全文获取类型
收费全文 | 2476篇 |
免费 | 155篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 42篇 |
妇产科学 | 34篇 |
基础医学 | 268篇 |
口腔科学 | 50篇 |
临床医学 | 171篇 |
内科学 | 603篇 |
皮肤病学 | 25篇 |
神经病学 | 242篇 |
特种医学 | 121篇 |
外科学 | 330篇 |
综合类 | 3篇 |
预防医学 | 241篇 |
眼科学 | 65篇 |
药学 | 166篇 |
中国医学 | 8篇 |
肿瘤学 | 273篇 |
出版年
2024年 | 6篇 |
2023年 | 41篇 |
2022年 | 100篇 |
2021年 | 174篇 |
2020年 | 89篇 |
2019年 | 113篇 |
2018年 | 107篇 |
2017年 | 89篇 |
2016年 | 88篇 |
2015年 | 120篇 |
2014年 | 110篇 |
2013年 | 141篇 |
2012年 | 196篇 |
2011年 | 177篇 |
2010年 | 105篇 |
2009年 | 100篇 |
2008年 | 131篇 |
2007年 | 134篇 |
2006年 | 117篇 |
2005年 | 89篇 |
2004年 | 103篇 |
2003年 | 60篇 |
2002年 | 54篇 |
2001年 | 21篇 |
2000年 | 21篇 |
1999年 | 21篇 |
1998年 | 16篇 |
1997年 | 4篇 |
1996年 | 9篇 |
1995年 | 7篇 |
1994年 | 2篇 |
1993年 | 8篇 |
1992年 | 18篇 |
1991年 | 11篇 |
1990年 | 7篇 |
1989年 | 9篇 |
1988年 | 7篇 |
1987年 | 4篇 |
1986年 | 3篇 |
1985年 | 6篇 |
1984年 | 2篇 |
1983年 | 2篇 |
1977年 | 2篇 |
1976年 | 3篇 |
1973年 | 3篇 |
1972年 | 4篇 |
1971年 | 3篇 |
1970年 | 1篇 |
1969年 | 4篇 |
1968年 | 4篇 |
排序方式: 共有2649条查询结果,搜索用时 0 毫秒
991.
Alessio Vincenzo Mariolo Thibault Vieira Jean-Baptiste Stern Loïc Perrot Raffaele Caliandro Remi Escande Emmanuel Brian Madalina Grigoroiu Guillaume Boddaert Dominique Gossot Agathe Seguin-Givelet 《Journal of thoracic disease》2021,13(7):4371
BackgroundThoracoscopic localization of small peripheral pulmonary nodules is a concern. Failure can lead to larger parenchymal resection or conversion to thoracotomy. This study evaluates our experience in preoperative electromagnetic navigation bronchoscopy-guided localization of small peripheral lung lesions.MethodsFrom January 2017 to March 2020 clinical, radiographic, surgical, and pathological data of patients who underwent electromagnetic navigation bronchoscopy (ENB)-guided methylene blue pleural marking of highly suspected pulmonary lesions before a full thoracoscopic resection were evaluated. Localization was performed for solid or mixed subpleural nodules measuring <10 mm, solid nodules measuring <20 mm located at more than 1 cm from the pleura and any pure ground glass opacity. Successful localization was defined as successful identification and thoracoscopic resection of target lesions.ResultsForty-eight patients were included: 30 solid nodules (63%), 12 pure GGO (25%) and 6 mixed (13%). The median largest diameter at CT-scan was 11 mm (IQR, 9–14 mm) while the median distance from the pleural surface was 12 mm (IQR, 6–16 mm). The median ENB length was 25 min (19–33 min). Localization procedure was successful in 45 cases (94%). No procedural-related complications were reported.ConclusionsENB is a safe and accurate preoperative procedure to localize small lung peripheral lesions. The high successful rate, the absence of related complications, the possibility of performing the procedure in the same operating room with a single general anesthesia, make ENB-guided dye marking an advantageous tool for thoracoscopic pulmonary resection. 相似文献
992.
Stefania Rizzo Giuseppina Calareso Sara Maccagnoni Salvatore Alessio Angileri Fabio Landoni Sara Raimondi Elena Pasquali Roberta Lazzari Massimo Bellomi 《European journal of radiology》2014
Objectives
This study compared the MR measurement of minimum uninvolved cervical stroma and maximum stromal invasion, and the detection of positive lymph nodes with the pathological results. In addition, tumour type and grade were correlated with nodal status and apparent diffusion coefficient (ADC) values.Methods
Patients who underwent surgery and MR at our centre for early stage cervical cancer (FIGO IA1-IIB) were included. Data recorded included: age, date of MR, clinical FIGO (International Federation of Gynacology and Obstetrics) stage, histological type and grade, adjuvant therapy, pre-surgical conisation. MR evaluation included: measurement of the minimum uninvolved stroma, maximum thickness of stromal involvement, presence and site of positive pelvic lymph nodes, calculation of ADC values.Statistical analysis was performed to compare MR and pathological results. The agreement between MR and pathology in measuring depth of stromal invasion was analysed by Bland–Altman plot, calculating the limits of agreement (LoA).Results
113/217 patients underwent adjuvant therapies. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of MR in evaluation of minimum thickness of uninvolved cervical stroma were 88%, 75%, 70%, 90% and 80%; the same values in evaluation of pelvic positive lymph nodes were 64%, 85%, 65%, 84% and 78%. The mean difference between MR and pathological results in measuring maximum depth of stromal invasion was −0.65 mm (95% LoA: −9.37 mm; 8.07 mm). Depth of stromal invasion was strongly related to positive nodal status (p < 0.001). ADC values (available in 51/217 patients) were not associated with the features assessed.Conclusions
Pre-surgical MR is accurate (80%) in evaluating the minimum thickness of uninvolved cervical stroma; MR measurements of maximum depth of stromal invasion differed ±9 mm from the pathological results in 95% of cases. Furthermore, a strong association was found between the depth of stromal invasion and the presence of positive lymph nodes, suggesting that inclusion of these measurements in the MR report might guide the choice of the best treatment option for early cervical cancer patients. 相似文献993.
Ferdinando De Vita Natale Di Martino Alessio Fabozzi Maria Maddalena Laterza Jole Ventriglia Beatrice Savastano Angelica Petrillo Valentina Gambardella Vincenzo Sforza Luigi Marano Annamaria Auricchio Gennaro Galizia Fortunato Ciardiello Michele Orditura 《World journal of gastroenterology : WJG》2014,20(40):14537-14558
Gastric cancer is the fourth most common malignant neoplasm and the second leading cause of death for cancer in Western countries with more than 20000 new cases yearly diagnosed in the United States. Surgery represents the main approach for this disease but, notwithstanding the advances in surgical techniques, we observed a minimal improvement in terms of overall survival with a significant increasing of relapsing disease rates. Despite the development of new drugs has significantly improved the effectiveness of chemotherapy, the prognosis of patients with unresectable or metastatic gastric adenocarcinoma remains poor. Recently, several molecular target agents have been investigated; in particular, trastuzumab represents the first target molecule showing improvements in overall survival in human epithelial growth factor 2-positive gastric cancer patients. New molecules targeting vascular epithelial growth factor, mammalian target of rapamycin, and anti hepatocyte growth factor-c-Met pathway are also under investigation, with interesting results. Anyway, it seems necessary to select more accurately the population to treat with new agents by the identification of new biomarkers in order to optimize the results. In this paper we review the actual “scenario” of targeted treatments, also focusing on the new agents in development for gastric cancer and gastro-esophageal carcinoma, discussing their efficacy and potential applications in clinical practice. 相似文献
994.
995.
Francisco J. Berguido Peter D. Burbelo Alessio Bortolami Francesco Bonfante Kerstin Wernike Donata Hoffmann Anne Balkema-Buschmann Martin Beer William G. Dundon Charles E. Lamien Giovanni Cattoli 《Viruses》2021,13(8)
The recent emergence of SARS-CoV-2 in humans from a yet unidentified animal reservoir and the capacity of the virus to naturally infect pets, farmed animals and potentially wild animals has highlighted the need for serological surveillance tools. In this study, the luciferase immunoprecipitation systems (LIPS), employing the spike (S) and nucleocapsid proteins (N) of SARS-CoV-2, was used to examine the suitability of the assay for antibody detection in different animal species. Sera from SARS-CoV-2 naturally-infected mink (n = 77), SARS-CoV-2 experimentally-infected ferrets, fruit bats and hamsters and a rabbit vaccinated with a purified spike protein were examined for antibodies using the SARS-CoV-2 N and/or S proteins. From comparison with the known neutralization status of the serum samples, statistical analyses including calculation of the Spearman rank-order-correlation coefficient and Cohen’s kappa agreement were used to interpret the antibody results and diagnostic performance. The LIPS immunoassay robustly detected the presence of viral antibodies in naturally infected SARS-CoV-2 mink, experimentally infected ferrets, fruit bats and hamsters as well as in an immunized rabbit. For the SARS-CoV-2-LIPS-S assay, there was a good level of discrimination between the positive and negative samples for each of the five species tested with 100% agreement with the virus neutralization results. In contrast, the SARS-CoV-2-LIPS-N assay did not consistently differentiate between SARS-CoV-2 positive and negative sera. This study demonstrates the suitability of the SARS-CoV-2-LIPS-S assay for the sero-surveillance of SARS-CoV-2 infection in a range of animal species. 相似文献
996.
997.
Evidente A Venturi V Masi M Degrassi G Cimmino A Maddau L Andolfi A 《Journal of natural products》2011,74(12):2520-2525
Sphaeropsidin A, the main phytotoxin produced by Diplodia cupressi, as well as the two natural analogues sphaeropsidins B and C and 14 derivatives obtained by chemical modifications were assayed for antibacterial activity against Xanthomonas oryzae pv. oryzae, Pseudomonas fuscovaginae, and Burkholderia glumae, the causal agents of severe bacterial rice diseases. The results showed a strong and specific activity of sphaeropsidin A against X. oryzae pv. oryzae, while no activity was observed against the other two pathogens. The results of structure-activity relationship studies showed that structural features important to impart this antibacterial activity are the presence of the C-7 carbonyl group and the hemiketalic lactone functionality. The C-13 vinyl group, the double bond of ring C, and/or the tertiary C-9 hydroxy group, as well as the pimarane arrangement of the tricylic carbon skeleton, were also important for the antibacterial activity. These findings may be useful in designing novel compounds for practical applications in agriculture. 相似文献
998.
999.
Alessio G. Morganti Samantha Mignogna Francesco Deodato Mariangela Massaccesi Savino Cilla Franco Calista Giovanni Serafini Cinzia Digesú Gabriella Macchia Vincenzo Picardi Luciana Caravatta Liberato Di Lullo Gianfranco Giglio Giuseppina Sallustio Angelo Piermattei Numa Cellini Vincenzo Valentini 《International journal of radiation oncology, biology, physics》2011