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11.
Clinical Benefit in Response to Palbociclib Treatment in Refractory Uterine Leiomyosarcomas with a Common CDKN2A Alteration 下载免费PDF全文
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Fruehauf JH Back W Eiermann A Lang MC Pessel M Marlinghaus E Melchert F Volz-Köster S Volz J 《Archives of gynecology and obstetrics》2008,277(2):143-150
Background High intensity focused ultrasound (HIFU) is a novel method which offers the non-invasive ablation of tissues without harming
overlying organs or skin. It has been introduced successfully in urology for the ablation of prostatic hyperplasia and seems
to be promising in the treatment of uterine fibroids. In this study we aimed to examine the feasibility and possible side
effects of HIFU treatment of uterine tissues using an experimental mobile HIFU unit with ultrasound guidance.
Methods For these experiments, a 1.07 MHz ultrasound source was used which allows treatment depths between 0 and 10 cm. In 12 patients
scheduled to have abdominal hysterectomy, 5–60 impulses of HIFU were applied through the intact skin upon uterine tissues
directly prior to the surgical procedure. Tissue intensities lay between 3,200 and 6,300 W/cm2 and a fixed pulse length of
4 s was used.
Results No side effects were encountered other than one first-degree skin burn and the treatment was well tolerated. Histology showed
clearly demarcated coagulative necrosis in the targeted tissues. Treatment was concluded in less than 45 min for each patient.
Conclusion Focused ultrasound is an effective method to selectively destroy tissue within the uterus and the transabdominal access route
is very feasible. This study shows that a mobile ultrasound source can be used safely and effectively to destroy uterine tissues,
such as fibroids, without major side effects. 相似文献
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Identifying personality traits and neural signatures that predict placebo responsiveness is important, both on theoretical and practical grounds. In the present functional magnetic resonance imaging (fMRI) study, we performed multiple-regression interaction analysis to investigate whether hypnotic susceptibility (HS), a cognitive trait referring to the responsiveness to suggestions, explains interindividual differences in the neural mechanisms related to conditioned placebo analgesia in healthy volunteers. HS was not related to the overall strength of placebo analgesia. However, we found several HS-related differences in the patterns of fMRI activity and seed-based functional connectivity that accompanied placebo analgesia. Specifically, in subjects with higher HS, the placebo response was related to increased anticipatory activity in a right dorsolateral prefrontal cortex focus, and to reduced functional connectivity of that focus with brain regions related to emotional and evaluative pain processing (anterior mid-cingulate cortex/medial prefrontal cortex); an opposite pattern of fMRI activity and functional connectivity was found in subjects with lower HS. During pain perception, activity in the regions reflecting attention/arousal (bilateral anterior thalamus/left caudate) and self-related processing (left precuneus and bilateral posterior temporal foci) was negatively related to the strength of the analgesic placebo response in subjects with higher HS, but not in subjects with lower HS. These findings highlight HS influences on brain circuits related to the placebo analgesic effects. More generally, they demonstrate that different neural mechanisms can be involved in placebo responsiveness, depending on individual cognitive traits. 相似文献
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Au R Seshadri S Wolf PA Elias M Elias P Sullivan L Beiser A D'Agostino RB 《Experimental aging research》2004,30(4):333-358
A previous publication presented normative data on neuropsychological tests stratified by age, gender, and education based on the Original Cohort of the Framingham Heart Study. Many contemporary investigations include subject samples with higher levels of education, a factor known to affect cognitive performance. Secular change in education prompted the reexamination of norms in the children of the Original Cohort. The study population consisted of 853 men and 988 women from the Offspring Study, free of clinical neurological disease, who underwent a neuropsychological examination, which included tests given to their parents in 1974 to 1976 as well as additional newer tests to provide a more comprehensive battery. The Offspring population overall was more evenly distributed by gender and better educated. Their performance on cognitive tests was superior to that of the Original Cohort. Multivariable analyses revealed that more years of education explained only a part of the cohort differences. These findings suggest that continued surveillance of each generation is necessary to document the impact that unique social and economic variables have on cognitive function. Here, the authors provide updated normative data. 相似文献
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Ciurtin Coziana Robinson George A. Pineda-Torra Ines Jury Elizabeth C. 《Clinical rheumatology》2022,41(4):961-964
Clinical Rheumatology - 相似文献
18.
A phase I trial and viral clearance study of reovirus (Reolysin) in children with relapsed or refractory extra‐cranial solid tumors: A Children's Oncology Group Phase I Consortium report 下载免费PDF全文
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Lyons Naomi Strasser Alexa Beitz Bernard Teismann Tobias Ostermann Thomas Anderle Laura Michalak Johannes 《Cognitive therapy and research》2021,45(3):508-516
Cognitive Therapy and Research - Emotions play a central role in mental disorder and especially in depression. They are sensed in the body, and it has recently been shown in healthy participants... 相似文献