary breast carcinoma is a subtype of breast cancer that is more frequent in males. An intraductal carcinoma can coexist with it but association of an infiltrating carcinoma has not been described. This report presents a rare case of a 35-year-old man with dual malignancy in the same breast. The patient had two separate nodules, one with the morphology of invasive papillary carcinoma and the other having features of an infiltrating ductal carcinoma. To the best of our knowledge this is the first case report describing the coexistence of these two entities. 相似文献
15.
AV Gosavi PS Murarkar DN Lanjewar RV Ravikar 《Indian journal of hematology & blood transfusion》2011,27(3):172-176
Transient leukemia (TL) also referred to as transient abnormal myelopoiesis (TAM) or transient myeloproliferative disorder
(TMD) is a unique syndrome that frequently occurs in newborns with Down syndrome (DS). It manifests in the first few days
of life and shows leukocytosis with blast cells in the blood and bone marrow. This leukemia resolves spontaneously within
first few months of life in the majority of cases. In this report we describe two newborns with a karyotype of 47,XY,+21,
presented with marked leukocytosis and many blast cells in the peripheral blood. In both the cases, the blasts disappeared
and the total leukocyte count reverted to normal without any specific treatment. 相似文献
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Ashok Kumar Reddy Raja Rami Reddy Muralidhar Rao Paruvelli Srinivas Ambatipudi Alka Rani Sikander A. K. Lodhi Juturi Maruthi Lokabhi Reddy K. Ramakanth Reddy Niraj Pandey Rituraj Videkar Manish Kumar Sinha Ajit Babu Majji Nilanjana Deb-Jorder Atul Kumar Sahu Jyostna Myneni Anina Abraham 《International ophthalmology》2015,35(1):37-42
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