全文获取类型
收费全文 | 47612篇 |
免费 | 4708篇 |
国内免费 | 95篇 |
专业分类
耳鼻咽喉 | 293篇 |
儿科学 | 1489篇 |
妇产科学 | 1279篇 |
基础医学 | 6813篇 |
口腔科学 | 949篇 |
临床医学 | 5437篇 |
内科学 | 9241篇 |
皮肤病学 | 825篇 |
神经病学 | 4529篇 |
特种医学 | 1748篇 |
外国民族医学 | 3篇 |
外科学 | 5722篇 |
综合类 | 861篇 |
现状与发展 | 1篇 |
一般理论 | 52篇 |
预防医学 | 5527篇 |
眼科学 | 1087篇 |
药学 | 3376篇 |
中国医学 | 84篇 |
肿瘤学 | 3099篇 |
出版年
2023年 | 408篇 |
2022年 | 680篇 |
2021年 | 1365篇 |
2020年 | 751篇 |
2019年 | 1176篇 |
2018年 | 1221篇 |
2017年 | 906篇 |
2016年 | 989篇 |
2015年 | 1010篇 |
2014年 | 1391篇 |
2013年 | 1871篇 |
2012年 | 2748篇 |
2011年 | 2774篇 |
2010年 | 1554篇 |
2009年 | 1346篇 |
2008年 | 2201篇 |
2007年 | 2351篇 |
2006年 | 2252篇 |
2005年 | 2142篇 |
2004年 | 2049篇 |
2003年 | 1894篇 |
2002年 | 1754篇 |
2001年 | 1233篇 |
2000年 | 1233篇 |
1999年 | 1080篇 |
1998年 | 480篇 |
1997年 | 428篇 |
1996年 | 386篇 |
1995年 | 324篇 |
1994年 | 352篇 |
1993年 | 336篇 |
1992年 | 817篇 |
1991年 | 785篇 |
1990年 | 771篇 |
1989年 | 670篇 |
1988年 | 694篇 |
1987年 | 649篇 |
1986年 | 601篇 |
1985年 | 661篇 |
1984年 | 538篇 |
1983年 | 425篇 |
1982年 | 265篇 |
1981年 | 286篇 |
1979年 | 467篇 |
1978年 | 345篇 |
1977年 | 258篇 |
1976年 | 271篇 |
1974年 | 285篇 |
1973年 | 261篇 |
1972年 | 269篇 |
排序方式: 共有10000条查询结果,搜索用时 31 毫秒
991.
Young Sexual Minority Males in the United States: Sociodemographic Characteristics And Sexual Attraction,Identity and Behavior
下载免费PDF全文
![点击此处可从《Perspectives on sexual and reproductive health》网站下载免费的PDF全文](/ch/ext_images/free.gif)
992.
993.
994.
Rune Wilkens Alexandra Wilson Peter N. Burns Subrata Ghosh Stephanie R. Wilson 《Ultrasound in medicine & biology》2018,44(11):2189-2198
A small population of patients with severe Crohn's disease (CD) exhibit atypical lack of intensity decline on intestinal contrast-enhanced ultrasound. From a retrospective CD cohort examined with contrast-enhanced ultrasound, 104 patients were identified. Twenty study patients with severe active disease exhibited high peak enhancement (>23 dB) and minimal decline. From the same cohort, 84 control patients also exhibited high peak enhancement >23dB, but with typical intensity decline. Patient outcomes were assessed. Time–intensity curve analysis revealed a significantly higher (p < 0.0001) area under the curve (44.7 ± 1.5 dB·s), washout time and intensities at 60s and 120s in the study population compared with controls (40.0 ± 1.1 dB·s). Study patients had a worse overall outcome with surgery in 30% versus 10% (p?=?0.027) during follow-up. Heightened enhancement with lack of decline on contrast-enhanced ultrasound suggests microbubbles are stuck within the inflamed bowel wall for an extended period. This observation occurs in patients with severe disease and a bad outcome. 相似文献
995.
996.
Factors that affect implementation of a nurse staffing directive: results from a qualitative multi‐case evaluation
下载免费PDF全文
![点击此处可从《Journal of advanced nursing》网站下载免费的PDF全文](/ch/ext_images/free.gif)
997.
998.
Alexandra Vétillard Barbara Jonchère Marie Moreau Bertrand Toutain Cécile Henry Simon Fontanel Anne-Charlotte Bernard Mario Campone Catherine Guette Olivier Coqueret 《Oncotarget》2015,6(41):43342-43362
Activated in response to chemotherapy, senescence is a tumor suppressive mechanism that induces a permanent loss of proliferation. However, in response to treatment, it is not really known how cells can escape senescence and how irreversible or incomplete this pathway is. We have recently described that cells that escape senescence are more transformed than non-treated parental cells, they resist anoikis and rely on Mcl-1. In this study, we further characterize this emergence in response to irinotecan, a first line treatment used in colorectal cancer. Our results indicate that Akt was activated as a feedback pathway during the early step of senescence. The inhibition of the kinase prevented cell emergence and improved treatment efficacy, both in vitro and in vivo. This improvement was correlated with senescence inhibition, p21waf1 downregulation and a concomitant activation of apoptosis due to Noxa upregulation and Mcl-1 inactivation. The inactivation of Noxa prevented apoptosis and increased the number of emergent cells. Using either RNA interference or p21waf1-deficient cells, we further confirmed that an intact p53-p21-senescence pathway favored cell emergence and that its downregulation improved treatment efficacy through apoptosis induction. Therefore, although senescence is an efficient suppressive mechanism, it also generates more aggressive cells as a consequence of apoptosis inhibition. We therefore propose that senescence-inducing therapies should be used sequentially with drugs favoring cell death such as Akt inhibitors. This should reduce cell emergence and tumor relapse through a combined induction of senescence and apoptosis. 相似文献
999.
1000.
Jamilah Taylor Emily Namey Annette Carrington Johnson Greg Guest 《Journal of health communication》2017,22(6):532-544
Public health researchers are charged with communicating study findings to appropriate audiences. Dissemination activities typically target the academic research community. However, as participatory research grows, researchers are increasingly exploring innovative dissemination techniques to reach broader audiences, particularly research participants and their communities. One technique is ethnodrama/ethnotheatre, a written or live performance based on study findings. Though used effectively in social change programs, dramas are seldom used to distribute research findings exclusively. Therefore, little information is available about planning and implementing an ethnodrama for this purpose. We present a case study describing the process of planning and implementing an ethnodrama in the context of the Durham Focus Group Study, which explored men’s health-seeking behaviors and experiences with health and healthcare services in Durham, North Carolina. Here, we highlight lessons learned throughout the production of the ethnodrama, and how we addressed challenges associated with transforming research data into educational entertainment. Additionally, we provide discussion of audience feedback, which indicated that our ethnodrama evoked an urgency to change health behaviors among lay persons (67%) and delivery of health services among those identifying as providers (84%), pointing to the success of the performance in both entertaining and educating the audience. 相似文献